Mei-Tung Chen
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View article: Cyclization of Two Antimicrobial Peptides Improves Their Activity
Cyclization of Two Antimicrobial Peptides Improves Their Activity Open
One promising strategy to combat worldwide antimicrobial resistance involves using cyclic peptides as antibacterial agents. Cyclization of peptides can confer several advantages, including enhanced stability to proteolysis, decreased toxic…
View article: How Unnatural Amino Acids in Antimicrobial Peptides Change Interactions with Lipid Model Membranes
How Unnatural Amino Acids in Antimicrobial Peptides Change Interactions with Lipid Model Membranes Open
This study investigates the potential of antimicrobial peptides (AMPs) as alternatives to combat antibiotic resistance, with a focus on two AMPs containing unnatural amino acids (UAAs), E2-53R (16 AAs) and LE-54R (14 AAs). In both peptides…
View article: Novel Helical Trp‐ and Arg‐Rich Antimicrobial Peptides Locate Near Membrane Surfaces and Rigidify Lipid Model Membranes
Novel Helical Trp‐ and Arg‐Rich Antimicrobial Peptides Locate Near Membrane Surfaces and Rigidify Lipid Model Membranes Open
Antibiotics are losing effectiveness as bacteria become resistant to conventional drugs. To find new alternatives, antimicrobial peptides (AMPs) are rationally designed with different lengths, charges, hydrophobicities ( H ), and hydrophob…