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View article: Camellia japonica Flower Extract and the Active Constituent Hyperoside Repair DNA Damage Through FUNDC1-Mediated Mitophagy Pathway for Skin Anti-Aging
Camellia japonica Flower Extract and the Active Constituent Hyperoside Repair DNA Damage Through FUNDC1-Mediated Mitophagy Pathway for Skin Anti-Aging Open
Skin aging is closely related to mitochondrial dysfunction and cell cycle abnormalities, and developing intervention strategies targeting mitochondrial quality control is an important direction for anti-aging research. In this study, we in…
View article: Effect of Propionate on <scp><i>Citrobacter rodentium</i></scp> Infection in Mice by Regulating <scp>NleH</scp> Expression
Effect of Propionate on <span><i>Citrobacter rodentium</i></span> Infection in Mice by Regulating <span>NleH</span> Expression Open
Propionate is one of the main short chain fatty acids in the gut. Previously, we found that propionate significantly down‐regulated the expression of NleH. NleH is a virulence effector secreted by Citrobacter rodentium ( C. rodentium , C.r…
View article: Uridine-Modified Ruthenium(II) Complex as Lysosomal LIMP-2 Targeting Photodynamic Therapy Photosensitizer for the Treatment of Triple-Negative Breast Cancer
Uridine-Modified Ruthenium(II) Complex as Lysosomal LIMP-2 Targeting Photodynamic Therapy Photosensitizer for the Treatment of Triple-Negative Breast Cancer Open
Lysosome-targeted photodynamic therapy, which enhances reactive oxygen species (ROS)-responsive tumor cell death, has emerged as a promising strategy for cancer treatment. Herein, a uridine (dU)-modified Ru(II) complex (RdU) was synthesize…
View article: Preparation, Characterization, and Antioxidant Activities of Extracts from Amygdalus persica L. Flowers
Preparation, Characterization, and Antioxidant Activities of Extracts from Amygdalus persica L. Flowers Open
A novel water-soluble Amygdalus persica L. flowers polysaccharide (APL) was successfully isolated and purified from Amygdalus persica L. flowers by hot water extraction. Its chemical components and structure were analyzed by IR, GC-MS, and…
View article: Distinguish G4 Dnas by a Ruthenium(Ii) Complex Coordinated with Cinnamenyl Phenanthroline[1,10][4,5 F ] Imidazole
Distinguish G4 Dnas by a Ruthenium(Ii) Complex Coordinated with Cinnamenyl Phenanthroline[1,10][4,5 F ] Imidazole Open
View article: CCDC 1400139: Experimental Crystal Structure Determination
CCDC 1400139: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Ruthenium(II) Complexes Coupled by Erianin Via a Flexible Carbon Chain as a Potential Stabilizer of c-myc G-Quadruplex DNA
Ruthenium(II) Complexes Coupled by Erianin Via a Flexible Carbon Chain as a Potential Stabilizer of c-myc G-Quadruplex DNA Open
Herein, two novel ruthenium(II) complexes coupled by erianin via a flexible carbon chain, [Ru(phen)2(L1-(CH2)4-erianin)](ClO4)2 (L1 = 2-(2-(tri-fluoromethyphenyl))-imidazo [4,5f][1–10]phenanthroline (1) and [Ru(phen)2(L2-(CH2)4-eria)](ClO4…
View article: Inhibitory Effect of <i>β</i>‐Sitosterol on the Ang II‐Induced Proliferation of A7r5 Aortic Smooth Muscle Cells
Inhibitory Effect of <i>β</i>‐Sitosterol on the Ang II‐Induced Proliferation of A7r5 Aortic Smooth Muscle Cells Open
Context . Excessive proliferation of vascular smooth muscle cells (VSMCs) plays a critical role in the development of cardiovascular diseases. β ‐Sitosterol exerts protective effects against the cardiovascular disease. However, whether β ‐…
View article: Novel Chiral Ru(II) Complexes as Potential c-myc G-quadruplex DNA Stabilizers Inducing DNA Damage to Suppress Triple-Negative Breast Cancer Progression
Novel Chiral Ru(II) Complexes as Potential c-myc G-quadruplex DNA Stabilizers Inducing DNA Damage to Suppress Triple-Negative Breast Cancer Progression Open
Currently, effective drugs for triple-negative breast cancer (TNBC) are lacking in clinics. c-myc is one of the core members during TNBC tumorigenesis, and G-rich sequences in the promoter region can form a G-quadruplex conformation, indic…
View article: Stabilization of MYC G-quadruplex DNA by ruthenium (II) complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation
Stabilization of MYC G-quadruplex DNA by ruthenium (II) complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation Open
View article: Fast detection, a precise and sensitive diagnostic agent for breast cancer
Fast detection, a precise and sensitive diagnostic agent for breast cancer Open
View article: Imidazole-based phenanthroline derivatives induce DNA damage-mediated apoptosis to suppress hepatocellular carcinoma
Imidazole-based phenanthroline derivatives induce DNA damage-mediated apoptosis to suppress hepatocellular carcinoma Open
Objective: This study focused on designing and subsequently screening novel phenanthroimidazole derivatives with activity as potential inhibitors of hepatocellular carcinoma. Methods: We synthesized a series of phenanthroimidazole derivati…
View article: Arene Ru(II) Complexes Acted as Potential KRAS G-Quadruplex DNA Stabilizer Induced DNA Damage Mediated Apoptosis to Inhibit Breast Cancer Progress
Arene Ru(II) Complexes Acted as Potential KRAS G-Quadruplex DNA Stabilizer Induced DNA Damage Mediated Apoptosis to Inhibit Breast Cancer Progress Open
A series of arene Ru(II) complexes, [(η6-MeC6H5)Ru(L)Cl]Cl, (L=o-ClPIP, 1; m-ClPIP, 2 and p-ClPIP, 3) (o-ClPIP=2-(2-chlorophenyl)imidazo[4,5-f][1,10]phenanthroline; m-ClPIP=2-(3-chlorophenyl)imidazo[4,5-f][1,10]phenanthroline; p-ClPIP=2-(4…
View article: Arene Ru(II) Complexes with Difluorinated Ligands Act as Potential Inducers of S-Phase Arrest via the Stabilization of c-myc G-Quadruplex DNA
Arene Ru(II) Complexes with Difluorinated Ligands Act as Potential Inducers of S-Phase Arrest via the Stabilization of c-myc G-Quadruplex DNA Open
Here, a series of half-sandwich arene Ru(II) complexes with difluorinated ligands [Ru(η6-arene)(L)Cl] (L1 = 2-(2,3-difluorophenyl)imidazole[4,5f][1,10]-phenanthroline; L2 = 2-(2,4-difluorophenyl)imidazole[4,5f][1,10]-phenanthroline; arene …
View article: Fast detection, a precise and sensitive diagnostic agent for breast cancer
Fast detection, a precise and sensitive diagnostic agent for breast cancer Open
Background Breast cancer targeting diagnostic agent with effective imaging ability is important in guiding plan formulation, prediction, and curative effect evaluation of tumors in clinic. A tumor-targeting nanoprobe based on the functiona…
View article: Synthesis of copper (II) porphyrin complexes and their interaction with c-myc G-quadruplex DNA
Synthesis of copper (II) porphyrin complexes and their interaction with c-myc G-quadruplex DNA Open
Objective: To synthesize copper (II) porphyrin complexes and study their interactions with c-myc G-quadruplex DNA. Methods: The 5-p-hydroxyphenyl-10, 15, 20-tris (p-methoxyphenyl) copper (II) porphyrin complex [p-HTMOPPCu (II)] was synthes…
View article: Autophagy-Related Genes in Atherosclerosis
Autophagy-Related Genes in Atherosclerosis Open
Background. Atherosclerosis (AS) is a common chronic vascular inflammatory disease and one of the main causes of cardiovascular/cerebrovascular diseases (CVDs). Autophagy-related genes (ARGs) play a crucial part in pathophysiological proce…
View article: Study on the anti-inflammatory activity of chaga mushroom aqueous extract-alcohol precipitate
Study on the anti-inflammatory activity of chaga mushroom aqueous extract-alcohol precipitate Open
[Abstract]: Objective: To extract the active ingredient from chaga mushroom (aqueous extract-alcohol precipitates) to study its safety and anti-inflammatory activity. Methods: The aqueous extraction-alcohol precipitation method was used to…
View article: Microwave-assisted synthesis of ruthenium(<scp>ii</scp>) complexes containing levofloxacin-induced G2/M phase arrest by triggering DNA damage
Microwave-assisted synthesis of ruthenium(<span>ii</span>) complexes containing levofloxacin-induced G2/M phase arrest by triggering DNA damage Open
This study showed that levofloxacin-based ruthenium(ii) complex 2 effectively inhibited the growth of A549 cells by inducing G2/M phase arrest through triggering DNA damage.
View article: CCDC 1991921: Experimental Crystal Structure Determination
CCDC 1991921: Experimental Crystal Structure Determination Open
View article: CCDC 1991922: Experimental Crystal Structure Determination
CCDC 1991922: Experimental Crystal Structure Determination Open
View article: Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes Open
MiR-21, a non-coding miRNA with 22 nucleotides, plays an important part in the proliferation, invasion, and metastasis of tumor cells. The present study demonstrates that isomers of chiral ruthenium(II) complexes with alkynes (Λ-1 and Δ-1)…
View article: Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes Open
MiR-21, a non-coding miRNA with 22 nucleotides, plays an important part in the proliferation, invasion, and metastasis of tumor cells. The present study demonstrates that isomers of chiral ruthenium(II) complexes with alkynes (Λ-1 and Δ-1)…
View article: Additional file 2 of Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
Additional file 2 of Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes Open
Additional file 2. Raw data for RT-qPCR analysis.
View article: Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis
Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis Open
View article: Copper-catalyzed synthesis of phenol and diaryl ether derivatives <i>via</i> hydroxylation of diaryliodoniums
Copper-catalyzed synthesis of phenol and diaryl ether derivatives <i>via</i> hydroxylation of diaryliodoniums Open
A copper-catalysed hydroxylation of diaryliodoniums to generate phenols and diaryl ethers allows the synthesis of diversely functionalized phenols under mild reaction conditions and prepares diaryl ethers in a one-pot operation.
View article: Nucleus-enriched Ruthenium Polypyridine Complex Acts as a Potent Inhibitor to Suppress Triple-negative Breast Cancer Metastasis In vivo
Nucleus-enriched Ruthenium Polypyridine Complex Acts as a Potent Inhibitor to Suppress Triple-negative Breast Cancer Metastasis In vivo Open
View article: Correction: Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers
Correction: Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers Open
Correction for ‘Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers’ by Tianfeng Chen et al., Med. Chem. Commun., 2010, 1, 73–75.
View article: Preparation of Ru(<scp>ii</scp>)@oligonucleotide nanosized polymers as potential tumor-imaging luminescent probes
Preparation of Ru(<span>ii</span>)@oligonucleotide nanosized polymers as potential tumor-imaging luminescent probes Open
Ru(ii)@oligonucleotide nanoparticles can be developed as potential tumor selective tracker and have potential applications of tumor targeting imaging.
View article: Chiral ruthenium(<scp>ii</scp>) complex as potent radiosensitizer of<sup>125</sup>I through DNA-damage-mediated apoptosis
Chiral ruthenium(<span>ii</span>) complex as potent radiosensitizer of<sup>125</sup>I through DNA-damage-mediated apoptosis Open
SyntheticLR042can be further developed as a radiosensitizer of125I by inducing DNA-damage-mediated apoptosis for cancer therapy.