Mu‐Sheng Zeng
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View article: Corrigendum to The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
Corrigendum to The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells Open
View article: The m6A reader YTHDF1 facilitates nasopharyngeal carcinoma proliferation and migration via c-MYC
The m6A reader YTHDF1 facilitates nasopharyngeal carcinoma proliferation and migration via c-MYC Open
N6-methyladenosine (m6A), the most prevalent mRNA modification in eukaryotes, is critical for posttranscriptional regulation. The m6A reader YTH domain-containing family protein 1 (YTHDF1) acts as an oncogene in multiple malignancies, yet …
View article: Retraction Note: Vasculogenic mimicry formation in EBV-associated epithelial malignancies
Retraction Note: Vasculogenic mimicry formation in EBV-associated epithelial malignancies Open
View article: Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promote anti-viral innate immune evasion
Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promote anti-viral innate immune evasion Open
Viral strategies to antagonize the robust host innate immune response have a major function in the pathogenicity of viral infection and virus-associated cancers. Epstein-Barr virus (EBV) infection causes infectious mononucleosis (IM) and s…
View article: B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns
B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns Open
Vaccine development for pathogens has faced significant challenges, contributing to a public health burden. B‐cell epitope (BCE) prediction is a crucial process in vaccine development, but is hindered by limited efficiency and accuracy. To…
View article: Author Correction: Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
Author Correction: Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition Open
View article: Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development
Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development Open
Artificial intelligence (AI) is revolutionizing biotechnology by transforming the landscape of therapeutic development. Traditional drug discovery faces persistent challenges, including high attrition rates, billion‐dollar costs, and timel…
View article: Apo10 and TKTL1 in blood macrophages as non-invasive biomarkers for early detection of cervical cancer
Apo10 and TKTL1 in blood macrophages as non-invasive biomarkers for early detection of cervical cancer Open
Purpose Apo10 and TKTL1 are tumor-associated markers reflecting impaired apoptosis and enhanced glycolysis respectively. This study aimed to evaluate the diagnostic potential of Apo10, TKTL1, and APT (a combination of Apo10 and TKTL1) in s…
View article: Long Non‐Coding RNA <i>IGFRIL</i> Couples with PTBP1 to Destabilize <i>IGFBP3</i> mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma
Long Non‐Coding RNA <i>IGFRIL</i> Couples with PTBP1 to Destabilize <i>IGFBP3</i> mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma Open
The incomplete understanding of the IGFR pathway activation mechanism limits its clinical application in hepatocellular carcinoma (HCC). Here, a transcriptome‐wide screening is performed and a novel HCC‐associated lncRNA, named IGFR‐induci…
View article: Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition
Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition Open
Human herpesvirus 6B (HHV-6B), a β-herpesvirus that significantly threatens immunocompromised individuals, currently lacks targeted antiviral therapies or vaccines. Glycoprotein B (gB), the primary mediator of membrane fusion during viral …
View article: A genome-wide association study integrated with single-cell and bulk profiles uncovers susceptibility genes for nasopharyngeal carcinoma involved in tumorigenesis via regulation of T cells
A genome-wide association study integrated with single-cell and bulk profiles uncovers susceptibility genes for nasopharyngeal carcinoma involved in tumorigenesis via regulation of T cells Open
This study uncovers novel nasopharyngeal carcinoma susceptibility genes and their functional cell types, which improves the understanding of nasopharyngeal carcinoma genetic etiology.
View article: The PLEKHA1-TACC2 fusion gene drives tumorigenesis via vascular mimicry formation in esophageal squamous-cell carcinoma
The PLEKHA1-TACC2 fusion gene drives tumorigenesis via vascular mimicry formation in esophageal squamous-cell carcinoma Open
Despite advancements of diagnosis and multimodality therapies in esophageal squamous-cell carcinoma (ESCC), the survival is still unsatisfactory. Therefore, it is urgent to identify novel targets for efficient therapeutic strategies. Herei…
View article: OASL enhances mRNA translation and reprograms lipid metabolism to promote cancer progression
OASL enhances mRNA translation and reprograms lipid metabolism to promote cancer progression Open
Type I interferons (IFN-Is) are central coordinators of tumor-immune system interactions. Accumulating evidence suggests that persistent IFN-Is and a subset of IFN-stimulated genes (ISGs) might promote tumor development, but the regulation…
View article: Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma
Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma Open
The outcome of immune checkpoint blockade (ICB) therapy largely hinges on the antitumor immunity of tertiary lymphoid structures (TLSs), but drivers of tumor TLS formation remain exclusive. By integrating spatial transcriptomics and a pan-…
View article: R9AP is a common receptor for EBV infection in epithelial cells and B cells
R9AP is a common receptor for EBV infection in epithelial cells and B cells Open
Epstein-Barr virus (EBV) persistently infects more than 90% of the human population, causing infectious mononucleosis1, susceptibility to autoimmune diseases2 and multiple malignancies of epithelial or B cell-origin
View article: Curcumol targets the FTO/MAFG-AS1 axis to alleviate diabetic retinopathy <i>via</i> epigenetic remodeling and nanodelivery-based microenvironment modulation
Curcumol targets the FTO/MAFG-AS1 axis to alleviate diabetic retinopathy <i>via</i> epigenetic remodeling and nanodelivery-based microenvironment modulation Open
Diabetic retinopathy (DR) is a major microvascular complication of diabetes, with its pathogenesis involving metabolic memory, epigenetic dysregulation, and multi-cellular microenvironmental disorders. This study systematically investigate…
View article: Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma
Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma Open
To identify nasopharyngeal carcinoma (NPC)-relevant T cell receptors (TCRs), we profile the repertoires of peripheral blood TCRβ chains from 228 NPC patients, 241 at-risk controls positive for serum Epstein-Barr virus (EBV) VCA-IgA antibod…
View article: Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer
Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer Open
View article: Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B
Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B Open
Kaposi's sarcoma‐associated herpesvirus (KSHV), a member of the human γ‐herpesviruses family, exhibits extensive cellular tropism and is associated with Kaposi's sarcoma and various B‐cell malignancies. Despite its clinical significance, n…
View article: Transcriptome-wide Identification of GlycoRNAs by Clier-seq Pipeline
Transcriptome-wide Identification of GlycoRNAs by Clier-seq Pipeline Open
RNA molecules can undergo modification by N-glycans and be displayed on the cell surface. However, recent studies have focused primarily on N-glycan modifications on small RNAs less than 200 nt in length; the transcriptome-wide subtypes of…
View article: Inactivation of TACC2 epigenetically represses CDKN1A and confers sensitivity to CDK inhibitors
Inactivation of TACC2 epigenetically represses CDKN1A and confers sensitivity to CDK inhibitors Open
Funded by NKRDP, NSFC, GDIIET, GDBABRF, GDECISTP, and SYSUTP.
View article: Structural basis of Epstein-Barr virus gp350 receptor recognition and neutralization
Structural basis of Epstein-Barr virus gp350 receptor recognition and neutralization Open
Epstein-Barr virus (EBV) is an oncogenic virus associated with multiple lymphoid malignancies and autoimmune diseases. During infection in B cells, EBV uses its major glycoprotein gp350 to recognize the host receptor CR2, initiating viral …
View article: Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomas
Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomas Open
Lymphatic metastasis is a well-known factor for head and neck squamous cell carcinoma (HNSCC) that initiates distant metastasis, which caused major death in most patients with cancer. Metabolic reprogramming to support metastasis is regard…
View article: Unraveling coronavirus cell invasion: The role of glycan receptors in human coronavirus-HKU1 cell entry
Unraveling coronavirus cell invasion: The role of glycan receptors in human coronavirus-HKU1 cell entry Open
View article: A large-scale population-based study reveals that gp42-IgG antibody is protective against EBV–associated nasopharyngeal carcinoma
A large-scale population-based study reveals that gp42-IgG antibody is protective against EBV–associated nasopharyngeal carcinoma Open
BACKGROUNDEBV is associated with nasopharyngeal carcinoma (NPC), but the existence of a NPC protective antibody against EBV-associated antigens remains unclear.METHODSPatients with NPC and matched controls were identified from prospective …
View article: AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation Open
View article: Highly sensitive detection platform-based diagnosis of oesophageal squamous cell carcinoma in China: a multicentre, case–control, diagnostic study
Highly sensitive detection platform-based diagnosis of oesophageal squamous cell carcinoma in China: a multicentre, case–control, diagnostic study Open
For the Chinese translation of the abstract see Supplementary Materials section.
View article: Primary and Orthotopic Murine Models of Nasopharyngeal Carcinoma Reveal Molecular Mechanisms Underlying its Malignant Progression
Primary and Orthotopic Murine Models of Nasopharyngeal Carcinoma Reveal Molecular Mechanisms Underlying its Malignant Progression Open
Nasopharyngeal carcinoma (NPC), a squamous cell carcinoma originating in the nasopharynx, is a leading malignancy in south China and other south and east Asia areas. It is frequently associated with Epstein‐Barr virus (EBV) infection, whil…
View article: Discovering broader antiviral strategies: Role of interferon-induced transmembrane proteins in virus infection
Discovering broader antiviral strategies: Role of interferon-induced transmembrane proteins in virus infection Open
View article: A pan-KRAS degrader for the treatment of KRAS-mutant cancers
A pan-KRAS degrader for the treatment of KRAS-mutant cancers Open