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View article: PIPKI-PIP2 promotes cell migration by recruiting Smurf1 to the membrane and increasing its activity
PIPKI-PIP2 promotes cell migration by recruiting Smurf1 to the membrane and increasing its activity Open
View article: Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption
Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption Open
View article: The anti-phage mechanism of a widespread trypsin-MBL module
The anti-phage mechanism of a widespread trypsin-MBL module Open
Summary Protease mediate activation of immune effectors is a conserved mechanism across life. This study identified a widespread and co-evolving trypsin-MBL module as a core effector in diverse bacterial immune systems (e.g., Hachiman, Arg…
View article: Superior lubrication effect enabled by soluble carboxylated graphene quantum dots in polyether-modified silicone oil
Superior lubrication effect enabled by soluble carboxylated graphene quantum dots in polyether-modified silicone oil Open
View article: Structural Basis for Cas9-Directed Spacer Acquisition in Type II-A CRISPR-Cas Systems
Structural Basis for Cas9-Directed Spacer Acquisition in Type II-A CRISPR-Cas Systems Open
CRISPR-Cas systems confer prokaryotic adaptive immunity by integrating foreign DNA (prespacers) into host arrays. Type II-A systems employ Cas9 for protospacer adjacent motif (PAM) recognition and coordinate with Csn2 and the Cas1-Cas2 int…
View article: Leucine-rich repeat-containing 56 promotes breast cancer progression via modulation of the RhoA/ROCKs signaling axis
Leucine-rich repeat-containing 56 promotes breast cancer progression via modulation of the RhoA/ROCKs signaling axis Open
Breast cancer is one of the most common malignancies with a poor five-year survival rate with metastatic disease among women. It has well been documented that leucine-rich repeat-containing (LRRC) family of proteins are remarkably and aber…
View article: A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus
A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus Open
View article: Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption
Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption Open
Cyclic oligonucleotide-based antiphage signaling systems (CBASS) are widespread bacterial immune systems that trigger host suicide via cyclic nucleotide-activated effectors. The predominant strategy to induce cell death in CBASS is membran…
View article: Investigation of AMA Synthase from <i>Pyrenophora teres</i> f. <i>teres</i> 0–1 for the Synthesis of Aspergillomarasmine A Analogues and Non‐Canonical Amino Acids
Investigation of AMA Synthase from <i>Pyrenophora teres</i> f. <i>teres</i> 0–1 for the Synthesis of Aspergillomarasmine A Analogues and Non‐Canonical Amino Acids Open
The fungal natural product aspergillomarasmine A (AMA) is an inhibitor of metallo‐β‐lactamases and a promising co‐drug candidate for reversing bacterial β‐lactam resistance. The biosynthesis of AMA from L‐A sp and O ‐phospho‐L‐serine is ca…
View article: Comparison of risk scores for the prediction of 30-day mortality after TAVI on the basis of the MIMIC-IV database
Comparison of risk scores for the prediction of 30-day mortality after TAVI on the basis of the MIMIC-IV database Open
The aim of this study was to investigate the baseline characteristics of patients admitted to the ICU after TAVI and the ability of six scores (Acute physiology score III(APSIII), Sequential Organ Failure Assessment(SOFA), Logistic Organ D…
View article: The mechanism of bacterial defense system DdmDE from<i>Lactobacillus casei</i>
The mechanism of bacterial defense system DdmDE from<i>Lactobacillus casei</i> Open
Bacteria has developed a diverse array of defense mechanisms to protect against invasion by mobile genetic elements. Recent study identified a bacterial defense module DdmDE system which encodes a helicase-nuclease fusion protein DdmD and …
View article: Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)
Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV) Open
View article: Development of a prognostic nomogram for patients underwent extracorporeal circulation auxiliary to open cardiac surgery on hospital mortality: a retrospective cohort study
Development of a prognostic nomogram for patients underwent extracorporeal circulation auxiliary to open cardiac surgery on hospital mortality: a retrospective cohort study Open
Extracorporeal circulation; cardiac surgery; intensive care; nomogram; prediction model.
View article: Pollution Characteristics and Ecological Impact of Screening Analysis of Fishing Port Sediments from Dalian, North China
Pollution Characteristics and Ecological Impact of Screening Analysis of Fishing Port Sediments from Dalian, North China Open
Environmental pollution from synthetic chemical mixtures has significant adverse impacts on marine ecosystems. However, identifying the main constituents of chemical mixtures that pose ecological threats is challenging due to the necessity…
View article: Structure and genome editing of type I-B CRISPR-Cas
Structure and genome editing of type I-B CRISPR-Cas Open
Type I CRISPR-Cas systems employ multi-subunit effector Cascade and helicase-nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant RNA-guided adaptive immune systems in prokaryotes. Their ability to caus…
View article: The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13–MAPK–YWHAE signaling pathway
The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13–MAPK–YWHAE signaling pathway Open
Background Multiple myeloma (MM), an incurable disease owing to drug resistance, requires safe and effective therapies. Norcantharidin (NCTD), an active ingredient in traditional Chinese medicines, possesses activity against different canc…
View article: A neonatal case report of branchiooculofacial syndrome caused by a novel mutation in the TFAP2A gene and literature review
A neonatal case report of branchiooculofacial syndrome caused by a novel mutation in the TFAP2A gene and literature review Open
Rationale: Branchiooculofacial syndrome (BOFS) is a rare autosomal dominant disorder with a diverse clinical phenotype. To summarise the clinical characteristics and genetic variations of neonatal-onset BOFS through a case study and litera…
View article: Repurpose Type I-A CRISPR-Cas3 for a Robust HPV Diagnosis
Repurpose Type I-A CRISPR-Cas3 for a Robust HPV Diagnosis Open
R-loop-triggered collateral single-stranded DNA (ssDNA) nuclease activity within Class 1 Type I CRISPR-Cas systems holds immense potential for nucleic acid detection. However, the hyperactive ssDNase activity of Cas3 introduces unwanted no…
View article: Design of a chimeric glycosyltransferase OleD for the site‐specific O‐monoglycosylation of 3‐hydroxypyridine in nosiheptide
Design of a chimeric glycosyltransferase OleD for the site‐specific O‐monoglycosylation of 3‐hydroxypyridine in nosiheptide Open
To identify the potential role of the 3‐hydroxyl group of the pyridine ring in nosiheptide (NOS) for its antibacterial activity against Gram‐positive pathogens, enzymatic glycosylation was utilized to regio‐selectively create a monoglycosy…
View article: A novel type of facultative and plasminogen independent thrombolytic enzyme from the ancient marine organism, Sipunculus nudus
A novel type of facultative and plasminogen independent thrombolytic enzyme from the ancient marine organism, Sipunculus nudus Open
Thrombotic diseases have become a leading threat to global health, especially in the post-COVID-19 era. Current thrombolytic drugs are highly dependent on the activation of the human plasminogen. Herein we disclose a novel facultative and …
View article: Structural basis for auto-inhibition and activation of a short prokaryotic Argonaute associated TIR-APAZ defense system
Structural basis for auto-inhibition and activation of a short prokaryotic Argonaute associated TIR-APAZ defense system Open
Short prokaryotic Ago accounts for most prokaryotic Argonaute (pAgo) and is involved in defending bacteria against invading nucleic acids. Short prokaryotic Ago associated with APAZ-TIR (SPARTA) has been shown to oligomerize and deplete NA…
View article: Metabolomics Reveals Distinctive Metabolic Profiles and Marker Compounds of Camellia (Camellia sinensis L.) Bee Pollen
Metabolomics Reveals Distinctive Metabolic Profiles and Marker Compounds of Camellia (Camellia sinensis L.) Bee Pollen Open
Camellia bee pollen (CBP) is a major kind of bee product which is collected by honeybees from tea tree (Camellia sinensis L.) flowers and agglutinated into pellets via oral secretion. Due to its special healthcare value, the authenticity o…
View article: Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system
Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system Open
The type V-K CRISPR-associated transposons (CASTs) allow RNA-guided DNA integration and have great potential as a programmable site-specific gene insertion tool. Although all core components have been independently characterized structural…
View article: Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro)
Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro) Open
View article: Supplementary Figure 1 from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts
Supplementary Figure 1 from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts Open
Supplementary Figure 1 from Prostaglandin E2 Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose Fibroblasts
View article: Supplementary Figure 1 Legend from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts
Supplementary Figure 1 Legend from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts Open
Supplementary Figure 1 Legend from Prostaglandin E2 Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose Fibroblasts
View article: Supplementary Figure 1 Legend from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts
Supplementary Figure 1 Legend from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts Open
Supplementary Figure 1 Legend from Prostaglandin E2 Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose Fibroblasts
View article: Supplementary Figure 1 from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts
Supplementary Figure 1 from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts Open
Supplementary Figure 1 from Prostaglandin E2 Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose Fibroblasts
View article: Data from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts
Data from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts Open
Aromatase is the key enzyme for estrogen biosynthesis. A distal promoter, PI.4, maintains baseline levels of aromatase in normal breast adipose tissue. In contrast, malignant breast epithelial cells secrete prostaglandin E2 (PGE…
View article: Data from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts
Data from Prostaglandin E<sub>2</sub> Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH<sub>2</sub>-Terminal Kinase in Adipose Fibroblasts Open
Aromatase is the key enzyme for estrogen biosynthesis. A distal promoter, PI.4, maintains baseline levels of aromatase in normal breast adipose tissue. In contrast, malignant breast epithelial cells secrete prostaglandin E2 (PGE…