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View article: Sympathetic nerve inhibition enhances calvarial bone repair via senescent macrophage-induced osteogenesis and angiogenesis
Sympathetic nerve inhibition enhances calvarial bone repair via senescent macrophage-induced osteogenesis and angiogenesis Open
Bone regeneration is a tightly coordinated process involving multiple cellular and molecular components, with emerging evidence highlighting the pivotal role of the nervous system, especially the sympathetic nervous system, in modulating s…
View article: Single-cell mapping reveals age-related alterations in periosteal progenitor cells and immune microenvironment
Single-cell mapping reveals age-related alterations in periosteal progenitor cells and immune microenvironment Open
View article: Dynamic Fibrous Hydrogels for Stem Cell Homing and In Situ Bone Regeneration
Dynamic Fibrous Hydrogels for Stem Cell Homing and In Situ Bone Regeneration Open
Stem cell therapy holds great promise for enhancing bone regeneration, but its clinical outcomes are often hampered by ineffective cell homing and compromised paracrine activity in pathological oxidative microenvironments. Here, a dynamic …
View article: Single-Step Engineered Gelatin-Based Hydrogel for Integrated Prevention of Postoperative Adhesion and Promotion of Wound Healing
Single-Step Engineered Gelatin-Based Hydrogel for Integrated Prevention of Postoperative Adhesion and Promotion of Wound Healing Open
Postoperative adhesion remains a major clinical challenge, often leading to chronic pain, functional disorders, and recurrent surgeries. Herein, we developed a multifunctional gelatin–polyphenol hydrogel (GPP20) featuring rapid gelation (w…
View article: Causal Relationship Between Matrix Metalloproteinase and Cervical Lesions: A Two-Sample Mendelian Randomization Analysis
Causal Relationship Between Matrix Metalloproteinase and Cervical Lesions: A Two-Sample Mendelian Randomization Analysis Open
The study highlights causal associations between MMPs and cervical lesions, suggesting their potential as therapeutic targets and biomarkers for early detection. Future research should further explore the mechanisms involved.
View article: Bisphenol A causes melatonin biosynthesis epigenetic reprogramming of melatonin biosynthesis genes in arabidopsis thaliana
Bisphenol A causes melatonin biosynthesis epigenetic reprogramming of melatonin biosynthesis genes in arabidopsis thaliana Open
Bisphenol A (BPA) is a widely used chemical that is commonly found in soils and surface waters worldwide and acts as an oxidative stressor on plants. Our understanding of how BPA exposure affects cellular redox homeostasis remains limited.…
View article: Molecular Mechanistic Insights into Gel Elimination and Dissolution Enhancement of Small Molecular Drug: A Case Study of Lenvatinib Mesylate
Molecular Mechanistic Insights into Gel Elimination and Dissolution Enhancement of Small Molecular Drug: A Case Study of Lenvatinib Mesylate Open
View article: Massive acceleration of S <sub>N</sub> 2 reaction using the oriented external electric field
Massive acceleration of S <sub>N</sub> 2 reaction using the oriented external electric field Open
The S N 2 reaction, typically enhanced by polar solvents, can be accelerated using external electric fields within nanogaps in non-polar solvents.
View article: Sustainable Deep Eutectic Solvents Induced the Polymorph Selectivity and High Purification Efficiency
Sustainable Deep Eutectic Solvents Induced the Polymorph Selectivity and High Purification Efficiency Open
View article: CCDC 2262052: Experimental Crystal Structure Determination
CCDC 2262052: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire
Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire Open
View article: Establishment and identification of an animal model of Hirschsprung disease in suckling mice
Establishment and identification of an animal model of Hirschsprung disease in suckling mice Open
View article: [Retracted] Arnebin‑1 promotes angiogenesis by inducing eNOS, VEGF and HIF‑1α expression through the PI3K‑dependent pathway
[Retracted] Arnebin‑1 promotes angiogenesis by inducing eNOS, VEGF and HIF‑1α expression through the PI3K‑dependent pathway Open
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that the α‑tubulin protein bands shown in Fig. 2A on p. 689 were strikingly similar to data appearing in different form in the follo…
View article: Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis
Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis Open
View article: GSDMD-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis
GSDMD-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis Open
Dysregulated inflammation is closely associated with increased mortality in sepsis. Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, including the development of thrombosis, thrombocytopenia, and neut…
View article: Correction to: Reactive Oxygen Species–Responsive Celastrol-Loaded Bilirubin Nanoparticles for the Treatment of Rheumatoid Arthritis
Correction to: Reactive Oxygen Species–Responsive Celastrol-Loaded Bilirubin Nanoparticles for the Treatment of Rheumatoid Arthritis Open
View article: Mechanistic insight into gel-induced aggregation of amorphous curcumin during dissolution process
Mechanistic insight into gel-induced aggregation of amorphous curcumin during dissolution process Open
Amorphous curcumin (CUR) exhibited a decreased dissolution rate in comparison with the crystalline counterpart due to its gel formation during dissolution. The main purpose of the present study is to explore the mechanism of such gelation …
View article: Deaggregation and Crystallization Inhibition by Small Amount of Polymer Addition for a Co-Amorphous Curcumin-Magnolol System
Deaggregation and Crystallization Inhibition by Small Amount of Polymer Addition for a Co-Amorphous Curcumin-Magnolol System Open
Different from previously reported co-amorphous systems, a co-amorphous curcumin-magnolol (CUR-MAG CM) system, as compared with its crystalline counterparts, exhibited decreased dissolution due to its aggregation during dissolution. The ma…
View article: Therapeutic effect of pH-Responsive dexamethasone prodrug nanoparticles on acute lung injury
Therapeutic effect of pH-Responsive dexamethasone prodrug nanoparticles on acute lung injury Open
View article: Restoring the Platelet miR-223 by Calpain Inhibition Alleviates the Neointimal Hyperplasia in Diabetes
Restoring the Platelet miR-223 by Calpain Inhibition Alleviates the Neointimal Hyperplasia in Diabetes Open
Platelet hyperactivity is the hallmark of diabetes, and platelet activation plays a crucial role in diabetic vascular complications. Recent studies have shown that upon activation, platelet-derived miRNAs are incorporated into vascular smo…
View article: Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis
Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis Open
Rationale: Kawasaki disease (KD) is an acute vasculitis of early childhood that can result in permanent coronary artery structural damage. The cause for this arterial vulnerability in up to 15% of patients with KD is unknown. Vascular smoo…
View article: Wnt2bb Induces Cardiomyocyte Proliferation in Zebrafish Hearts via the jnk1/c-jun/creb1 Pathway
Wnt2bb Induces Cardiomyocyte Proliferation in Zebrafish Hearts via the jnk1/c-jun/creb1 Pathway Open
Previous studies have demonstrated that inhibition of canonical Wnt signaling promotes zebrafish heart regeneration and that treatment of injured heart tissue with the Wnt activator 6-bromo-indirubin-3-oxime (BIO) can impede cardiomyocyte …
View article: A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide
A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide Open
The coamorphous tadalafil–repaglinide (molar ratio, 1 : 1) prepared by solvent-evaporation method significantly improve the physicochemical properties of tadalafil and repaglinide.
View article: Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways Open
View article: Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC-β3/PKCδ-dependent pathway
Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC-β3/PKCδ-dependent pathway Open
View article: Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair
Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair Open
Upon arterial injury, endothelial denudation leads to platelet activation and delivery of multiple agents (e.g., TXA2, PDGF), promoting VSMC dedifferentiation and proliferation (intimal hyperplasia) during injury repair. The process of res…
View article: Characterization and Stability of Amorphous Tadalafil and Four Crystalline Polymorphs
Characterization and Stability of Amorphous Tadalafil and Four Crystalline Polymorphs Open
Tadalafil (TD), a phosphodiesterase-5 (PDE-5) inhibitor with poor oral bioavailability. The aim of the study was to prepare and characterize three crystalline polymorphs of TD (II, III, and IV) and the tadalafil amorphous form (TD-AM). TD …
View article: Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury
Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury Open
Salvia miltiorrhiza and ligustrazine are traditional Chinese medicines that have been used in combination for treatment of cardiovascular disease, including coronary heart disease, cardiac angina and atherosclerosis in Asia, in particular,…
View article: Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice
Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice Open
Zicao (Lithospermum erythrorhizon) has been used in clinics as a traditional Chinese medicine for thousands of years. Acetylshikonin (AS) is the main ingredient of Zicao, Xinjiang, China. The objective of this study was to investigate the …
View article: Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis
Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis Open
Various drugs have been developed to treat obesity, but these have undesirable secondary effects, and an efficient but non-toxic anti-obesity drug from natural sources is desired. This study investigated the anti-obesity effects and mechan…