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View article: Prevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori–Infected Patients Undergoing Upper Endoscopy
Prevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori–Infected Patients Undergoing Upper Endoscopy Open
INTRODUCTION: We designed a race-conscious study to assess the presence of Helicobacter pylori v irulence factor cagA in a retrospective cohort of patients with active H. pylori infection. METHODS: We compared cagA status by race in gastri…
View article: Type 2 Diabetes Mellitus and Helicobacter pylori Eradication in a Clinical Population
Type 2 Diabetes Mellitus and Helicobacter pylori Eradication in a Clinical Population Open
H. pylori eradication rates do not differ by T2DM status, providing support for clinical trials of H. pylori eradication to reduce GC incidence among high-risk populations in the United States, such as individuals with T2DM.
View article: Discrimination between Precancerous Gastric Lesions and Gastritis Using a Gastric Cancer Risk Stratification Model
Discrimination between Precancerous Gastric Lesions and Gastritis Using a Gastric Cancer Risk Stratification Model Open
Background: Seropositivity to certain Helicobacter pylori proteins may affect development of gastric lesions that could become cancerous. Previously, we developed a model of gastric cancer risk including gender, age, HP0305 seropositivity,…
View article: A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen
A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen Open
Background: Blood-based biomarkers for gastric cancer risk stratification could facilitate targeting screening to people who will benefit from it most. The ABC Method, which stratifies individuals by their Helicobacter pylori infection and…
View article: Cancer Progress and Priorities: Gastric Cancer—Reply
Cancer Progress and Priorities: Gastric Cancer—Reply Open
We thank Tavakkoli and colleagues for their interest in our recent review of gastric cancer progress and priorities (1), which included discussion of the higher gastric cancer incidence rates among all racial and ethnic minorities compared…
View article: Data from Smoking, <i>Helicobacter Pylori</i> Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea
Data from Smoking, <i>Helicobacter Pylori</i> Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea Open
Smoking is an established risk factor for gastric cancer development. In this study, we aimed to assess prospectively the association of smoking with gastric cancer risk in 1,446 non-cardia gastric cancer cases and 1,796 controls from Chin…
View article: Supplementary Tables S1-S3 from Smoking, <i>Helicobacter Pylori</i> Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea
Supplementary Tables S1-S3 from Smoking, <i>Helicobacter Pylori</i> Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea Open
Supplementary Table S1: Smoking and gastric cancer risk by time between blood draw and diagnosis, the H. pylori Biomarker Cohort Consortium (HpBCC) Supplementary Table S2: Smoking and gastric cancer risk by sex, the H. pylori Biomarker Coh…
View article: Data from Smoking, <i>Helicobacter Pylori</i> Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea
Data from Smoking, <i>Helicobacter Pylori</i> Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea Open
Smoking is an established risk factor for gastric cancer development. In this study, we aimed to assess prospectively the association of smoking with gastric cancer risk in 1,446 non-cardia gastric cancer cases and 1,796 controls from Chin…
View article: Cancer Progress and Priorities: Gastric Cancer
Cancer Progress and Priorities: Gastric Cancer Open
Gastric cancer, the fifth leading cause of cancer worldwide, is estimated to be responsible for approximately 1.4% of all new cancers and 1.8% of all cancer-related deaths in the United States. Despite declining incidence rates and improve…
View article: Supplementary Tables S1-S3 from Smoking, <i>Helicobacter Pylori</i> Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea
Supplementary Tables S1-S3 from Smoking, <i>Helicobacter Pylori</i> Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea Open
Supplementary Table S1: Smoking and gastric cancer risk by time between blood draw and diagnosis, the H. pylori Biomarker Cohort Consortium (HpBCC) Supplementary Table S2: Smoking and gastric cancer risk by sex, the H. pylori Biomarker Coh…
View article: Discrimination between Precancerous Gastric Lesions and Gastritis Using a Gastric Cancer Risk Stratification Model
Discrimination between Precancerous Gastric Lesions and Gastritis Using a Gastric Cancer Risk Stratification Model Open
The Lasso model for gastric cancer risk prediction can classify precancerous lesions with significantly greater AUC than the ABC Method and, at constant specificity, with greater sensitivity, PPV and NPV. However, adding age and gender to …
View article: Serum Pepsinogen as a Biomarker for Gastric Cancer in the United States: A Nested Case–Control Study Using the PLCO Cancer Screening Trial Data
Serum Pepsinogen as a Biomarker for Gastric Cancer in the United States: A Nested Case–Control Study Using the PLCO Cancer Screening Trial Data Open
Background: Gastric cancer lacks specific symptoms, resulting in diagnosis at later stages and high mortality. Serum pepsinogen is a biomarker for atrophic gastritis, a gastric cancer precursor, and may be useful to detect persons at incre…
View article: Serum antibodies to selected Helicobacter pylori antigens are associated with active gastritis in patients seen at the University Teaching Hospital in Lusaka, Zambia
Serum antibodies to selected Helicobacter pylori antigens are associated with active gastritis in patients seen at the University Teaching Hospital in Lusaka, Zambia Open
IntroductionLittle is known about specific bacterial characteristics of Helicobacter pylori (H. pylori) infection influencing gastric carcinogenesis in Zambia. The aim of this study was to evaluate the associations between pre-selected H. …
View article: Prediagnostic Antibody Responses to <i>Fusobacterium nucleatum</i> Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium
Prediagnostic Antibody Responses to <i>Fusobacterium nucleatum</i> Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium Open
Background: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established. Methods: We conducted a nested case–control study of 8,126 particip…
View article: Adverse childhood experiences and adult diet quality
Adverse childhood experiences and adult diet quality Open
Childhood trauma is strongly associated with poor health outcomes. Although many studies have found associations between adverse childhood experiences (ACEs), a well-established indicator of childhood trauma and diet-related health outcome…
View article: Immunostimulatory membrane proteins potentiate <i>H. pylori</i> -induced carcinogenesis by enabling CagA translocation
Immunostimulatory membrane proteins potentiate <i>H. pylori</i> -induced carcinogenesis by enabling CagA translocation Open
Infection with Helicobacter pylori is the single greatest risk factor for developing gastric adenocarcinoma. In prospective, population-based studies, seropositivity to the uncharacterized H. pylori proteins Hp0305 and Hp1564 was significa…
View article: Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer
Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer Open
Previously, we found that risk of colorectal cancer (CRC) is increased in individuals with serum antibody response to both Helicobacter pylori (HP) Vacuolating Cytotoxin (VacA) toxin or Streptococcus gallolyticus (SGG) pilus protein Gallo2…
View article: Auto-antibodies to p53 and the Subsequent Development of Colorectal Cancer in a U.S. Prospective Cohort Consortium
Auto-antibodies to p53 and the Subsequent Development of Colorectal Cancer in a U.S. Prospective Cohort Consortium Open
Background: Auto-antibodies to tumor suppressor p53 are found in a subset of patients with colorectal cancer. A recent prospective study in the United States has reported a significant 1.8-fold increased odds for colorectal cancer developm…
View article: Racial Differences in <i>Helicobacter pylori</i> CagA Sero-prevalence in a Consortium of Adult Cohorts in the United States
Racial Differences in <i>Helicobacter pylori</i> CagA Sero-prevalence in a Consortium of Adult Cohorts in the United States Open
Background: Prevalence of Helicobacter pylori (H. pylori) infection, the main risk factor for gastric cancer, has been decreasing in the United States; however, there remains a substantial racial disparity. Moreover, the time-trends for pr…
View article: The Durham Initiative for Stomach Health (DISH): a pilot community-based Helicobacter pylori education and screening study
The Durham Initiative for Stomach Health (DISH): a pilot community-based Helicobacter pylori education and screening study Open
Background Approximately 15% of all cancers are due to infection. The bacteria Helicobacter pylori is the single leading carcinogenic infectious agent and the main cause of stomach cancer. Prevalence of H. pylori , and, correspondingly, st…