Explanipedia

Connexin43 and Its Regulation of Astrocyte Gap Junction Function: Influencing Depression Progression by Mediating Electrical and Chemical Signals Open

Hongbin Wang, Cong Chen, Yuting Lin, Zhi-Feng Tian, Zihan Yan , et al. · 2025

Background Depression is a common mental illness with a high relapse rate, which has a serious negative impact on national economic development and happiness. At present, the pathogenesis of depression is still unclear, and there are inevi…

Dihydromyricetin treats pulmonary hypertension by modulating CKLF1/CCR5 axis-induced pulmonary vascular cell pyroptosis Open

Qian Yan, Ping Li, Shasha Liu, Yang Sun, Chen Chen , et al. · 2024

Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by elevated pulmonary artery pressure and vascular remodeling, resulting in poor prognosis and increased mortality rates. Chemokine-like factor 1 (CKLF1) pl…

Association Between Social Jetlag and Components of Metabolic Syndrome: A Systematic Review and Meta-Analysis Open

Meiyu Lin, Yi‐No Kang, Renny Wulan Apriliyasari, Pei‐Shan Tsai · 2024

Background A mismatch between biological and social time, often referred to as social jetlag (SJL), can lead to inadequate sleep and activities or taking meals at times that do not align with our biological rhythms, increasing the risk of …

RNA Sequencing Analysis of Changes in Pancreatic RNA in Tree Shrews with Traumatic Systemic Inflammatory Response Syndrome after Treatment with Umbilical Cord Mesenchymal Stem Cells Open

Guang‐Ping Ruan, Xiang Yao, Meiyu Lin, Shuqian Lin, Xinghua Pan · 2023

Background: Systemic inflammatory response syndrome (SIRS) is a systemic nonspecific inflammatory response to severe injury caused by infectious or noninfectious factors. Methods: The impact method was used to make unilateral femoral commi…

CC chemokines Modulate Immune responses in Pulmonary Hypertension Open

Qian Yan, Shasha Liu, Yang Sun, Chen Chen, Yantao Yang , et al. · 2023

In summary, the inquiry into the inflammatory responses mediated by CC chemokines and their corresponding receptors, and their potential in modulating immune reactions, holds promise as a prospective avenue for addressing PH. The potential…

Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions Open

Huiqin Wang, Xueying Yang, Huaqing Lai, Yang Sun, Yan Xu , et al. · 2023

Hypericin is widely utilized for its precise antidepressant properties, but its exact antidepressant mechanism remains unclear. Gap junctions, which were predominantly expressed in astrocytes in the central nervous system, are concerned wi…

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease Open

Yan Qian, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang , et al. · 2023

Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS…

Screening anti-fatigue components of American ginseng saponin by analyzing spectrum–effect relationship coupled with UPLC-Q-TOF-MS Open

Meiyu Lin, Shaiping Hu, Zeng Qi, Bixia Xiao, Yao He · 2023

Background American ginseng has an obvious anti-fatigue effect, but the effective material basis is still unclear. The spectrum–effect relationship is a scientific method that studies the correlations between chemical spectra and pharmacol…

Effectiveness of Cold Therapy for Pain and Anxiety Associated with Chest Tube Removal: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open

Hsin-Yi Lu, Meiyu Lin, Pei‐Shan Tsai, Hsiao‐Yean Chiu, Su‐Chen Fang · 2023

Targeting pyroptosis as a preventive and therapeutic approach for stroke Open

Junpeng Long, Yang Sun, Shasha Liu, Songwei Yang, Chen Chen , et al. · 2023

Stroke has caused tremendous social stress worldwide, yet despite decades of research and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue plasminogen activator) is still the accepted treatment for ischemic s…

A Review of Research on the Association between Neuron–Astrocyte Signaling Processes and Depressive Symptoms Open

Jiao Yao, Cong Chen, Yi Guo, Yantao Yang, Xinya Liu , et al. · 2023

Depression is a mental illness that has a serious negative impact on physical and mental health. The pathophysiology of depression is still unknown, and therapeutic medications have drawbacks, such as poor effectiveness, strong dependence,…

The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension Open

Yang Sun, Shasha Liu, Chen Chen, Songwei Yang, Gang Pei , et al. · 2023

New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases Open

Yang Sun, Yantao Yang, Shasha Liu, Songwei Yang, Chen Chen , et al. · 2022

Neurological diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity and often l…

Mechanism of Dihydromyricetin on Inflammatory Diseases Open

Yang Sun, Shasha Liu, Songwei Yang, Chen Chen, Yantao Yang , et al. · 2022

Inflammation plays a crucial role in a variety of diseases, including diabetes, arthritis, asthma, Alzheimer’s disease (AD), acute cerebral stroke, cancer, hypertension, and myocardial ischemia. Therefore, we need to solve the problem urge…

Correction: UPLC-MS/MS determination and pharmacokinetic study of 26-OH-panaxadiol in rat plasma Open

Meiyu Lin, Hongmei Gao, Jinping Liu, Han Liu, Qinghe Zhang , et al. · 2022

Correction for ‘UPLC-MS/MS determination and pharmacokinetic study of 26-OH-panaxadiol in rat plasma’ by Meiyu Lin et al. , Anal. Methods , 2013, 5 , 6656–6662, https://doi.org/10.1039/C3AY41320A.

Using phage-assisted continuous evolution (PACE) to evolve human PD1 Open

Xiaoxiao Ye, Min Tu, Mingxin Piao, Liang Yang, Zeng Zhou , et al. · 2020

PD1/PDL1 pathway plays a critical role in cancer immune responses. The immune checkpoint inhibitors of PD1/PDL1 have been well explored and developed for immunotherapies of solid tumors. Recently, various monoclonal antibodies targeting th…

Effect of small-dose ketamine combined with dexmedetomidine on emergence stress response as well as postoperative pain and Th cell deviation in patients with cervical cancer surgery under general anesthesian Open

Jin-Wen Gao, Meiyu Lin, Qun-Fei Zou, Jie-Lian Huang, Ming-Xiong Cheng · 2017

Objective: To study the effect of small-dose ketamine combined with dexmedetomidine on \nemergence stress response as well as postoperative pain and Th cell deviation in patients \nwith cervical cancer surgery under general anesthesia. Met…

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