Melanie Bunk
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View article: Discrimination and Precision of Continuous Glucose Monitoring in Staging Children With Presymptomatic Type 1 Diabetes
Discrimination and Precision of Continuous Glucose Monitoring in Staging Children With Presymptomatic Type 1 Diabetes Open
Context Staging and monitoring of presymptomatic type 1 diabetes includes the assessment for dysglycemia. Objective To assess the ability of continuous glucose monitoring (CGM) to differentiate between islet autoantibody-negative controls …
View article: SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood Open
Importance The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etio…
View article: Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial
Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial Open
View article: Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomized trial
Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomized trial Open
Background Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes with insulin autoimmunity often appearing in the first years of life. Here, oral insulin was given as a…
View article: Recruiting young pre-symptomatic children for a clinical trial in type 1 diabetes: Insights from the Fr1da insulin intervention study
Recruiting young pre-symptomatic children for a clinical trial in type 1 diabetes: Insights from the Fr1da insulin intervention study Open
View article: Efficacy of vildagliptin for prevention of postpartum diabetes in women with a recent history of insulin-requiring gestational diabetes: A phase II, randomized, double-blind, placebo-controlled study
Efficacy of vildagliptin for prevention of postpartum diabetes in women with a recent history of insulin-requiring gestational diabetes: A phase II, randomized, double-blind, placebo-controlled study Open
View article: miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity
miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity Open
Significance The onset of type 1 diabetes autoimmunity is indicated by the development of multiple islet autoantibodies, produced by B cells with the help of T follicular helper (TFH) cells. MicroRNAs (miRNAs) are small noncoding RNAs that…