Melanie Daue
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View article: Exonic Variation and Its Clinical Impact in 7221 Old Order Amish
Exonic Variation and Its Clinical Impact in 7221 Old Order Amish Open
The Amish of Lancaster County, PA has been the focus of genetic studies for many years due to its demographic history and unique genetic makeup that includes a historical bottleneck event and subsequent genetic drift, resulting in a marked…
View article: Randomized evaluation of the loss‐of‐function carboxylesterase 1 (<i>CES1</i>) <scp>G143E</scp> variant on clopidogrel and ticagrelor pharmacodynamics
Randomized evaluation of the loss‐of‐function carboxylesterase 1 (<i>CES1</i>) <span>G143E</span> variant on clopidogrel and ticagrelor pharmacodynamics Open
Antiplatelet therapy with a P2Y 12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers …
View article: Association of parity with body mass index and cardiometabolic risk in high-parous women
Association of parity with body mass index and cardiometabolic risk in high-parous women Open
Objective Postpregnancy weight retention contributes to obesity, but the long-term effect of parity on body mass index (BMI) and other cardiometabolic risk factors is unclear. We aimed to evaluate the relationship between parity and BMI am…
View article: 136 Sleep and Porphyromonas gingivalis K-Capsular IgG Serotypes: A Study in the Old Order Amish
136 Sleep and Porphyromonas gingivalis K-Capsular IgG Serotypes: A Study in the Old Order Amish Open
Introduction Sleep problems and periodontal disease have a bidirectional relationship and are independently linked with depression, dementia, and metabolic disease. Inadequate sleep can worsen inflammation, a hallmark of periodontal diseas…
View article: Risk factors for<i>Toxoplasma gondii</i>seropositivity in the Old Order Amish
Risk factors for<i>Toxoplasma gondii</i>seropositivity in the Old Order Amish Open
Toxoplasma gondii (T. gondii) is an important human disease-causing parasite. In the USA, T. gondii infects >10% of the population, accrues economic losses of US$3.6 billion/year, and ranks as the second leading culprit of foodborne illnes…
View article: <i>KCNQ1</i> and Long QT Syndrome in 1/45 Amish
<i>KCNQ1</i> and Long QT Syndrome in 1/45 Amish Open
Background: In population-based research exome sequencing, the path from variant discovery to return of results is not well established. Variants discovered by research exome sequencing have the potential to improve population health. Meth…
View article: Prevalence, control, and treatment of diabetes, hypertension, and high cholesterol in the Amish
Prevalence, control, and treatment of diabetes, hypertension, and high cholesterol in the Amish Open
Background The burden of diabetes and cardiovascular risk is not uniform across the USA, with much of this disparity tracking differences in socioeconomic status, cultural practices and lifestyle. To further evaluate disparities in these d…
View article: 1061 Problems During Daytime Due To Poor Sleep Are Associated With Indicators Of Poor Dental Health In A Largely Non-smoking Population
1061 Problems During Daytime Due To Poor Sleep Are Associated With Indicators Of Poor Dental Health In A Largely Non-smoking Population Open
Introduction Growing evidence connects periodontal disease, a major and modifiable cause of local and systemic inflammation, with metabolic and cardiovascular morbidity and mortality, as well as mental illness. Sleep has been previously pr…
View article: Toxoplasma gondii Serointensity and Seropositivity: Heritability and Household-Related Associations in the Old Order Amish
Toxoplasma gondii Serointensity and Seropositivity: Heritability and Household-Related Associations in the Old Order Amish Open
Toxoplasma gondii (T. gondii) is an intracellular parasite infecting one third of the world’s population. Latent T. gondii infection has been associated with mental illness, including schizophrenia and suicidal behavior. T. gondii IgG anti…
View article: 0061 Sleep Duration And Timing In Relationship to Toxoplasma Gondii Igg Serointensity In The Old Order Amish
0061 Sleep Duration And Timing In Relationship to Toxoplasma Gondii Igg Serointensity In The Old Order Amish Open
Disruption of sleep is associated with mental illness and suicidal behavior. Toxoplasma gondii (T. gondii), a neurotropic parasite has been linked with schizophrenia, mood disorders and suicidal behavior, and is able to synthetize dopamine…
View article: Toxoplasma gondii IgG associations with sleepwake problems, sleep duration and timing
Toxoplasma gondii IgG associations with sleepwake problems, sleep duration and timing Open
Background: Evidence links Toxoplasma gondii (T. gondii), a neurotropic parasite, with schizophrenia, mood disorders and suicidal behavior, all of which are associated and exacerbated by disrupted sleep. Moreover, low-grade immune activati…
View article: Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish
Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish Open
Summary Objectives Plasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Although plasma nitrites were previously linked with obesity and metabolic syndrome (MetS), the direction of as…
View article: 0424 Association between Toxoplasma Gondii Oocyst IgG And Insomnia In The Old Order Amish
0424 Association between Toxoplasma Gondii Oocyst IgG And Insomnia In The Old Order Amish Open
Toxoplasma gondii (T.gondii), infects central nervous tissue and is kept in relative dormancy by the immune system. Sleep disturbances were found to precipitate mental illness, suicidal behavior and car accidents, also previously linked to…
View article: Seasonality of blood neopterin levels in the Old Order Amish
Seasonality of blood neopterin levels in the Old Order Amish Open
Seasonal changes in non-human animals and seasonal affective disorder (SAD) in humans are associated with immune activation in winter relative to summer. We intended to measure seasonal variation in neopterin, a marker of cellular immunity…
View article: Positive association between <i>Toxoplasma gondii</i> IgG serointensity and current dysphoria/hopelessness scores in the Old Order Amish: a preliminary study
Positive association between <i>Toxoplasma gondii</i> IgG serointensity and current dysphoria/hopelessness scores in the Old Order Amish: a preliminary study Open
Toxoplasma gondii ( T. gondii ) IgG seropositivity and serointensity have been previously associated with suicidal self-directed violence (SSDV). Although associations with unipolar depression have also been investigated, the results have …