Michael L. Ginger
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View article: Two decades taken at speed: genomics, cell biology, ecology, and evolution of protists
Two decades taken at speed: genomics, cell biology, ecology, and evolution of protists Open
In dynamic scientific fields, two decades can be an eternity, with technical and conceptual advances leading to drastically changed landscapes and paradigms. Noted natural philosopher Ferris Bueller once opined, “Life moves pretty fast. If…
View article: Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world
Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world Open
Euglenoids (Euglenida) are unicellular flagellates possessing exceptionally wide geographical and ecological distribution. Euglenoids combine a biotechnological potential with a unique position in the eukaryotic tree of life. In large part…
View article: Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists
Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists Open
One peculiarity of protists belonging to classes Kinetoplastea and Diplonemea within the phylum Euglenozoa is compartmentalisation of most glycolytic enzymes within peroxisomes that are hence called glycosomes. This pathway is not sequeste…
View article: Euglena International Network (EIN): Driving euglenoids into the biotechnology world
Euglena International Network (EIN): Driving euglenoids into the biotechnology world Open
teaserEuglenoids show great promise to benefit our world; as biofuels, environmental remediators, anti-cancer agents, robotics design simulators and food nutritional agents, but the absence of reference genomes currently limit realizing th…
View article: CCDC 2005189: Experimental Crystal Structure Determination
CCDC 2005189: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2005190: Experimental Crystal Structure Determination
CCDC 2005190: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2005222: Experimental Crystal Structure Determination
CCDC 2005222: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2005132: Experimental Crystal Structure Determination
CCDC 2005132: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2005133: Experimental Crystal Structure Determination
CCDC 2005133: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2005221: Experimental Crystal Structure Determination
CCDC 2005221: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2005186: Experimental Crystal Structure Determination
CCDC 2005186: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties
Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties Open
One topical area of supramolecular chemistry is the binding of anionic species but despite the importance of anions in diverse cellular processes and for cancer development, anion receptors or ‘binders’ have received little attention as po…
View article: Divergent Cytochrome <i>c</i> Maturation System in Kinetoplastid Protists
Divergent Cytochrome <i>c</i> Maturation System in Kinetoplastid Protists Open
Cytochromes c are essential proteins for respiratory and photosynthetic electron transfer. They are posttranslationally modified by covalent attachment of a heme cofactor.
View article: Additional file 7 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 7 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 7: Table S5. Comparative genomic assessment of mitochondrial genes in Naegleria spp.
View article: Additional file 1 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 1 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 1: Table S1. % identity of SSU rRNA genes. Sheet 1: Naegleria species. Sheet 2: Selected tetrapod organisms.
View article: Additional file 10 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 10 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 10: Table S8. Comparative genomics analysis of Ras superfamily GTPases in Naegleria spp.
View article: Additional file 5 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 5 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 5: Table S3. Transcription factors in Naegleria spp.
View article: Additional file 12 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 12 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 12: Table S10. Differentially expressed genes following mouse-passage of N. fowleri LEE. Grey shading indicates genes found in N. fowleri alone or N. fowleri.
View article: Additional file 9 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 9 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 9: Table S7. Results of homology searching for membrane trafficking components in the predicted proteomes and genomes of N. fowleri V212, 39863, and 986.
View article: Additional file 18 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 18 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 18: Table S16. Predicted adhesion G protein-coupled receptors in Naegleria spp.
View article: Additional file 15 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 15 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 15: Table S13. Comparative genomic analysis of genes involved in autophagy in N. fowleri.
View article: Additional file 17 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 17 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 17: Table 15. Repeat domain-containing proteins in Naegleria spp. identified by BLAST search using human adhesion G protein-coupled receptors as queries.
View article: Additional file 13 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 13 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 13: Table S11. Comparative genomic analysis of proteases identified in Naegleria spp.
View article: Additional file 6 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 6 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 6: Table S4. Genes involved in sterol production in N. fowleri.
View article: Additional file 14 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 14 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 14: Table S12. Homology searching results for protease S81.
View article: Additional file 2 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Additional file 2 of Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri Open
Additional file 2: Table S2. Meiosis gene comparative genomics.