Melanie Lingaya
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View article: Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case–control study
Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case–control study Open
A lack of biomarkers that detect drug-induced liver injury (DILI) accurately continues to hinder early- and late-stage drug development and remains a challenge in clinical practice. The Innovative Medicines Initiative’s TransBioLine consor…
View article: Postinfective bowel dysfunction following <i>Campylobacter enteritis</i> is characterised by reduced microbiota diversity and impaired microbiota recovery
Postinfective bowel dysfunction following <i>Campylobacter enteritis</i> is characterised by reduced microbiota diversity and impaired microbiota recovery Open
Objectives Persistent bowel dysfunction following gastroenteritis (postinfectious (PI)-BD) is well recognised, but the associated changes in microbiota remain unclear. Our aim was to define these changes after gastroenteritis caused by a s…
View article: Pain Severity Correlates With Biopsy-Mediated Colonic Afferent Activation But Not Psychological Scores in Patients With IBS-D
Pain Severity Correlates With Biopsy-Mediated Colonic Afferent Activation But Not Psychological Scores in Patients With IBS-D Open
INTRODUCTION: Despite heterogeneity, an increased prevalence of psychological comorbidity and an altered pronociceptive gut microenvironment have repeatedly emerged as causative pathophysiology in patients with irritable bowel syndrome (IB…
View article: Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea—are we any closer? Authors' reply
Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea—are we any closer? Authors' reply Open
LINKED CONTENT This article is linked to Gunn et al and Black et al papers. To view these articles, visit https://doi.org/10.1111/apt.15420 and https://doi.org/10.1111/apt.15455 .
View article: Gastrointestinal peptides and small-bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease
Gastrointestinal peptides and small-bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease Open
View article: Abnormalities of mucosal serotonin metabolism and 5‐HT<sub>3</sub> receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron
Abnormalities of mucosal serotonin metabolism and 5‐HT<sub>3</sub> receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron Open
Summary Background Irritable bowel syndrome with diarrhoea (IBS‐D) is a common condition, greatly reducing the quality of life with few effective treatment options available. Aim To report the beneficial response shown in our trial with th…
View article: PTU-047 High prevalence of clostridium difficile ribotype 078 in IBD outpatients
PTU-047 High prevalence of clostridium difficile ribotype 078 in IBD outpatients Open
Background and Objectives Point prevalence studies have reported higher carriage rates of C. difficile in IBD patients compared with the general population, but longitudinal prospective data are lacking. The objectives of this obser…
View article: PTU-014 Effects of helicobacter pylori infection on iron metabolism genes in patients with iron deficiency anaemia
PTU-014 Effects of helicobacter pylori infection on iron metabolism genes in patients with iron deficiency anaemia Open
This is an accepted manuscript of an article published by BMJ in Gut on 08/06/2018, available online: http://dx.doi.org/10.1136/gutjnl-2018-BSGAbstracts.282
\nThe accepted version of the publication may differ from the final published ver…
View article: PWE-041 Alteration in small bowel motility, gut peptides and patient’s symptoms in active crohn’s disease
PWE-041 Alteration in small bowel motility, gut peptides and patient’s symptoms in active crohn’s disease Open
Introduction Intestinal inflammation in Crohn's disease (CD) is associated with an increase in Polypeptide YY (PYY), Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK). CD patients experience postprandial fullness and nausea. These …
View article: PWE-063 Alterations in cortical thickness and grey matter volume in patients with active crohn’s disease
PWE-063 Alterations in cortical thickness and grey matter volume in patients with active crohn’s disease Open
Introduction Changes in grey matter volume (GMV) and cortical thickness (CT) have been previously documented in adult Crohn's Disease (CD) patients in remission, however data is inconsistent and not explored in patients with active CD. Her…
View article: P006 Anatomical brain changes in active Crohn’s disease patients
P006 Anatomical brain changes in active Crohn’s disease patients Open
Changes in grey matter volume (GMV) and cortical thickness (CT) have been previously documented in adult Crohn’s disease (CD) patients in remission, however data are inconsistent and not explored in patients with active CD. Here, we invest…
View article: P099 Postprandial intestinal motility and related physiology in active small-bowel Crohn’s disease
P099 Postprandial intestinal motility and related physiology in active small-bowel Crohn’s disease Open
Magnetic Resonance Imaging (MRI) of small-bowel motility in Crohn’s disease (CD) is a sensitive disease activity biomarker and linked to patient symptoms1. Intestinal inflammation is associated with an increase in Polypeptide YY (PYY), Glu…
View article: <scp>MRI</scp> assessment of the postprandial gastrointestinal motility and peptide response in healthy humans
<span>MRI</span> assessment of the postprandial gastrointestinal motility and peptide response in healthy humans Open
Background Feeding triggers inter‐related gastrointestinal ( GI ) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI advances allow pan‐intestinal, non‐invasive assessment…
View article: Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: A randomized crossover study
Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: A randomized crossover study Open
Aim To investigate the acute and longer‐term effects of low ( LGI ) versus high glycaemic index ( HGI ) diets on hepatic fat and glycogen accumulation and related blood measures in healthy volunteers. Methods Eight healthy men (age 20.1 ± …
View article: Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomized controlled trial
Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomized controlled trial Open
View article: A mechanistic multicentre, parallel group, randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D)
A mechanistic multicentre, parallel group, randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D) Open
NCT01316718.
View article: Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial
Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial Open
Background Diarrhoea-predominant irritable bowel syndrome (IBS-D) is a common outcome after inflammation due to bacterial gastroenteritis. Several studies have shown ongoing immune activation in the mucosa of patients with IBS-D and a numb…
View article: Effect of experimental stress on the small bowel and colon in healthy humans
Effect of experimental stress on the small bowel and colon in healthy humans Open
Background Symptoms of irritable bowel syndrome ( IBS ) are frequently reported to be exacerbated by stress. Animal studies suggest that corticotrophin releasing hormone ( CRH ) mediates the effect of stress on the bowel. We have shown tha…