Melanie M. Callaghan
YOU?
Author Swipe
View article: Lipid membrane remodeling and metabolic response during isobutanol and ethanol exposure in Zymomonas mobilis
Lipid membrane remodeling and metabolic response during isobutanol and ethanol exposure in Zymomonas mobilis Open
View article: Deuterated water as a substrate-agnostic isotope tracer for investigating reversibility and thermodynamics of reactions in central carbon metabolism
Deuterated water as a substrate-agnostic isotope tracer for investigating reversibility and thermodynamics of reactions in central carbon metabolism Open
View article: The Gonococcal Genetic Island defines distinct sub-populations of Neisseria gonorrhoeae
The Gonococcal Genetic Island defines distinct sub-populations of Neisseria gonorrhoeae Open
The incidence of gonorrhoea is increasing at an alarming pace, and therapeutic options continue to narrow as a result of worsening drug resistance. Neisseria gonorrhoeae is naturally competent, allowing the organism to adapt rapidly to sel…
View article: Novel computational and experimental approaches for investigating the thermodynamics of metabolic networks
Novel computational and experimental approaches for investigating the thermodynamics of metabolic networks Open
View article: Expression, Localization, and Protein Interactions of the Partitioning Proteins in the Gonococcal Type IV Secretion System
Expression, Localization, and Protein Interactions of the Partitioning Proteins in the Gonococcal Type IV Secretion System Open
Partitioning proteins are well studied as molecular organizers of chromosome and plasmid segregation during division, however little is known about the roles partitioning proteins can play within type IV secretion systems. The single-stran…
View article: Hostile Takeover: How Viruses Reprogram Prokaryotic Metabolism
Hostile Takeover: How Viruses Reprogram Prokaryotic Metabolism Open
To reproduce, prokaryotic viruses must hijack the cellular machinery of their hosts and redirect it toward the production of viral particles. While takeover of the host replication and protein synthesis apparatus has long been considered a…
View article: Transcriptional and translational responsiveness of the<i>Neisseria gonorrhoeae</i>type IV secretion system to conditions of host infections
Transcriptional and translational responsiveness of the<i>Neisseria gonorrhoeae</i>type IV secretion system to conditions of host infections Open
The type IV secretion system of Neisseria gonorrhoeae translocates single-stranded DNA into the extracellular space, facilitating horizontal gene transfer and initiating biofilm formation. Expression of this system has been observed to be …
View article: Protein interactions within and between two F‐type type IV secretion systems
Protein interactions within and between two F‐type type IV secretion systems Open
Bacterial type IV secretion systems (T4SSs) can mediate conjugation. The T4SS from Neisseria gonorrhoeae possesses the unique ability to mediate DNA secretion into the extracellular environment. The N. gonorrhoeae T4SS can be grouped with …
View article: Mucus Is a Key Factor in Neisseria meningitidis Commensalism
Mucus Is a Key Factor in Neisseria meningitidis Commensalism Open
The work presented by Audry et al. (M. Audry, C. Robbe-Masselot, J.-P. Barnier, B. Gachet, et al., mSphere 4:e00494-19, 2019, https://doi.org/10.1128/mSphere.00494-19 ) gives new insight into the interactions of Neisseria meningitidis and …
View article: Antigenic Variation in <i>Neisseria gonorrhoeae</i> Occurs Independently of RecQ-Mediated Unwinding of the <i>pilE</i> G Quadruplex
Antigenic Variation in <i>Neisseria gonorrhoeae</i> Occurs Independently of RecQ-Mediated Unwinding of the <i>pilE</i> G Quadruplex Open
The pathogenic bacteria Neisseria gonorrhoeae avoids clearance by the immune system through antigenic variation (AV), the process by which immunogenic surface features of the bacteria are exchanged for novel variants. RecQ helicase is crit…
View article: Secretion of Chromosomal DNA by the Neisseria gonorrhoeae Type IV Secretion System
Secretion of Chromosomal DNA by the Neisseria gonorrhoeae Type IV Secretion System Open
View article: Targeted mutagenesis of intergenic regions in the <scp><i>N</i></scp><i>eisseria gonorrhoeae</i> gonococcal genetic island reveals multiple regulatory mechanisms controlling type <scp>IV</scp> secretion
Targeted mutagenesis of intergenic regions in the <span><i>N</i></span><i>eisseria gonorrhoeae</i> gonococcal genetic island reveals multiple regulatory mechanisms controlling type <span>IV</span> secretion Open
Summary Gonococci secrete chromosomal DNA into the extracellular environment using a type IV secretion system ( T4SS ). The secreted DNA acts in natural transformation and initiates biofilm development. Although the DNA and its effects are…