Melanie Reschke
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View article: Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination
Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination Open
An inhalable platform for messenger RNA (mRNA) therapeutics would enable minimally invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung-targeted mRNA therapeutics has been limited by poor transfection e…
View article: Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission. Parenteral vaccines induce robust systemic immunity but poor immun…
View article: Nucleic Acid Delivery to the Vascular Endothelium
Nucleic Acid Delivery to the Vascular Endothelium Open
This Review examines the state-of-the-art in the delivery of nucleic acid therapies that are directed to the vascular endothelium. First, we review the most important homeostatic functions and properties of the vascular endothelium and sum…
View article: Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion
Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion Open
Background Improved treatment of glioblastoma (GBM) needs to address tumor invasion, a hallmark of the disease that remains poorly understood. In this study, we profiled GBM invasion through integrative analysis of histological and single-…
View article: Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination
Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination Open
An inhalable platform for mRNA therapeutics would enable minimally invasive and lung targeted delivery for a host of pulmonary diseases. Development of lung targeted mRNA therapeutics has been limited by poor transfection efficiency and ri…
View article: Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses
Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses Open
As the SARS-CoV-2 pandemic enters its third year, vaccines that not only prevent disease, but also prevent transmission are needed to help reduce global disease burden. Currently approved parenteral vaccines induce robust systemic immunity…
View article: A digital pathology tool for quantification of color features in histologic specimens
A digital pathology tool for quantification of color features in histologic specimens Open
In preclinical research, histological analysis of tissue samples is often limited to qualitative or semiquantitative scoring assessments. The reliability of this analysis can be impaired by the subjectivity of these approaches, even when r…
View article: Lysis of cold-storage-induced microvascular obstructions for ex vivo revitalization of marginal human kidneys
Lysis of cold-storage-induced microvascular obstructions for ex vivo revitalization of marginal human kidneys Open
View article: Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression
Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression Open
Tissue engineering may address organ shortages currently limiting clinical transplantation. Off-the-shelf engineered vascularized organs will likely use allogeneic endothelial cells (ECs) to construct microvessels required for graft perfus…