Melanie Schott
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View article: Effects of carvedilol on human prostate tissue contractility and stromal cell growth pointing to potential clinical implications
Effects of carvedilol on human prostate tissue contractility and stromal cell growth pointing to potential clinical implications Open
View article: The Vanishing Clinical Value of PD-L1 Status as a Predictive Biomarker in the First-Line Treatment of Urothelial Carcinoma of the Bladder
The Vanishing Clinical Value of PD-L1 Status as a Predictive Biomarker in the First-Line Treatment of Urothelial Carcinoma of the Bladder Open
Background: Our study endeavors to elucidate the clinical implications of PD-L1 positivity in individuals afflicted with advanced urothelial carcinoma of the bladder (UCB). Methods: Patients with advanced UCB were prospectively enrolled fo…
View article: Propensity score-matched evaluation of palliative transurethral resection and holmium laser enucleation of the prostate for bladder outlet obstruction in patients with prostate cancer
Propensity score-matched evaluation of palliative transurethral resection and holmium laser enucleation of the prostate for bladder outlet obstruction in patients with prostate cancer Open
View article: Table of Contents
Table of Contents Open
View article: OPENSTREETMAP ELEMENT VECTORISATION - A TOOL FOR HIGH RESOLUTION DATA INSIGHTS AND ITS USABILITY IN THE LAND-USE AND LAND-COVER DOMAIN
OPENSTREETMAP ELEMENT VECTORISATION - A TOOL FOR HIGH RESOLUTION DATA INSIGHTS AND ITS USABILITY IN THE LAND-USE AND LAND-COVER DOMAIN Open
OpenStreetMap offers manifold possibilities for spatial analysis and location based services. However, fitness for purpose is a commonly discussed issue. As external datasets of high quality are frequently missing, many assessments rely on…
View article: Strategies to successfully prevent COVID-19 outbreak in vulnerable uro-oncology patient population
Strategies to successfully prevent COVID-19 outbreak in vulnerable uro-oncology patient population Open
View article: How does symptom severity impact clinical outcomes of men with lower urinary tract symptoms after holmium laser enucleation or transurethral resection of the prostate?
How does symptom severity impact clinical outcomes of men with lower urinary tract symptoms after holmium laser enucleation or transurethral resection of the prostate? Open
Patients with severe LUTS were more likely to experience clinically significant improvement after surgery than patients with moderate LUTS, and HoLEP showed superior functional outcomes than TURP. However, patients with moderate LUTS shoul…
View article: 68Ga-EMP-100 PET/CT—a novel ligand for visualizing c-MET expression in metastatic renal cell carcinoma—first in-human biodistribution and imaging results
68Ga-EMP-100 PET/CT—a novel ligand for visualizing c-MET expression in metastatic renal cell carcinoma—first in-human biodistribution and imaging results Open
View article: Polyethylene glycol-coated collagen patch (hemopatch®) in open partial nephrectomy
Polyethylene glycol-coated collagen patch (hemopatch®) in open partial nephrectomy Open
View article: How obesity affects the benefits of holmium laser enucleation of the prostate for the treatment of male lower urinary tract symptoms
How obesity affects the benefits of holmium laser enucleation of the prostate for the treatment of male lower urinary tract symptoms Open
Objectives: Holmium laser enucleation of the prostate (HoLEP) can be used regardless of prostate size and offers durable long-term results for patients suffering from lower urinary tract symptoms (LUTS)/benign prostatic obstruction (BPO), …
View article: Holmium laser enucleation of the prostate: A truly size‐independent method?
Holmium laser enucleation of the prostate: A truly size‐independent method? Open
Objectives To evaluate the impact of prostate size on functional outcomes and perioperative morbidity, we analyzed patients undergoing holmium laser enucleation of the prostate (HoLEP) for lower urinary tract symptoms (LUTS). As LUTS secon…
View article: Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on 18F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression
Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on 18F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression Open
We present a 71-year-old female patient who underwent 18F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. 18F-PSMA-1007 PET/CT showed a high PSMA-avi…
View article: Safety and Efficacy of Robotic Radiosurgery for Visceral and Lymph Node Metastases of Renal Cell Carcinoma: A Retrospective, Single Center Analysis
Safety and Efficacy of Robotic Radiosurgery for Visceral and Lymph Node Metastases of Renal Cell Carcinoma: A Retrospective, Single Center Analysis Open
Despite rapid advances of systemic therapy options in renal cell carcinoma (RCC), local tumor or metastases treatment remains important in selected patients. Here, we assess the safety and efficacy of robotic radiosurgery (RRS) as an ablat…
View article: The impact of preoperative lower urinary tract symptoms medication on the functional performance of holmium laser enucleation of the prostate
The impact of preoperative lower urinary tract symptoms medication on the functional performance of holmium laser enucleation of the prostate Open
Although preoperative LUTS medication does not impair efficacy of HoLEP with acceptable perioperative morbidity, the time gap between medical therapy and surgical treatment may favor an earlier response.
View article: The clinical value of holmium laser enucleation of the prostate in octogenarians
The clinical value of holmium laser enucleation of the prostate in octogenarians Open
Objectives With holmium laser enucleation of the prostate (HoLEP) a size‐independent method for surgical treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic obstruction (BPO) has been introduced. HoLEP offers dur…
View article: Enucleation vs. resection: A matched-pair analysis of TURP, HoLEP and bipolar TUEP
Enucleation vs. resection: A matched-pair analysis of TURP, HoLEP and bipolar TUEP Open
View article: HoLEP vs. TURP for patients with medium-sized prostates (50cc) treated for male LUTS - a matched-pair analysis
HoLEP vs. TURP for patients with medium-sized prostates (50cc) treated for male LUTS - a matched-pair analysis Open
View article: Safety and efficacy of Cyberknife radiosurgery for visceral and lymph node metastases of renal cell carcinoma – a retrospective, single center analysis
Safety and efficacy of Cyberknife radiosurgery for visceral and lymph node metastases of renal cell carcinoma – a retrospective, single center analysis Open
View article: PD08-12 CYBERKNIFE RADIOSURGERY AS A SAFE AND EFFECTIVE TREATMENT OPTION FOR VISCERAL AND LYMPH NODE METASTASES OF RENAL CELL CARCINOMA
PD08-12 CYBERKNIFE RADIOSURGERY AS A SAFE AND EFFECTIVE TREATMENT OPTION FOR VISCERAL AND LYMPH NODE METASTASES OF RENAL CELL CARCINOMA Open
You have accessJournal of UrologyKidney Cancer: Localized: Ablative Therapy (PD08)1 Apr 2020PD08-12 CYBERKNIFE RADIOSURGERY AS A SAFE AND EFFECTIVE TREATMENT OPTION FOR VISCERAL AND LYMPH NODE METASTASES OF RENAL CELL CARCINOMA Severin Rod…
View article: Real-World Results from One Year of Therapy with Tivozanib
Real-World Results from One Year of Therapy with Tivozanib Open
We report our one-year experience on the use of Tivozanib in metastatic Renal Cell Carcinoma (RCC) in n=23 patients treated within a year after approval. Tumor response according to RECIST criteria was PR in 39.1%, SD in 52.2% and PD in 8.…
View article: Sequential Treatment Based on Sunitinib and Sorafenib in Patients with Metastatic Renal Cell Carcinoma
Sequential Treatment Based on Sunitinib and Sorafenib in Patients with Metastatic Renal Cell Carcinoma Open
None of the therapeutic first-line approaches was superior to the other. Sequencing tyrosine kinase inhibitor (TKI) therapy seems to be effective in mRCC and superior to single-line therapy. Further studies should focus on the efficacy of …
View article: Effekte des Phosphodiesterase 10A-Inhibitors TC-E 5005 auf den glattmuskulären Tones der humanen Prostata
Effekte des Phosphodiesterase 10A-Inhibitors TC-E 5005 auf den glattmuskulären Tones der humanen Prostata Open
View article: Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus
Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus Open
A central question to biology is how pathogenic bacteria initiate acute or chronic infections. Here we describe a genetic program for cell-fate decision in the opportunistic human pathogen Staphylococcus aureus, which generates the phenoty…
View article: Inhibition of smooth muscle contraction and ARF6 activity by the inhibitor for cytohesin GEFs, secinH3, in the human prostate
Inhibition of smooth muscle contraction and ARF6 activity by the inhibitor for cytohesin GEFs, secinH3, in the human prostate Open
Prostate smooth muscle contraction is critical for etiology and treatment of male lower urinary tract symptoms (LUTS) and is promoted by small monomeric GTPases (RhoA and Rac). GTPases may be activated by guanosine nucleotide exchange fact…
View article: Author response: Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus
Author response: Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract A central question to biology…
View article: MP44-18 INHIBITION OF SMOOTH MUSCLE CONTRACTION BY THE INHIBITOR FOR CYTOHESIN FAMILIY GUANOSINE NUCLEOTIDE EXCHANGE FACTORS, SECIN H3 IN THE HYPERPLASTIC HUMAN PROSTATE
MP44-18 INHIBITION OF SMOOTH MUSCLE CONTRACTION BY THE INHIBITOR FOR CYTOHESIN FAMILIY GUANOSINE NUCLEOTIDE EXCHANGE FACTORS, SECIN H3 IN THE HYPERPLASTIC HUMAN PROSTATE Open
You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology1 Apr 2016MP44-18 INHIBITION OF SMOOTH MUSCLE CONTRACTION BY THE INHIBITOR FOR CYTOHESIN FAMILIY GUANOSINE NUCLEOTIDE EXCHANGE FACTORS, SECIN H3…
View article: MP44-14 INHIBITION OF ADRENERGIC AND NON-ADRENERGIC SMOOTH MUSCLE CONTRACTION IN THE HYPERPLASTIC HUMAN PROSTATE BY THE PHOSPHODIESTERASE 10-SELECTIVE INHIBITOR TC-E 5005
MP44-14 INHIBITION OF ADRENERGIC AND NON-ADRENERGIC SMOOTH MUSCLE CONTRACTION IN THE HYPERPLASTIC HUMAN PROSTATE BY THE PHOSPHODIESTERASE 10-SELECTIVE INHIBITOR TC-E 5005 Open
You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology1 Apr 2016MP44-14 INHIBITION OF ADRENERGIC AND NON-ADRENERGIC SMOOTH MUSCLE CONTRACTION IN THE HYPERPLASTIC HUMAN PROSTATE BY THE PHOSPHODIESTER…
View article: Mapping of the CFH domain interacting with HcpA.
Mapping of the CFH domain interacting with HcpA. Open
(A) Purified recombinant HcpA protein was separated by SDS-PAGE and transferred to nitrocellulose membranes. The membrane strips were incubated with either normal human serum (NHS), recombinant CFHL-1 (CFHSCR 1-7), several delet…