Mélanie Tobin
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View article: The role of inhibitory neurons in novelty sound detection in regular and random statistical contexts
The role of inhibitory neurons in novelty sound detection in regular and random statistical contexts Open
Detecting statistical regularities in sound and responding to violations of these patterns, termed novelty detection, is a core function of the auditory system. In the human brain, studies have shown that novelty responses are enhanced in …
View article: “Distinct inhibitory neurons differently shape neuronal codes for sound intensity in the auditory cortex”
“Distinct inhibitory neurons differently shape neuronal codes for sound intensity in the auditory cortex” Open
Cortical circuits contain multiple types of inhibitory neurons which shape how information is processed within neuronal networks. Here, we asked whether somatostatin-expressing (SST) and vasoactive intestinal peptide-expressing (VIP) inhib…
View article: Putting the Pieces Together: the Hair Cell Transduction Complex
Putting the Pieces Together: the Hair Cell Transduction Complex Open
View article: Machanical Frequency Tuning by the Hair Bundle of Mechanosensory Hair Cells
Machanical Frequency Tuning by the Hair Bundle of Mechanosensory Hair Cells Open
View article: Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles
Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles Open
Significance Each of the sensory receptors responsible for hearing or balance—a hair cell—has a mechanosensitive hair bundle. Mechanical stimuli pull upon molecular filaments—the tip links—that open ionic channels in the hair bundle. Loud …
View article: Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles
Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles Open
Hearing and balance rely on the capacity of mechanically sensitive hair bundles to transduce vibrations into electrical signals that are forwarded to the brain. Hair bundles possess tip links that interconnect the mechanosensitive stereoci…
View article: Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea
Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea Open
Sound analysis by the cochlea relies on frequency tuning of mechanosensory hair cells along a tonotopic axis. To clarify the underlying biophysical mechanism, we have investigated the micromechanical properties of the hair cell’s mechanore…
View article: Author response: Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea
Author response: Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea Open
View article: Tonotopy of the mammalian cochlea is associated with stiffness and tension gradients of the hair cell’s tip-link complex
Tonotopy of the mammalian cochlea is associated with stiffness and tension gradients of the hair cell’s tip-link complex Open
Frequency analysis of sound by the cochlea relies on sharp frequency tuning of mechanosensory hair cells along a tonotopic axis. To clarify the underlying biophysical mechanism, we have investigated the micromechanical properties of t he h…
View article: Gradients in the mechanical properties of auditory hair cells
Gradients in the mechanical properties of auditory hair cells Open
Notre capacite a communiquer et a apprecier la musique repose sur une discrimination de frequences couvrant une large gamme de frequences sonores. Cette propriete resulte de cellules mecanosensorielles « ciliees », qui sont reglees pour re…
View article: Control of a hair bundle’s mechanosensory function by its mechanical load
Control of a hair bundle’s mechanosensory function by its mechanical load Open
Significance Hair bundles are the sensory antennae that detect different types of mechanical signals in diverse sensory systems of vertebrates. Here we design and use a mechanical-load clamp to show that the mechanical properties of hair b…
View article: Characterization of active hair-bundle motility by a mechanical-load clamp
Characterization of active hair-bundle motility by a mechanical-load clamp Open
Active hair-bundle motility endows hair cells with several traits that augment auditory stimuli. The activity of a hair bundle might be controlled by adjusting its mechanical properties. Indeed, the mechanical properties of bundles vary be…