Explanipedia

Computational Design of a TCR-Based Bispecific Engager Targeting Cancerous KRAS G12V Mutations Open

Nishit Shah, Gargi Sharma, Virendra I. Patel, Melinda Wu, Anishreddy Mummadi , et al. · 2025

Bi-Specific T-Cell Engager (BiTE) Therapy is a type of immunotherapy that redirects cytotoxic T-cells to target tumor cells. Traditionally, a BiTE structure dual binds to the CD3 receptor on the T-cell surface and to the mutated antigen pr…

In Silico Design of Blinatumomab: A conventional Bispecific T Cell Engager for Targeted Immunotherapy Open

Nishit Shah, Gargi Sharma, Virendra I. Patel, Giang Le, Melinda Wu , et al. · 2025

Blinatumomab is an FDA-approved bispecific T Cell engager(BiTE) that binds CD3 on T cells and CD19 on B cells, redirecting cytotoxic T cell activity to malignant B cells. Blinatumomab has achieved clinical success in treating B-cell acute …

In Silico Design of Blinatumomab: A conventional Bispecific T Cell Engager for Targeted Immunotherapy Open

Nishit Shah, Gargi Sharma, Virendra I. Patel, Giang Le, Melinda Wu , et al. · 2025

Blinatumomab is an FDA-approved bispecific T Cell engager(BiTE) that binds CD3 on T cells and CD19 on B cells, redirecting cytotoxic T cell activity to malignant B cells. Blinatumomab has achieved clinical success in treating B-cell acute …

Sociodemographic Characteristics of Patients Seen at Vascular Anomaly Centers in the United States Open

Bryan A. Sisk, Whitney Eng, Jamie M. Aye, Joana M. Mack, Andrew Tran , et al. · 2025

Patients with vascular anomalies (VAs) require expert multidisciplinary care. No prior studies have characterized the sociodemographic characteristics across multiple VA centers. We collected data on 5783 patients receiving care at 20 VA c…

Preparation and Electrochemical Performance Study of Mno2/3d Nitrogen-Doped Reduced Graphene Oxide Open

Min Wu, Melinda Wu, Yue Yao, Xin Zhang · 2025

Enhancing the care experiences of Black women along the breast cancer journey: Meaningfully engaging breast cancer survivors to co-create a targeted, culturally relevant resource hub Open

Ayan Hashi, Rumaisa Khan, Abigal Appiahene-Afriyie, D. G. Barker, Talina Higgins , et al. · 2023

There is very little tailored and culturally relevant information available for Black women in Canada around breast cancer. For those who are diagnosed, and who undergo their own breast cancer journey, many feel isolated while navigating c…

Treatment practices and response in Kaposiform hemangioendothelioma: a multi-center cohort study Open

Alexandra J. Borst, Whitney Eng, Morgan Griffin, Kiersten Ricci, Elissa Engel , et al. · 2023

Background and Objectives: Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are rare vascular tumors in children historically associated with significant morbidity and mortality. This study was conducted to determine first lin…

Elevated LDL Cholesterol Increases Microvascular Endothelial VWF and Thromboinflammation After Myocardial Infarction Open

Koya Ozawa, William Packwood, Oleg Varlamov, Matthew Muller, Aris Xie , et al. · 2023

Background: In reperfused myocardial infarction, VWF (von Willebrand factor)-mediated platelet adhesion contributes to impaired microvascular reflow and possibly also to postmyocardial infarction inflammation. We hypothesized that postisch…

Increased Susceptibility for Adverse Reactions to Ultrasound Enhancing Agents in Sickle Cell Disease Open

Melinda Wu, Joshua Fields, Vandana Sachdev, J. Todd Belcik, Junmei Chen , et al. · 2022

Towards a Postgraduate Oncology Training Model for Family Medicine: Mixed Methods Evaluation of a Breast Oncology Rotation Open

Michelle B. Nadler, Brooke E. Hofbauer, Melinda Wu, Susan Hum, Christine Elser , et al. · 2022

Background: Family physicians have low knowledge and preparedness to manage patients with cancer. A breast oncology clinical rotation was developed for family medicine residents to address this gap in medical education. Objectives and Meth…

<i>DNMT3A</i>overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults Open

Margaret A. Ferris, Amanda M. Smith, Sharon E. Heath, Eric J. Duncavage, Matthew J. Oberley , et al. · 2021

DNMT3A overgrowth syndrome (DOS, also known as Tatton-Brown-Rahman Syndrome [TBRS]) is an overgrowth syndrome caused by de novo germline mutations in the gene encoding the de novo DNA-methyltransferase 3A (DNMT3A).2][3][4] Affected individ…

Arterial Thrombotic Complications of Tyrosine Kinase Inhibitors Open

Melinda Wu, Javid J. Moslehi, Jonathan R. Lindner · 2020

Abnormal expression or function of several classes of kinases contribute to the development of many types of solid and hematologic malignancies. TKs (tyrosine kinases) in particular play a role in tumor growth, metastasis, neovascularizati…

Echocardiographic Molecular Imaging of the Effect of Anticytokine Therapy for Atherosclerosis Open

Weihui Shentu, Koya Ozawa, The Anh Nguyen, Melinda Wu, William Packwood , et al. · 2020

Ponatinib coronary microangiopathy: novel bedside diagnostic approach and management with N-acetylcysteine Open

Melinda Wu, James Hodovan, Kurraboyina S.V.S.S. Kumar, Bart Moulton, Sven R. Olson , et al. · 2020

Key Points Ponatinib produces a coronary microangiopathy that mimics myocardial infarction and can be detected rapidly by contrast echocardiography. N-acetylcysteine therapy can potentially resolve ischemic complications caused by ponatini…

Contrast-Enhanced Ultrasound to Detect Early Microvascular Changes in Skeletal Muscle after High-Dose Radiation Treatment Open

Nima Nabavizadeh, Yue Qi, Andy Kaempf, Yiyi Chen, James A. Tanyi , et al. · 2019

The biological response of normal tissue to high-dose radiation treatment remains poorly understood. Alterations to the microenvironment, specifically the microvasculature, have been implicated as a significant contributor to tumoral cytot…

Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib Open

Yllka Latifi, Federico Moccetti, Melinda Wu, Aris Xie, William Packwood , et al. · 2019

The third-generation tyrosine kinase inhibitor (TKI) ponatinib has been associated with high rates of acute ischemic events. The pathophysiology responsible for these events is unknown. We hypothesized that ponatinib produces an endothelia…

Molecular Imaging of VWF (von Willebrand Factor) and Platelet Adhesion in Postischemic Impaired Microvascular Reflow Open

Koya Ozawa, William Packwood, Oleg Varlamov, Yue Qi, Aris Xie , et al. · 2018

Background: Complete mechanistic understanding of impaired microvascular reflow after myocardial infarction will likely lead to new therapies for reducing infarct size. Myocardial contrast echocardiography perfusion imaging and molecular i…

Lipoprotein Apheresis Acutely Reverses Coronary Microvascular Dysfunction in Patients With Severe Hypercholesterolemia Open

Melinda Wu, Federico Moccetti, Eran Brown, Brian P. Davidson, Tamara Atkinson , et al. · 2018

Skeletal and myocardial microvascular blood flow in hydroxycarbamide‐treated patients with sickle cell disease Open

Vandana Sachdev, Stanislav Sidenko, Melinda Wu, Caterina P. Minniti, Hwaida Hannoush , et al. · 2017

Summary In sickle cell disease ( SCD ), abnormal microvascular function combined with chronic anaemia predisposes patients to perfusion‐demand mismatch. We hypothesized that skeletal muscle and myocardial perfusion, normalized to the degre…

Platelets and von Willebrand factor in atherogenesis Open

Melinda Wu, Tamara Atkinson, Jonathan R. Lindner · 2017

The role of platelet adhesion, activation, and aggregation in acute atherothrombotic events such as myocardial infarction and stroke is well established. There is increasing evidence that platelet-endothelial interactions also contribute t…

Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling Open

J. Todd Belcik, Brian P. Davidson, Aris Xie, Melinda Wu, Mrinal Yadava , et al. · 2017

Background: Augmentation of tissue blood flow by therapeutic ultrasound is thought to rely on convective shear. Microbubble contrast agents that undergo ultrasound-mediated cavitation markedly amplify these effects. We hypothesized that pu…

Physician and Patient Barriers to Breast Cancer Preventive Therapy Open

Susan Hum, Melinda Wu, Sandhya Pruthi, Ruth Heisey · 2016

Influence of DNA-Microbubble Coupling on Contrast Ultrasound–Mediated Gene Transfection in Muscle and Liver Open

Aris Xie, Melinda Wu, Gabriella Cigarroa, J. Todd Belcik, Azzdine Y. Ammi , et al. · 2016

Endocardial Endothelial Dysfunction Progressively Disrupts Initially Anti then Pro-Thrombotic Pathways in Heart Failure Mice Open

Amanda Schoner, Christina Tyrrell, Melinda Wu, Jill M. Gelow, Alicia Hayes , et al. · 2015

CREBA133 mice develop HF and endocardial endothelial dysfunction. Attenuation of the anti-coagulant APC pathway promotes endocardial thrombosis in early and acute decompensated phases of HF. However, in stable compensated HF mice, disrupti…

Temporal Assessment of Regional and Remote Non Tumor Microvascular Response to High Dose Radiation Therapy Using Contrast Enhanced Ultrasound Open

Nima Nabavizadeh, Melinda Wu, Yan Xi, Alexios Martin, James A. Tanyi , et al. · 2015

Abnormal Regulation of Microvascular Tone in a Murine Model of Sickle Cell Disease Assessed by Contrast Ultrasound Open

Melinda Wu, J. Todd Belcik, Yue Qi, Yan Zhao, Cameron Benner , et al. · 2015

Melinda Wu YOU? Author Swipe