Melinda Wuest
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View article: Synthesis and Evaluation of Theranostic Mono- and Bivalent UniCAR T – Bombesin Peptide Conjugates in Prostate Cancer
Synthesis and Evaluation of Theranostic Mono- and Bivalent UniCAR T – Bombesin Peptide Conjugates in Prostate Cancer Open
View article: PET Imaging of Autotaxin in Multiple Sclerosis (MS)
PET Imaging of Autotaxin in Multiple Sclerosis (MS) Open
View article: Novel chelators for radiolanthanum coordination chemistry
Novel chelators for radiolanthanum coordination chemistry Open
View article: Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of <sup>18</sup> F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3
Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of <sup>18</sup> F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3 Open
The muscarinic acetylcholine receptor subtype M3 is validated as a promising target for imaging and therapy in breast cancer. Transcriptomic and proteomic profiling reveal its overexpression, particularly in triple‐negative breast cancer. …
View article: Decadentate Acyclic Chelators for Lanthanum Radiopharmaceuticals
Decadentate Acyclic Chelators for Lanthanum Radiopharmaceuticals Open
Two decadentate acyclic chelators bearing four picolinic acid groups appended on either an ethylenediamine (H4TPAEN) or a trans-1,2-cyclohexyldiamine (H4TPADAC) unit were explored as candidates for lanthanum-ba…
View article: Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity
Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity Open
Many individuals with type 2 diabetes (T2D) cannot take current therapies due to their adverse effects. Thus, new glucose-lowering agents targeting unique mechanisms are needed. Studies have demonstrated that decreasing ketone oxidation, s…
View article: Tackling Prostate Cancer with Theranostic E5B9-Bombesin Target Modules (TMs): From Imaging to Treatment with UniCAR T-Cells
Tackling Prostate Cancer with Theranostic E5B9-Bombesin Target Modules (TMs): From Imaging to Treatment with UniCAR T-Cells Open
Target modules (TMs), intermediate molecules required for UniCAR T-cell therapy, are promising molecules for immunotheranostic approaches. In the current work, we developed TMs containing a monomeric or dimeric form of the antagonist bombe…
View article: Development and clinical potential of <sup>18</sup>F-PSiMA for prostate cancer PET imaging
Development and clinical potential of <sup>18</sup>F-PSiMA for prostate cancer PET imaging Open
Optimized SiFA-PSMA radiotracer, 18 F-PSiMA, offers increased tumor uptake compared to previous lead compound, and negligible bone and salivary gland uptake.
View article: SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with 203Pb-PSC-panitumumab in NRG mice
SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with 203Pb-PSC-panitumumab in NRG mice Open
Panitumumab was successfully and reproducibly labelled with 203Pb in high radiochemical purity using the chelator PSC-NCS. 203Pb-PSC-panitumumab was specifically accumulated and retained in EGFR + tumours in NRG mice …
View article: Immuno-PET Imaging of EGFR with <sup>64</sup>Cu-NOTA Panitumumab in Subcutaneous and Metastatic Nonsmall Cell Lung Cancer Xenografts
Immuno-PET Imaging of EGFR with <sup>64</sup>Cu-NOTA Panitumumab in Subcutaneous and Metastatic Nonsmall Cell Lung Cancer Xenografts Open
Objective: About 65-90% of nonsmall cell lung cancer (NSCLC) express the epithelial growth factor receptor (EGFR) as a transmembrane protein that is activated by binding of specific ligands, including epidermal growth factor and tra…
View article: <i>N</i>-Alkyl Carbamoylimidazoles as Versatile Synthons for the Synthesis of Urea-Based PSMA Inhibitors
<i>N</i>-Alkyl Carbamoylimidazoles as Versatile Synthons for the Synthesis of Urea-Based PSMA Inhibitors Open
We describe N-alkyl carbamoylimidazoles as readily available and highly versatile synthons for synthesizing urea-based prostate-specific membrane antigen (PSMA) inhibitors. Urea formation proceeded in high yields (>80%) at room temp…
View article: Figure S4 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S4 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Immunohistochemistry staining for ATX and Bcl-2 in mouse breast tumor and tumor-adjacent adipose. A: ATX staining in tumors. B: ATX staining in tumor-adjacent adipose. C: Bcl-2 staining in tumors. Scale bar = 100 mm.
View article: Figure S5 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S5 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
ATX activity in conditioned media of Hs578Bst stromal fibroblasts and patient-matching Hs578T breast cancer cells. Cells were exposed to different doses of g-radiation and ATX activity was measured 24 h after irradiation. n=3 to 5 for each…
View article: Figure S3 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S3 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
H&E and immunohistochemistry staining for ATX and Bcl-2 in mouse breast tumor tissue. The border between tumor (red T) and stromal tissue (red S) is showed as red dash line. Scale bar = 100 mm.
View article: Data from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Data from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Autotaxin catalyzes the formation of lysophosphatidic acid, which stimulates tumor growth and metastasis and decreases the effectiveness of cancer therapies. In breast cancer, autotaxin is secreted mainly by breast adipocytes, especially w…
View article: Figure S7 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S7 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Protein levels of cytokines in tumor adjacent adipose tissue with or without irradiation and/or GLPG1690. n = 5 in control, n = 6 in other groups.
View article: Figure S2 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S2 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Immunohistochemistry images for Ki67. A: Ki67 staining in tumors treated with GLPG1690 in combination with RT. B: Ki67 staining in tumors treated with GLPG1690 in combination with doxorubicin. Scale bar = 100 mm.
View article: Figure S6 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S6 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Protein levels of cytokines in tumors with or without irradiation and/or GLPG1690. n = 5 in control, n = 6 in other groups. * P<0.05, ** P<0.01, ***P<0.001.
View article: Data from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Data from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Autotaxin catalyzes the formation of lysophosphatidic acid, which stimulates tumor growth and metastasis and decreases the effectiveness of cancer therapies. In breast cancer, autotaxin is secreted mainly by breast adipocytes, especially w…
View article: Figure S7 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S7 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Protein levels of cytokines in tumor adjacent adipose tissue with or without irradiation and/or GLPG1690. n = 5 in control, n = 6 in other groups.
View article: Figure S1 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S1 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Body weight of mice A: Body weight of mice before and after treatment with GLPG1690 in combination with radiation. n = 5 to 6 mice per group. B: Body weight of mice before and after treatment with GLPG1690 in combination with doxorubicin. …
View article: Figure S3 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S3 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
H&E and immunohistochemistry staining for ATX and Bcl-2 in mouse breast tumor tissue. The border between tumor (red T) and stromal tissue (red S) is showed as red dash line. Scale bar = 100 mm.
View article: Figure S2 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S2 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Immunohistochemistry images for Ki67. A: Ki67 staining in tumors treated with GLPG1690 in combination with RT. B: Ki67 staining in tumors treated with GLPG1690 in combination with doxorubicin. Scale bar = 100 mm.
View article: Figure S6 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S6 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Protein levels of cytokines in tumors with or without irradiation and/or GLPG1690. n = 5 in control, n = 6 in other groups. * P<0.05, ** P<0.01, ***P<0.001.
View article: Figure S5 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S5 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
ATX activity in conditioned media of Hs578Bst stromal fibroblasts and patient-matching Hs578T breast cancer cells. Cells were exposed to different doses of g-radiation and ATX activity was measured 24 h after irradiation. n=3 to 5 for each…
View article: Figure S1 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S1 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Body weight of mice A: Body weight of mice before and after treatment with GLPG1690 in combination with radiation. n = 5 to 6 mice per group. B: Body weight of mice before and after treatment with GLPG1690 in combination with doxorubicin. …
View article: Figure S4 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Figure S4 from Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Open
Immunohistochemistry staining for ATX and Bcl-2 in mouse breast tumor and tumor-adjacent adipose. A: ATX staining in tumors. B: ATX staining in tumor-adjacent adipose. C: Bcl-2 staining in tumors. Scale bar = 100 mm.
View article: PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[18F]fluoro-6-deoxy-D-fructose
PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[18F]fluoro-6-deoxy-D-fructose Open
Fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[18F]FDF) targets the fructose-preferred facilitative hexose transporter GLUT5, which is expressed predominantly in brain microglia and activated in response to inflammatory stimuli. We hy…
View article: PET imaging of fructose metabolism in a rodent model of neuroinflammation with 6-[ 18F]fluoro-6-deoxy-D-fructose
PET imaging of fructose metabolism in a rodent model of neuroinflammation with 6-[ 18F]fluoro-6-deoxy-D-fructose Open
Introduction: Fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[ 18 F]FDF) was developed for PET imaging of fructose metabolism in breast cancer via the fructose-preferred facilitative hexose transporter, GLUT5. In the brain, GLUT5 is pr…
View article: Peroxisome Injury in Multiple Sclerosis: Protective Effects of 4-Phenylbutyrate in CNS-Associated Macrophages
Peroxisome Injury in Multiple Sclerosis: Protective Effects of 4-Phenylbutyrate in CNS-Associated Macrophages Open
Multiple sclerosis (MS) is a progressive and inflammatory demyelinating disease of the CNS. Peroxisomes perform critical functions that contribute to CNS homeostasis. We investigated peroxisome injury and mitigating effects of peroxisome-r…