Melissa B. Jones
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View article: 0892 Prodromal Parkinsonism in post-9/11 Veterans with Probable REM Sleep Behavior Disorder: A Pilot Study
0892 Prodromal Parkinsonism in post-9/11 Veterans with Probable REM Sleep Behavior Disorder: A Pilot Study Open
Introduction Rapid eye movement (REM) sleep behavior disorder (RBD) is the single strongest predictor of Parkinson’s disease (PD) risk. Given neurotrauma and psychiatric morbidity, the aging post-9/11 Veteran cohort is a target population …
View article: 0893 Expert Annotation of Free-text Descriptions of Dream Enactment Behaviors Associated with REM Sleep Behavior Disorder
0893 Expert Annotation of Free-text Descriptions of Dream Enactment Behaviors Associated with REM Sleep Behavior Disorder Open
Introduction We developed a database of free-text descriptions of dream enactment behavior (DEBs) from unstructured clinical notes of Veterans with electronic diagnoses of rapid eye movement sleep behavior disorder (RBD). We additionally e…
View article: Poststroke Impulsivity: A Narrative Review
Poststroke Impulsivity: A Narrative Review Open
In this narrative review, the authors examine the multidimensional nature and presentations of impulsivity after stroke. Impulsivity manifests as immediate or premature responses, impaired delayed gratification, perseverance despite punish…
View article: Rates and Predictors of Rapid Eye Movement Sleep Behavior Disorder Symptoms Among Post-9/11 Veterans
Rates and Predictors of Rapid Eye Movement Sleep Behavior Disorder Symptoms Among Post-9/11 Veterans Open
Interdisciplinary parasomnia assessment, further validation of RBD screens, and standardized reporting of REM sleep without atonia could provide necessary information on the pathophysiological relationships linking PTSD, TBI, RBD symptoms,…
View article: 0700 Identifying Rapid Eye Movement Sleep Behavior Disorder in Veterans Administrative Databases: A Validation Study
0700 Identifying Rapid Eye Movement Sleep Behavior Disorder in Veterans Administrative Databases: A Validation Study Open
Introduction As a first step toward phenotyping large numbers of Veterans with rapid eye movement (REM) sleep behavior disorder (RBD), we investigated the ability of ICD-9 (327.42) and ICD-10 (G47.52) codes to detect Veterans with this cli…
View article: 0145 Worsening ESS Thresholds Predict Five-year Mortality Risk: An NLP-informed Model
0145 Worsening ESS Thresholds Predict Five-year Mortality Risk: An NLP-informed Model Open
Introduction The Epworth Sleepiness Scale (ESS) is a validated tool for capturing self-reported excessive daytime sleepiness. We examined thresholds for association between ESS changes and risk of 5-year all-cause mortality. Methods ESS va…
View article: 0357 Pimavanserin 34mg at Bedtime for Insomnia in Veterans with Post-traumatic Stress Disorder: Open-label Case Series
0357 Pimavanserin 34mg at Bedtime for Insomnia in Veterans with Post-traumatic Stress Disorder: Open-label Case Series Open
Introduction There is a critical need for effective and feasible interventions to address insomnia associated with post-traumatic stress disorder (PTSD). Several lines of evidence suggest that pimavanserin, a 5-HT2A inverse agonist approve…
View article: 0663 Rates and Predictors of Rapid Eye Movement Sleep Behavior Disorder Symptoms in Post-9/11 Veterans
0663 Rates and Predictors of Rapid Eye Movement Sleep Behavior Disorder Symptoms in Post-9/11 Veterans Open
Introduction Post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI), both prevalent conditions in post-9/11 Veterans, have been linked to rapid eye movement sleep behavior disorder (RBD). We administered a validated screeni…
View article: Developmental care pathway for hospitalised infants with CHD: on behalf of the Cardiac Newborn Neuroprotective Network, a Special Interest Group of the Cardiac Neurodevelopmental Outcome Collaborative
Developmental care pathway for hospitalised infants with CHD: on behalf of the Cardiac Newborn Neuroprotective Network, a Special Interest Group of the Cardiac Neurodevelopmental Outcome Collaborative Open
Infants and children born with CHD are at significant risk for neurodevelopmental delays and abnormalities. Individualised developmental care is widely recognised as best practice to support early neurodevelopment for medically fragile inf…
View article: Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature
Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature Open
Neuroimaging is widely utilized in studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). The risk for PTSD is greater after TBI than after non-TBI trauma, and PTSD is associated with worse outcomes after TBI. Stu…
View article: 0052 A mixed-methods examination of perceived challenges during the COVID-19 pandemic: Associations with sleep health and nightmares among healthcare workers
0052 A mixed-methods examination of perceived challenges during the COVID-19 pandemic: Associations with sleep health and nightmares among healthcare workers Open
Introduction The emergence of CoVID-19 has created an immense burden on healthcare systems across the world, placing healthcare workers (HCWs) under significant, additional stress while they also confront multiple personal, family and soci…
View article: Neuroimaging correlates of syndromal depression following traumatic brain injury: A systematic review of the literature
Neuroimaging correlates of syndromal depression following traumatic brain injury: A systematic review of the literature Open
Objective To complete a systematic review of the literature examining neuroimaging findings unique to co-occurring syndromal depression in the setting of TBI. Methods A PRISMA compliant literature search was conducted in PubMed (MEDLINE), …
View article: Cefiderocol for the Treatment of Adult and Pediatric Patients With Cystic Fibrosis and <i>Achromobacter xylosoxidans</i> Infections
Cefiderocol for the Treatment of Adult and Pediatric Patients With Cystic Fibrosis and <i>Achromobacter xylosoxidans</i> Infections Open
Treatment options for Achromobacter xylosoxidans are limited. Eight cystic fibrosis patients with A. xylosoxidans were treated with 12 cefiderocol courses. Pretreatment in vitro resistance was seen in 3 of 8 cases. Clinical response occurr…
View article: Neuropsychiatric Symptoms in Elderly With Dementia During COVID-19 Pandemic: Definition, Treatment, and Future Directions
Neuropsychiatric Symptoms in Elderly With Dementia During COVID-19 Pandemic: Definition, Treatment, and Future Directions Open
NPS of dementia during COVID-19 appear to arise from social restrictions occurring as a consequence of the pandemic. Implementation of caregiver support and the presence of skilled nursing home staff are required to restore social interact…
View article: Severe illness getting noticed sooner – SIGNS-for-Kids: developing an illness recognition tool to connect home and hospital
Severe illness getting noticed sooner – SIGNS-for-Kids: developing an illness recognition tool to connect home and hospital Open
Background Delays to definitive treatment for time-sensitive acute paediatric illnesses continue to be a cause of death and disability in the Canadian healthcare system. Our aim was to develop the SIGNS-for-Kids illness recognition tool to…
View article: Hypoplastic left heart syndrome: from fetus to fontan
Hypoplastic left heart syndrome: from fetus to fontan Open
The care of children with hypoplastic left heart syndrome is constantly evolving. Prenatal diagnosis of hypoplastic left heart syndrome will aid in counselling of parents, and selected fetuses may be candidates for in utero intervention. F…