Melissa Badding
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View article: Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study
Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study Open
The CLARITY-BPA Core Study is the most comprehensive animal study of oral bisphenol A (BPA) exposure to date. Rats were exposed daily, in utero until postnatal day 21 or for the animals’ lifetime. While the study authors concluded that sev…
View article: Toxicological risk assessment of bisphenol a released from dialyzers under simulated-use and exaggerated extraction conditions
Toxicological risk assessment of bisphenol a released from dialyzers under simulated-use and exaggerated extraction conditions Open
Bisphenol A (BPA) belongs to a group of chemicals used in the production of polycarbonate, polysulfone, and polyethersulfone which are used, among other applications, in the manufacture of dialyzers. While exposure to BPA is widespread in …
View article: <i>In vivo</i> mutagenicity evaluation of the soil fumigant 1,3-dichloropropene
<i>In vivo</i> mutagenicity evaluation of the soil fumigant 1,3-dichloropropene Open
1,3-Dichloropropene (1,3-D; CAS No. 542-75-6) is a soil fumigant used for the control of nematodes in agriculture. There is an extensive database on the genotoxicity of 1,3-D and many of the published studies are confounded by the presence…
View article: CLARITY-BPA Core Study: Analysis for non-monotonic dose-responses and biological relevance
CLARITY-BPA Core Study: Analysis for non-monotonic dose-responses and biological relevance Open
The results of a large 2-year bisphenol A (BPA) rat study conducted by the NTP, called the CLARITY-BPA Core Study, were recently released. This study addressed some of the toxicological issues associated with BPA, including endocrine disru…
View article: Application of the ICRP respiratory tract model to estimate pulmonary retention of industrially sampled indium-containing dusts
Application of the ICRP respiratory tract model to estimate pulmonary retention of industrially sampled indium-containing dusts Open
Inhalation of indium-containing dusts is associated with the development of indium lung disease. Workers may be exposed to several different chemical forms of indium; however, their lung dosimetry is not fully understood. We characterized …
View article: Evaluation of the effect of valence state on cerium oxide nanoparticle toxicity following intratracheal instillation in rats
Evaluation of the effect of valence state on cerium oxide nanoparticle toxicity following intratracheal instillation in rats Open
Cerium (Ce) is becoming a popular metal for use in electrochemical applications. When in the form of cerium oxide (CeO2), Ce can exist in both 3 + and 4 + valence states, acting as an ideal catalyst. Previous in vitro and in vivo evidence …