Melissa C. Leeolou
YOU?
Author Swipe
View article: Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis
Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis Open
In response to injury, a variety of different cells are recruited to sites of injury to facilitate healing. Recent studies have examined the importance of the heterogeneity of tissue resident fibroblasts and mechanical signalling pathways …
View article: A rapidly-growing friable nodule on the cheek
A rapidly-growing friable nodule on the cheek Open
Atypical fibroxanthoma and pleomorphic dermal sarcoma are on a spectrum of cutaneous tumors that present as ulcerated lesions in older adults. We present an 84-year-old man with pleomorphic dermal sarcoma, initially presenting as a bleedin…
View article: Livedoid vasculopathy
Livedoid vasculopathy Open
Livedoid vasculopathy is a painful thrombo-occlusive vascular disorder characterized by spontaneous thrombosis in medium-size arterioles, which causes localized hypoxia and skin ulceration. As livedoid vasculopathy is rare, case reports ar…
View article: Nitric oxide-releasing gel accelerates healing in a diabetic murine splinted excisional wound model
Nitric oxide-releasing gel accelerates healing in a diabetic murine splinted excisional wound model Open
Introduction According to the American Diabetes Association (ADA), 9–12 million patients suffer from chronic ulceration each year, costing the healthcare system over USD $25 billion annually. There is a significant unmet need for new and e…
View article: Bullous impetigo on a young man's abdomen
Bullous impetigo on a young man's abdomen Open
Bullous impetigo is a variant of epidermal infection by Staphylococcus aureus, representing 30% of impetigo cases. Its clinical appearance may mimic certain autoimmune blistering dermatoses and other cutaneous infections, sometimes necessi…
View article: Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoproliferative disorder in a young woman
Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoproliferative disorder in a young woman Open
Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (CD4+PCSM-LPD) is a low-grade cutaneous T cell disorder. There is no standardized approach to treatment of CD4+ PCSM-LPD due to its rarity. Herein, we discuss a 33-yea…
View article: Pullulan-Collagen Hydrogel Wound Dressing Promotes Dermal Remodeling and Wound Healing Compared to Commercially Available Collagen Dressings
Pullulan-Collagen Hydrogel Wound Dressing Promotes Dermal Remodeling and Wound Healing Compared to Commercially Available Collagen Dressings Open
PURPOSE: Developing new therapies to promote wound healing and mitigate scarring has the potential to significantly impact patient morbidity, particularly for those who suffer from chronic non-healing wounds and burns. The primary objectiv…
View article: Nitric Oxide Releasing Gel Increases Expression of Fibronectin, TGF-β1, and Accelerates Wound Healing in Diabetic Mice
Nitric Oxide Releasing Gel Increases Expression of Fibronectin, TGF-β1, and Accelerates Wound Healing in Diabetic Mice Open
PURPOSE: According to the American Diabetes Association (ADA), over 9-12 million patients suffer from chronic ulceration each year which costs the healthcare system over 25 billion annually. There is a significant unmet need for new and ef…
View article: Pathologic Mechanical Signaling Mediated by Rac2 Promotes the Foreign Body Response to Biomedical Implants
Pathologic Mechanical Signaling Mediated by Rac2 Promotes the Foreign Body Response to Biomedical Implants Open
PURPOSE: An estimated $170 billion is spent annually on biomedical devices including breast implants, pacemakers, neurostimulators and orthopedic prostheses around the world. However, between 10% and 30% of these devices fail prematurely. …
View article: QS40. Characterization of Mechanoresponsive Inflammatory Cells During Wound Healing
QS40. Characterization of Mechanoresponsive Inflammatory Cells During Wound Healing Open
Purpose: Repair after tissue injury involves a dynamic interplay among not just tissue resident cells (e.g., fibroblasts), but also cells recruited from the circulation. Myeloid cells, such as monocytes and macrophages, are derived from he…
View article: QS4. Rac2 Signaling Mediates Pathologic Foreign Body Response to Implanted Devices
QS4. Rac2 Signaling Mediates Pathologic Foreign Body Response to Implanted Devices Open
Purpose: Implanted medical devices, including breast implants, pacemakers, neurostimulators, and orthopedic protheses, are associated with more than $100 billion in annual global health care expenditures. However, between 10% and 30% of th…
View article: <scp>Pullulan‐Collagen</scp> hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
<span>Pullulan‐Collagen</span> hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings Open
Biological scaffolds such as hydrogels provide an ideal, physio‐mimetic of native extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury. While most studies have focused on the benefits of hydrogels in ac…
View article: P23. PATHOLOGIC MECHANICAL SIGNALING PROMOTES THE FOREIGN BODY RESPONSE TO BIOMEDICAL IMPLANTS
P23. PATHOLOGIC MECHANICAL SIGNALING PROMOTES THE FOREIGN BODY RESPONSE TO BIOMEDICAL IMPLANTS Open
PURPOSE: The aim of this study was to further elucidate the molecular mechanisms that mediate pathologic foreign body response (FBR) to biomedical implants. The longevity of biomedical implants is limited by the foreign body response (FBR)…
View article: Reinforced Biologic Mesh Reduces Postoperative Complications Compared to Biologic Mesh after Ventral Hernia Repair.
Reinforced Biologic Mesh Reduces Postoperative Complications Compared to Biologic Mesh after Ventral Hernia Repair. Open
Our data indicate that RBOR decreases abdominal complications and recurrence rates after ventral hernia repair compared with NC-PADM, C-PADM, and BADM.
View article: Reinforced Biologic Mesh Reduces Postoperative Complications Compared to Biologic Mesh after Ventral Hernia Repair
Reinforced Biologic Mesh Reduces Postoperative Complications Compared to Biologic Mesh after Ventral Hernia Repair Open
Background: The use of biologic mesh to reinforce the abdominal wall in ventral hernia repair has been proposed as a viable alternative to synthetic mesh, particularly for high-risk patients and in contaminated settings. However, a compari…
View article: Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration
Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration Open
Chronic non-healing wounds represent a major source of morbidity for patients and a significant economic burden. Current wound care treatments are generally passive and are unable to adapt to changes in the wound environment in real time. …
View article: A rare case of Wohlfahrtiimonas chitiniclastica infection in California
A rare case of Wohlfahrtiimonas chitiniclastica infection in California Open
We report a case of Wohlfahrtiimonas chitiniclastica in the setting of neck, upper portion of the back, and right shoulder wounds with maggot infestation. W chitiniclastica is a gram-negative, aerobic, and nonmotile rod with strong chitina…