Melissa E. Munroe
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View article: Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment
Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment Open
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of h…
View article: Noninvasive Biomarkers in Eosinophilic Esophagitis: Current Perspectives
Noninvasive Biomarkers in Eosinophilic Esophagitis: Current Perspectives Open
Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, diagnosed based on clinical symptoms and elevated eosinophil counts in esophageal mucosal biopsies. While endoscopic biopsy remains the gold standard for diagnosin…
View article: Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity
Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity Open
Objectives Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Significant morbidity and early mortality necessitate early intervention. This study harnessed SLE-associated immune dysregulation to create a Lupus Classificat…
View article: EXPEDITING LUPUS CLASSIFICATION OF AT-RISK INDIVIDUALS USING NOVEL TECHNOLOGY: OUTCOMES OF A PILOT STUDY
EXPEDITING LUPUS CLASSIFICATION OF AT-RISK INDIVIDUALS USING NOVEL TECHNOLOGY: OUTCOMES OF A PILOT STUDY Open
PV217 / #472 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose Individuals at risk of developing systemic lupus erythematosus (SLE) often go through a difficult diagnostic journey and may receive conflicting…
View article: COMPLEMENTARY LUPUS-SPECIFIC INDEXES INFORMED BY SELECT IMMUNE MEDIATORS CHARACTERIZE RISK OF CONCURRENT DISEASE ACTIVITY AND FUTURE IMPENDING FLARE IN SYSTEMIC LUPUS ERYTHEMATOSUS
COMPLEMENTARY LUPUS-SPECIFIC INDEXES INFORMED BY SELECT IMMUNE MEDIATORS CHARACTERIZE RISK OF CONCURRENT DISEASE ACTIVITY AND FUTURE IMPENDING FLARE IN SYSTEMIC LUPUS ERYTHEMATOSUS Open
PT002 / #417 Topic: AS09 - Emerging Approaches in SLE Management POSTER TOUR 01: CLINICAL OUTCOMES IN SLE 22-05-2025 10:00 AM - 10:40 AM Background/Purpose Systemic lupus erythematosus (SLE) is driven by immune dysregulation, with increase…
View article: Impact of a digital platform and flare risk blood biomarker index on lupus: A study protocol design for evaluating self efficacy and disease management
Impact of a digital platform and flare risk blood biomarker index on lupus: A study protocol design for evaluating self efficacy and disease management Open
We report the design of a pilot study employing clinic visits and a synergized digital, health coaching, and biomarker platform (aiSLE® MGMT [Management]) aimed at improving patient self-efficacy and patient-physician interactions to mitig…
View article: Tracking of Systemic Lupus Erythematosus (SLE) Longitudinally Using Biosensor and Patient-Reported Data: A Report on the Fully Decentralized Mobile Study to Measure and Predict Lupus Disease Activity Using Digital Signals—The OASIS Study
Tracking of Systemic Lupus Erythematosus (SLE) Longitudinally Using Biosensor and Patient-Reported Data: A Report on the Fully Decentralized Mobile Study to Measure and Predict Lupus Disease Activity Using Digital Signals—The OASIS Study Open
(1) Objective: Systemic lupus erythematosus (SLE) is a complex disease involving immune dysregulation, episodic flares, and poor quality of life (QOL). For a decentralized digital study of SLE patients, machine learning was used to assess …
View article: Gram-Positive Bacteria Cell Wall Peptidoglycan Polymers Activate Human Dendritic Cells to Produce IL-23 and IL-1β and Promote TH17 Cell Differentiation
Gram-Positive Bacteria Cell Wall Peptidoglycan Polymers Activate Human Dendritic Cells to Produce IL-23 and IL-1β and Promote TH17 Cell Differentiation Open
Gram-positive bacterial infections are a major cause of organ failure and mortality in sepsis. Cell wall peptidoglycan (PGN) is shed during bacterial replication, and Bacillus anthracis PGN promotes a sepsis-like pathology in baboons. Here…
View article: A Flare Risk Index Informed by Select Immune Mediators in Systemic Lupus Erythematosus
A Flare Risk Index Informed by Select Immune Mediators in Systemic Lupus Erythematosus Open
Objective Systemic lupus erythematosus (SLE) is marked by immune dysregulation linked to varied clinical disease activity. Using a unique longitudinal cohort of SLE patients, this study sought to identify optimal immune mediators informing…
View article: Pre-Clinical Autoimmunity in Lupus Relatives: Self-Reported Questionnaires and Immune Dysregulation Distinguish Relatives Who Develop Incomplete or Classified Lupus From Clinically Unaffected Relatives and Unaffected, Unrelated Individuals
Pre-Clinical Autoimmunity in Lupus Relatives: Self-Reported Questionnaires and Immune Dysregulation Distinguish Relatives Who Develop Incomplete or Classified Lupus From Clinically Unaffected Relatives and Unaffected, Unrelated Individuals Open
Systemic lupus erythematosus (SLE) is propelled by pathogenic autoantibody (AutoAb) and immune pathway dysregulation. Identifying populations at risk of reaching classified SLE is essential to curtail inflammatory damage. Lupus blood relat…
View article: Clinical disease activity and flare in SLE: Current concepts and novel biomarkers
Clinical disease activity and flare in SLE: Current concepts and novel biomarkers Open
Systemic lupus erythematosus (SLE) is a complex and heterogeneous systemic autoimmune disease associated with innate and adaptive immune dysregulation. SLE occurs primarily in females of childbearing age, with increased prevalence and seve…
View article: Epstein-Barr Functional Mimicry: Pathogenicity of Oncogenic Latent Membrane Protein-1 in Systemic Lupus Erythematosus and Autoimmunity
Epstein-Barr Functional Mimicry: Pathogenicity of Oncogenic Latent Membrane Protein-1 in Systemic Lupus Erythematosus and Autoimmunity Open
Systemic lupus erythematosus (SLE) and other autoimmune diseases are propelled by immune dysregulation and pathogenic, disease-specific autoantibodies. Autoimmunity against the lupus autoantigen Sm is associated with cross-reactivity to Ep…
View article: Associations Between Smoking and Systemic Lupus Erythematosus–Related Cytokines and Chemokines Among US Female Nurses
Associations Between Smoking and Systemic Lupus Erythematosus–Related Cytokines and Chemokines Among US Female Nurses Open
Objective Smoking has been associated with increased systemic lupus erythematosus (SLE) risk, but the biologic basis for this association is unknown. Our objective was to investigate whether women’s smoking was positively associated with S…
View article: Associations between daily alcohol consumption and systemic lupus erythematosus-related cytokines and chemokines among US female nurses without SLE
Associations between daily alcohol consumption and systemic lupus erythematosus-related cytokines and chemokines among US female nurses without SLE Open
Objectives Moderate alcohol consumption has been associated with decreased systemic lupus erythematosus risk, but the biologic basis for this association is unknown. We aimed to determine whether moderate alcohol consumption was associated…
View article: Unique Sjögren’s syndrome patient subsets defined by molecular features
Unique Sjögren’s syndrome patient subsets defined by molecular features Open
Objective To address heterogeneity complicating primary SS (pSS) clinical trials, research and care by characterizing and clustering patients by their molecular phenotypes. Methods pSS patients met American–European Consensus Group classif…
View article: 233 Autoantibody-positive healthy individuals constrain T cell pathways to regulate autoimmune disease
233 Autoantibody-positive healthy individuals constrain T cell pathways to regulate autoimmune disease Open
Background Anti-nuclear antibody (ANA) positivity is a principal feature of individuals with an autoimmune disease, yet up to one in five healthy individuals are ANA-positive (ANA+) and will never develop overt disease. Understanding diffe…
View article: Screening characteristics for enrichment of individuals at higher risk for transitioning to classified SLE
Screening characteristics for enrichment of individuals at higher risk for transitioning to classified SLE Open
Objective Further prospective study is needed to elucidate the etiology and natural history of systemic lupus erythematosus development. The clinical complexity of this heterogeneous disease makes study design challenging. Our objective wa…
View article: Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus
Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus Open
Background The role of sleep in the etiology of systemic lupus erythematosus (SLE) has not been well studied. We examined whether sleep duration was associated with subsequent transitioning to SLE in individuals at risk for SLE. Methods Fo…
View article: Unique clinical characteristics, autoantibodies and medication use in Native American patients with systemic lupus erythematosus
Unique clinical characteristics, autoantibodies and medication use in Native American patients with systemic lupus erythematosus Open
Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with varied morbidity and mortality. We assessed clinical presentations, autoantibody specificities and therapeutic interventions in Native American (NA) patient…
View article: Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis
Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis Open
Antiviral defenses are inappropriately activated in systemic lupus erythematosus (SLE) and association between SLE and the antiviral helicase gene, IFIH1, is well established. We sought to extend the previously reported association of path…
View article: Clinical and Serologic Features in Patients With Incomplete Lupus Classification Versus Systemic Lupus Erythematosus Patients and Controls
Clinical and Serologic Features in Patients With Incomplete Lupus Classification Versus Systemic Lupus Erythematosus Patients and Controls Open
Objective Incomplete lupus erythematosus (ILE) involves clinical and/or serologic manifestations consistent with but insufficient for systemic lupus erythematosus (SLE) classification. Because the nature of ILE is poorly understood and no …
View article: Systemic lupus erythematosus biomarkers: the challenging quest
Systemic lupus erythematosus biomarkers: the challenging quest Open
SLE, a multisystem heterogeneous disease, is characterized by production of antibodies to cellular components, with activation of both the innate and the adaptive immune system. Decades of investigation of blood biomarkers has resulted in …
View article: Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features
Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features Open
Objective Systemic lupus erythematosus (SLE) and other autoimmune diseases cause significant morbidity. Identifying populations at risk of developing SLE is essential for curtailing irreversible inflammatory damage. The aim of this study w…
View article: Impact of heart rate variability, a marker for cardiac health, on lupus disease activity
Impact of heart rate variability, a marker for cardiac health, on lupus disease activity Open
Impaired HRV, particularly the LF/HF ratio, is associated with lupus disease activity and several cytokines related to IFN type II and TNF pathways. The strongest association was with MIG and sTNFRII, expanding previous immune connections …