Melissa Gresle
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View article: CS12 Exploration of an objective measure of cognitive fatigability in multiple sclerosis using the MSReactor digital platform
CS12 Exploration of an objective measure of cognitive fatigability in multiple sclerosis using the MSReactor digital platform Open
View article: C4 genetic structural variations affect multiple sclerosis risk and progression
C4 genetic structural variations affect multiple sclerosis risk and progression Open
Objective Major histocompatibility complex (MHC) locus carries a significant genetic risk burden for multiple sclerosis (MS). Here we investigate the structurally diverse complement component 4 ( C4 ) alleles within the MHC in MS developme…
View article: Long-term acceptability of MSReactor digital cognitive monitoring among people living with multiple sclerosis
Long-term acceptability of MSReactor digital cognitive monitoring among people living with multiple sclerosis Open
Background: Monitoring of cognition in multiple sclerosis (MS) is critical. Traditional cognitive testing is resource intensive and insensitive to subtle changes. Digital tests could address this need; however, their long-term usability re…
View article: Longitudinal Trajectories of Digital Cognitive Biomarkers for Multiple Sclerosis
Longitudinal Trajectories of Digital Cognitive Biomarkers for Multiple Sclerosis Open
Background Cognitive impairment is one of the most common and debilitating symptoms of relapsing–remitting multiple sclerosis (RRMS). Digital cognitive biomarkers require less time and resources and are rapidly gaining popularity in clinic…
View article: Adaptive transformer modelling of density function for nonparametric survival analysis
Adaptive transformer modelling of density function for nonparametric survival analysis Open
Survival analysis holds a crucial role across diverse disciplines, such as economics, engineering and healthcare. It empowers researchers to analyze both time-invariant and time-varying data, encompassing phenomena like customer churn, mat…
View article: Longitudinal trajectories of digital upper limb biomarkers for multiple sclerosis
Longitudinal trajectories of digital upper limb biomarkers for multiple sclerosis Open
Background Upper limb dysfunction is a common debilitating feature of relapsing‐remitting multiple sclerosis (RRMS). We aimed to examine the longitudinal trajectory of the iPad®‐based Manual Dexterity Test (MDT) and predictors of change ov…
View article: Adaptive Transformer Modelling of Density Function for Nonparametric Survival Analysis
Adaptive Transformer Modelling of Density Function for Nonparametric Survival Analysis Open
Survival analysis holds a crucial role across diverse disciplines, such as economics, engineering and healthcare. It empowers researchers to analyze both time-invariant and time-varying data, encompassing phenomena like customer churn, mat…
View article: Transcriptional network analysis of peripheral blood leukocyte subsets in multiple sclerosis identifies a pathogenic role for a cytotoxicity‐associated gene network in myeloid cells
Transcriptional network analysis of peripheral blood leukocyte subsets in multiple sclerosis identifies a pathogenic role for a cytotoxicity‐associated gene network in myeloid cells Open
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system affecting predominantly adults. It is a complex disease associated with both environmental and genetic risk factors. Although over 230 risk single‐nucleotide po…
View article: The immune cell transcriptome is modulated by vitamin D3 supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial
The immune cell transcriptome is modulated by vitamin D3 supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial Open
Vitamin D deficiency is a risk factor for developing multiple sclerosis. The PrevANZ trial was conducted to determine if vitamin D3 supplementation can prevent recurrent disease activity in people with a first demyelinating even…
View article: Transcriptomics identifies blunted immunomodulatory effects of vitamin D in people with multiple sclerosis
Transcriptomics identifies blunted immunomodulatory effects of vitamin D in people with multiple sclerosis Open
View article: The impact of COVID-19 infection on multiple sclerosis disease course across 12 countries: a propensity-score-matched cohort study
The impact of COVID-19 infection on multiple sclerosis disease course across 12 countries: a propensity-score-matched cohort study Open
Background: The relationship between coronavirus disease 2019 (COVID-19) infection and multiple sclerosis (MS) relapse and disease progression remains unclear. Previous studies are limited by small sample sizes and most lack a propensity-m…
View article: The Patient‐Determined Disease Steps scale is not interchangeable with the Expanded Disease Status Scale in mild to moderate multiple sclerosis
The Patient‐Determined Disease Steps scale is not interchangeable with the Expanded Disease Status Scale in mild to moderate multiple sclerosis Open
Background and purpose The validity, reliability, and longitudinal performance of the Patient‐Determined Disease Steps (PDDS) scale is unknown in people with multiple sclerosis (MS) with mild to moderate disability. We aimed to examine the…
View article: 1 Patient-determined disease steps is not equivalent to the expanded disability status scale in mild to moderate multiple sclerosis
1 Patient-determined disease steps is not equivalent to the expanded disability status scale in mild to moderate multiple sclerosis Open
Background Patient Determined Disease Steps(PDDS) is a common patient-reported outcome(PRO) in multiple sclerosis(MS). However, concerns remain over its validity and reliability in mild to moderate disability, longitudinal performance and …
View article: Smartphone monitoring of cognition in people with multiple sclerosis: A systematic review
Smartphone monitoring of cognition in people with multiple sclerosis: A systematic review Open
Smartphone applications are reliable and valid biomarkers of real-world cognition in pwMS. Further longitudinal data would allow for a better understanding of their predictive and ecological validity.
View article: 011 Worsening longitudinal reaction time trajectories using the MSReactor computerised battery predicts confirmed EDSS progression
011 Worsening longitudinal reaction time trajectories using the MSReactor computerised battery predicts confirmed EDSS progression Open
Objectives To identify and validate longitudinal reaction time trajectories in relapsing remitting multiple sclerosis using a computerised cognitive battery and latent class mixed modelling, and to assess the association between reaction t…
View article: 004 Pregnancy-related relapse in natalizumab, fingolimod and dimethyl fumarate-treated women with multiple sclerosis
004 Pregnancy-related relapse in natalizumab, fingolimod and dimethyl fumarate-treated women with multiple sclerosis Open
Objective To investigate pregnancy-related disease activity in a contemporary multiple sclerosis (MS) cohort. Methods Data were obtained from the MSBase Registry. Term/preterm pregnancies conceived from 2011-2019 were included (modern coho…
View article: Natalizumab, Fingolimod, and Dimethyl Fumarate Use and Pregnancy-Related Relapse and Disability in Women With Multiple Sclerosis
Natalizumab, Fingolimod, and Dimethyl Fumarate Use and Pregnancy-Related Relapse and Disability in Women With Multiple Sclerosis Open
Objective: To investigate pregnancy-related disease activity in a contemporary multiple sclerosis (MS) cohort. Methods: Using data from the MSBase Registry, we included pregnancies conceived after 31 Dec 2010 from women with relapsing-remi…
View article: Epigenetic differences at the HTR2A locus in progressive multiple sclerosis patients
Epigenetic differences at the HTR2A locus in progressive multiple sclerosis patients Open
View article: Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis
Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis Open
Initially recognised as an important factor for bone health, vitamin D is now known to have a range of effects on the immune system. Vitamin D deficiency is associated with an increased risk of multiple sclerosis (MS), a chronic immune‐med…
View article: Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells Open
At least 200 single-nucleotide polymorphisms (SNPs) are associated with multiple sclerosis (MS) risk. A key function that could mediate SNP-encoded MS risk is their regulatory effects on gene expression. We performed microarrays using RNA …
View article: Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis
Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis Open
The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying t…
View article: Monoclonal antibodies in the treatment of multiple sclerosis: emergence of B‐cell‐targeted therapies
Monoclonal antibodies in the treatment of multiple sclerosis: emergence of B‐cell‐targeted therapies Open
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS, and one of the most common causes of disability in young adults. Over the last decade, new disease‐modifying therapies have emerged, including monoclonal antibodies (mAb…
View article: Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status
Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status Open
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk of developing MS is strongly influenced by genetic predisposition, and over 100 loci have been established as associated with s…
View article: Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve
Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve Open
Background Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of expe…
View article: Association of plasma levels of Protein S with disease severity in multiple sclerosis
Association of plasma levels of Protein S with disease severity in multiple sclerosis Open
Background The TAM family of receptor tyrosine kinases (TYRO3, AXL and MERTK) play important roles in modulating innate immune responses and central demyelination. The TAM receptor ligand Protein S (PROS) has also been shown to modulate in…
View article: A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis
A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis Open
Multiple sclerosis (MS) is a chronic relapsing-remitting inflammatory disease of the central nervous system characterized by oligodendrocyte damage, demyelination and neuronal death. Genetic association studies have shown a 2-fold or great…
View article: The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function
The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function Open
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development of multiple sclerosis (MS). We investigated the cell specific gene and protein expression variation controlled by the CD40 genetic variant(…
View article: Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor
Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor Open
In order to further investigate the molecular mechanisms that regulate oligodendrocyte (OC) survival, we utilized microarrays to characterize changes in OC gene expression after exposure to the cytokines neurotrophin3, insulin, or leukemia…