Explanipedia

Derivation of Pulse Wave Velocity from Arterial Waveforms in Children Open

John M. Dagle, Mendi L. Schmelzel, Karen Johnson, Michael H. Tomasson, Madhuradhar Chegondi , et al. · 2025

Aortic stiffness can be measured using aortic pulse wave velocity (PWV), calculated from peripheral arterial waveforms. However, this method has not been validated in children. We sought to determine whether PWV could be feasibly measured …

Vitamin B6 (Pyridoxal 5′ Phosphate) antagonises carotid body P2X3 receptors in hypertension Open

Igor Felippe, Thalia Babbage, Riyadh Shaheen, Marcella Bassetto, Jui‐Lin Fan , et al. · 2025

Aims ATP acting on P2X3 receptors (P2X3R) within carotid bodies (CBs) underpins chemoreflex-mediated sympathetic overactivity in spontaneously hypertensive rats (SHR). Pyridoxal 5′ phosphate (PLP), the active form of vitamin B6, has been r…

Cancer and Post‐Therapy Cardiotoxicity Risk in Adolescents, Young Adults, and Adults With Down Syndrome Open

Michelle Buckman, Anastasiia Vasileva, Charles Jedlicka, Hardik Kalra, Mikhail Vasilyev , et al. · 2025

The median life expectancy of people with Down syndrome has increased substantially over the past several decades, from 4 years in 1970 to 53 years in 2010. Despite the recent improvement in survival, there is little data about the prevale…

Spontaneous peripheral oxygen desaturation and apnea events in mice vary by strain and inspired oxygen level Open

Hardik Kalra, Anastasiia Vasileva, Charles Jedlicka, Mikhail Vasilyev, Michelle Buckman , et al. · 2025

Mouse models of chronic intermittent hypoxia are widely used in research to understand the role of sleep apnea in disease pathogenesis. Mice exposed to periodic reductions in F I O 2 model arterial desaturations observed in humans and reca…

Cancer and Post-therapy Cardiotoxicity Risk in Adolescents, Young Adults, and Adults with Down Syndrome Open

Michelle Buckman, Anastasiia Vasileva, Charles Jedlicka, Mikhail Vasilyev, Hardik Kalra , et al. · 2025

The median life expectancy of people with Down syndrome has increased substantially over the past several decades, from 4 years in 1970 to 53 years in 2010. Despite the recent improvement in survival, there is little data about the prevale…

Cardiovascular function and autonomic regulation in urethane-anesthetized and conscious mice Open

Anastasiia Vasileva, Laura Flores, Mikhail Vasilyev, Michelle Buckman, Lara R. DeRuisseau , et al. · 2024

This investigation documents cardiovascular outcomes in mice receiving urethane anesthesia, emphasizing sex as a biological variable, and considering oxygen supplementation during anesthesia. This is the first report of M-curve analysis in…

eLife Assessment: Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia Open

Melissa L. Bates · 2024

eLife Assessment: Chemogenetic stimulation of phrenic motor output and diaphragm activity Open

Melissa L. Bates · 2024

Impaired diaphragm activation contributes to morbidity and mortality in many neurodegenerative diseases and neurologic injuries. We conducted experiments to determine if expression of an excitatory DREADD (designer receptors exclusively ac…

Elevating professional well-being in healthcare Open

William H. Carson, Melissa L. Bates, John Howard · 2024

A crosswalk of the NIOSH Impact Wellbeing™ campaign and the ANCC Pathway to Excellence ® Framework

Consequences of Preterm Birth: Knowns, Unknowns, and Barriers to Advancing Cardiopulmonary Health Open

Colin D. Hubbard, Melissa L. Bates, Andrew T. Lovering, Joseph W. Duke · 2023

Synopsis Preterm birth occurs in 10% of all live births and creates challenges to neonatal life, which persist into adulthood. Significant previous work has been undertaken to characterize and understand the respiratory and cardiovascular …

A statistical analysis of the structure of the interstellar medium in the disc of the Milky Way Open

Melissa L. Bates, A. P. Whitworth · 2023

We construct Convolutional Neural Networks (CNNs) trained on exponentiated fractional Brownian motion (xfBm) images, and use these CNNs to analyse Hi-GAL images of surface density in the Galactic Plane. The CNNs estimate the Hurst paramete…

Importance of survey demographic questions to foster inclusion in medicine and research and reduce health inequities for LGBTQIA2S+ individuals Open

Jesse D. Moreira, Karla Haack, Vee White, Melissa L. Bates, Deepa M. Gopal , et al. · 2023

A clear, inclusive, and accurate approach to the collection of demographic information in clinical research and medical practice is critical to understanding the healthcare needs of the specific population. Inclusive demography constitutes…

CORP: Sources and degrees of variability in whole animal intermittent hypoxia experiments Open

Zishan Zhang, Hardik Kalra, Matthew Delzell, Charles Jedlicka, Mikhail Vasilyev , et al. · 2023

Intermittent hypoxia exposures are commonly used in physiology and many investigators use chamber systems to perform these studies. Because of the variety of chamber systems and protocols used, it is important to understand the sources of …

Sex differences in cardiovascular disease and dysregulation in Down syndrome Open

Melissa L. Bates, Anastasiia Vasileva, Laura D. M. Flores, Yana Pryakhina, Michelle Buckman , et al. · 2023

In patients with Down syndrome (DS), CHD is the leading cause of death 20 yr old. Men with DS live longer than women. It is unknown if sex differences are present in cardiovascular disease and dysregulation in DS across the lifespan. We ob…

Management of two circulations in a <span>COVID</span>‐19 patient with secondary superinfection Open

RACHAEL M STADLEN, Arun Singhal, Robert M. Reed, Jeffrey D. Hasday, Melissa L. Bates , et al. · 2023

Optimal oxygenation in the intensive care unit requires adequate pulmonary gas exchange, oxygen‐carrying capacity in the form of hemoglobin, sufficient delivery of oxygenated hemoglobin to the tissue, and an appropriate tissue oxygen deman…

Breathing and Oxygen Carrying Capacity in Ts65Dn and Down Syndrome Open

Lara R. DeRuisseau, Candace N. Receno, Caitlin Cunningham, Melissa L. Bates, Morgan Goodell , et al. · 2023

Individuals with Down syndrome (Ds) are at increased risk of respiratory infection, aspiration pneumonia, and apnea. The Ts65Dn mouse is a commonly used model of Ds, but there have been no formal investigations of awake breathing and respi…

CORP: Sources and degrees of variability in whole animal intermittent hypoxia experiments Open

Zishan Zhang, Hardik Kalra, Matthew Delzell, Charles Jedlicka, Anastasiia Vasileva , et al. · 2023

Statitics of the manuscript.

Utilizing digital pathology and immunohistochemistry of p53 as an adjunct to molecular testing in myeloid disorders Open

Kai J. Rogers, Ibrahim M. Abukhiran, Sergei Syrbu, Michael H. Tomasson, Melissa L. Bates , et al. · 2023

The Stand Open

Melissa L. Bates · 2022

Editor's evaluation: Gasotransmitter modulation of hypoglossal motoneuron activity Open

Melissa L. Bates · 2022

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Obstructive sleep apnea (OSA) is cha…

Challenges and inclusive practices for LGBTQIA2S+ scientists in the American Physiological Society Open

Jesse D. Moreira, Melissa L. Bates, Troy A. Roepke · 2022

The use of simulated research rehearsals to address barriers to cardiopulmonary physiology research in the neonatal intensive care unit Open

Ramya Deepthi Billa, Dara Byrne, Christopher Richard Barnard, Mendi L. Schmelzel, Emily Spellman , et al. · 2021

Background: Studying the physiology of the extremely premature neonate is critical to understanding the lifelong impact of prematurity, yet there are many barriers to physiologic research in the NICU. We describe the use of simulated resea…

Editor's evaluation: An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents Open

Melissa L. Bates · 2021

Case Studies in Physiology: Untangling the cause of hypoxemia in a patient with obesity with acute leukemia Open

Iliya Amaza, Hardik Kalra, Michael Eberlein, Yogesh Jethava, Joseph McDonell , et al. · 2021

Discerning the cause of dyspnea and hypoxemia in complex patients can be difficult. We describe the “real world” application of an innovative methodology to untangle the underlying physiology in a patient with multiple comorbidities. This …

Table of Contents Open

Melissa L. Bates, Philip T. Levy, Anne Monique Nuyt, Kara N. Goss, Adam J. Lewandowski , et al. · 2020

Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk Open

Adam J. Lewandowski, Philip T. Levy, Melissa L. Bates, Patrick J. McNamara, Anne Monique Nuyt , et al. · 2020

Preterm birth accounts for over 15 million global births per year. Perinatal interventions introduced since the early 1980s, such as antenatal glucocorticoids, surfactant, and invasive ventilation strategies, have dramatically improved sur…

Everyone must be able to breathe: a plan to support diversity and inclusion in respiratory physiology Open

Melissa L. Bates, Karla K. V. Haack · 2020

As a scientist, I (M.L.B.) have spent the past 20 years thinking about how we breathe as a basic physiological process.Now, I feel overwhelming grief when I hear "I can't breathe" as a refrain from our fellow black Americans.The topic that…

Increased aortic stiffness and elevated blood pressure in response to exercise in adult survivors of prematurity Open

Christopher Richard Barnard, Matthew E. Peters, Amy L. Sindler, Emily T. Farrell, Kim R. Baker , et al. · 2020

In this first report of the blood pressure response to exercise in adults born prematurely, we found exercise-induced hypertension relative to a term-born control group that is associated with increased large artery stiffness. These experi…

The snoRNA target of t(4;14) in multiple myeloma regulates ribosome biogenesis Open

Vanessa De Oliveira, Nitin Mahajan, Melissa L. Bates, Chakrapani Tripathi, Kyusik Q. Kim , et al. · 2019

The orphan small nucleolar RNA (snoRNA) ACA11 is overexpressed as a result of the t(4;14) chromosomal translocation in multiple myeloma (MM), increases reactive oxygen species, and drives cell proliferation. Like other snoRNAs, ACA11 is pr…

Chronic intermittent hypoxia enhances disease progression in myeloma-resistant mice Open

Mahmoud Ali, Sandeep Kowkuntla, Derick Delloro, Csaba Galambos, Deep Hathi , et al. · 2019

Obesity is the only known modifiable risk factor for multiple myeloma (MM), an incurable cancer of bone marrow plasma cells. The mechanism linking the two is unknown. Obesity is associated with an increased risk of sleep apnea, which resul…

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