Melissa Pergakis
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View article: Predicting 24-Hour Blood Pressure Variability Post Thrombectomy Using Machine Learning for Patients with Ischemic Stroke from Anterior Circulation Large Vessel Occlusion
Predicting 24-Hour Blood Pressure Variability Post Thrombectomy Using Machine Learning for Patients with Ischemic Stroke from Anterior Circulation Large Vessel Occlusion Open
This study identified the interval from last-known-well time-to-groin puncture, age, and NIHSS as factors significantly associated with increased 24-hour BPV in random forest analysis. These predisposing factors in our machine learning ana…
View article: A Hybrid Simulation‐Based Workshop Improves Knowledge and Confidence in the Management of Hemorrhagic Conversion of Stroke Among Interventional Neurology Trainees
A Hybrid Simulation‐Based Workshop Improves Knowledge and Confidence in the Management of Hemorrhagic Conversion of Stroke Among Interventional Neurology Trainees Open
Background Mechanical thrombectomy is the standard of care in acute ischemic stroke with anterior large vessel occlusion presenting within 6 hours of symptom onset, but complications do exist. We assessed the feasibility of a hybrid simula…
View article: Behavioral Assessment With the Coma Recovery Scale—Revised Is Safe and Feasible in Critically Ill Patients With Disorders of Consciousness
Behavioral Assessment With the Coma Recovery Scale—Revised Is Safe and Feasible in Critically Ill Patients With Disorders of Consciousness Open
OBJECTIVES: Accurate classification of disorders of consciousness (DoC) is key in developing rehabilitation plans after brain injury. The Coma Recovery Scale—Revised (CRS-R) is a sensitive measure of consciousness validated in the rehabili…
View article: A hybrid simulation-based workshop improves knowledge and confidence in the management of hemorrhagic conversion of stroke among interventional neurology trainees
A hybrid simulation-based workshop improves knowledge and confidence in the management of hemorrhagic conversion of stroke among interventional neurology trainees Open
Objectives To assess the feasibility of a hybrid simulation-based workshop at a national meeting for interventional neurology trainees focused on the management of acute ischemic stroke and tissue-plasminogen activator (tPA)-related hemorr…
View article: Smartphone Use in the Management of Neurological Emergencies: A Simulation-based Study
Smartphone Use in the Management of Neurological Emergencies: A Simulation-based Study Open
Background and Objectives Smartphone use in medicine is nearly universal despite a dearth of research assessing utility in clinical performance. We sought to identify and define smartphone use during simulated neuro-emergencies. Methods In…
View article: Comparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis
Comparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis Open
Endotracheal intubation, frequently required during management of refractory status epilepticus (RSE), can be facilitated by anesthetic medications; however, their effectiveness for RSE control is unknown. We performed a single-center retr…
View article: Common Data Element for Disorders of Consciousness: Recommendations from the Working Group on Therapeutic Interventions
Common Data Element for Disorders of Consciousness: Recommendations from the Working Group on Therapeutic Interventions Open
The newly created CRF enhances systematization of future work by proposing a portfolio of measures that should be collected in the development and implementation of studies assessing novel interventions intended to increase the level of co…
View article: Iodine-based dual-energy CT predicts early neurological decline from cerebral edema after large hemispheric infarction
Iodine-based dual-energy CT predicts early neurological decline from cerebral edema after large hemispheric infarction Open
Background & Purpose: Ischemia affecting two thirds of the MCA territory predicts development of malignant cerebral edema. However, early infarcts are hard to diagnose on conventional head CT. We hypothesize that high-energy (190keV) virtu…
View article: Education Research: Junior Neurology Residents Achieve Competency but Not Mastery After a Brief Acute Ischemic Stroke Simulation Course
Education Research: Junior Neurology Residents Achieve Competency but Not Mastery After a Brief Acute Ischemic Stroke Simulation Course Open
A brief AIS simulation course may improve junior residents' performance and confidence to a level comparable with senior residents, although not to mastery.
View article: Steroids Provide Temporary Improvement of Refractory Pain Following Subarachnoid Hemorrhage
Steroids Provide Temporary Improvement of Refractory Pain Following Subarachnoid Hemorrhage Open
Introduction Evidence for optimal analgesia following subarachnoid hemorrhage (SAH) is limited. Steroid therapy for pain refractory to standard regimens is common despite lack of evidence for its efficacy. We sought to determine if steroid…
View article: 12 Comparison of induction agents for rapid sequence intubation in refractory status epilepticus
12 Comparison of induction agents for rapid sequence intubation in refractory status epilepticus Open
OBJECTIVES/GOALS: Multiple induction agents can facilitate rapid sequence intubation (RSI) in management of refractory status epilepticus (rSE), many which have anti-seizure properties. We examine the anti-seizure efficacy and safety of in…
View article: Scoping Review: Innovations in Clinical Neurology Education
Scoping Review: Innovations in Clinical Neurology Education Open
Advances in adult learning theory and instructional technologies provide opportunities to improve neurology knowledge acquisition. This scoping review aimed to survey the emerging landscape of educational innovation in clinical neurology. …
View article: Education Research: High-Fidelity Simulation to Evaluate Diagnostic Reasoning Reveals Failure to Detect Viral Encephalitis in Medical Trainees
Education Research: High-Fidelity Simulation to Evaluate Diagnostic Reasoning Reveals Failure to Detect Viral Encephalitis in Medical Trainees Open
Although initial seizure treatment was sufficient, failure to recognize HSV encephalitis was common with few trainees initiating appropriate treatment potentially leading to poor outcomes in real-life scenarios. High-fidelity simulation ho…
View article: Author Response: Simulation-Based Assessment of Graduate Neurology Trainees' Performance Managing Acute Ischemic Stroke
Author Response: Simulation-Based Assessment of Graduate Neurology Trainees' Performance Managing Acute Ischemic Stroke Open
View article: Simulation-based assessment of trainee’s performance in post-cardiac arrest resuscitation
Simulation-based assessment of trainee’s performance in post-cardiac arrest resuscitation Open
View article: BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema
BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema Open
Introduction: Brain swelling due to edema formation is a major cause of neurological deterioration and death in patients with large hemispheric infarction (LHI) and severe traumatic brain injury (TBI), especially contusion-TBI. Prec…