Melissa Wassink
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View article: Data from Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity
Data from Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity Open
Sialic acid sugars on the surface of cancer cells have emerged as potent immune modulators that contribute to the immunosuppressive microenvironment and tumor immune evasion. However, the mechanisms by which these sugars modulate antitumor…
View article: Figure S1-S13 from Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity
Figure S1-S13 from Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity Open
Fig. S1 Effect of intratumoral injections with 20 mg/kg S1 Ac53FaxNeu5Ac on B16-F10WT tumor growth. Fig. S2 Responsiveness of melanoma and neuroblastoma cells to Ac53FaxNeu5Ac. S2 Fig. S3 10 mg/kg Ac53FaxNeu5Ac injections are well tolerate…
View article: Figure S1-S13 from Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity
Figure S1-S13 from Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity Open
Fig. S1 Effect of intratumoral injections with 20 mg/kg S1 Ac53FaxNeu5Ac on B16-F10WT tumor growth. Fig. S2 Responsiveness of melanoma and neuroblastoma cells to Ac53FaxNeu5Ac. S2 Fig. S3 10 mg/kg Ac53FaxNeu5Ac injections are well tolerate…
View article: Data from Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity
Data from Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity Open
Sialic acid sugars on the surface of cancer cells have emerged as potent immune modulators that contribute to the immunosuppressive microenvironment and tumor immune evasion. However, the mechanisms by which these sugars modulate antitumor…
View article: Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation
Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation Open
Introduction In situ tumor ablation releases a unique repertoire of antigens from a heterogeneous population of tumor cells. High-intensity focused ultrasound (HIFU) is a completely noninvasive ablation therapy that can be used to ablate t…
View article: Sialic acid blockade in dendritic cells enhances CD8+ T cell responses by facilitating high-avidity interactions
Sialic acid blockade in dendritic cells enhances CD8+ T cell responses by facilitating high-avidity interactions Open
View article: Correction: C reactive protein impairs adaptive immunity in immune cells of patients with melanoma
Correction: C reactive protein impairs adaptive immunity in immune cells of patients with melanoma Open
View article: Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes
Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes Open
Background Tumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendrit…
View article: Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model
Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model Open
Neuroblastoma is a childhood malignancy and in the majority of patients, the primary tumor arises in one of the adrenal glands. Neuroblastoma cells highly express the disialoganglioside GD2, which is the primary target for the development …
View article: Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2
Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2 Open
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View article: Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity
Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity Open
Sialic acid sugars on the surface of cancer cells have emerged as potent immune modulators that contribute to the immunosuppressive microenvironment and tumor immune evasion. However, the mechanisms by which these sugars modulate antitumor…
View article: SP-0014: In situ Cancer Vaccines: Tumor destruction and immune stimulation for local and systemic tumor control
SP-0014: In situ Cancer Vaccines: Tumor destruction and immune stimulation for local and systemic tumor control Open
View article: Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation Open
Saponin-based adjuvants (SBAs) are being used in animal and human (cancer) vaccines, as they induce protective cellular immunity. Their adjuvant potency is a factor of inflammasome activation and enhanced antigen cross-presentation by dend…
View article: Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma
Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma Open
Neuroblastoma (NBL) is a childhood malignancy of the sympathetic nervous system. For high-risk NBL patients, the mortality rate is still over 50%, despite intensive multimodal treatment. Anti-GD2 monoclonal antibody (mAB) in combination wi…
View article: Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals
Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals Open