Melod Mehdipour
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View article: Enhancing peripheral nerve regeneration in aging: the role of Schwann cells, c-Jun, and emerging therapeutic strategies
Enhancing peripheral nerve regeneration in aging: the role of Schwann cells, c-Jun, and emerging therapeutic strategies Open
Peripheral nerve injuries (PNI) present a significant challenge, particularly in aging populations where Schwann cell dysfunction, reduced c-Jun expression, increased senescence, and impaired myelin clearance hinder regeneration. Targeted …
View article: Unlocking nerve regeneration: electrical stimulation and bioscaffolds to enhance peripheral nerve regeneration
Unlocking nerve regeneration: electrical stimulation and bioscaffolds to enhance peripheral nerve regeneration Open
Peripheral nerve injury (PNI) is a challenging clinical problem resulting in disabling sensorimotor deficits, which may become permanent if recovery does not take place in a timely manner. In this review, we examine recent insights into ke…
View article: Ophthalmic acid is a bloodborne metabolite that contributes to age-induced cardiomyocyte hypertrophy
Ophthalmic acid is a bloodborne metabolite that contributes to age-induced cardiomyocyte hypertrophy Open
Cardiac aging involves the development of left ventricular hypertrophy alongside a decline in functional capacity. Here, we use neutral blood exchange to demonstrate that the acute removal of age-accumulated blood factors significantly reg…
View article: Mechanisms and Minimization of False Discovery of Metabolic Bioorthogonal Noncanonical Amino Acid Proteomics
Mechanisms and Minimization of False Discovery of Metabolic Bioorthogonal Noncanonical Amino Acid Proteomics Open
Metabolic proteomics has been widely used to characterize dynamic protein networks in many areas of biomedicine, including in the arena of tissue aging and rejuvenation. Bioorthogonal noncanonical amino acid tagging (BONCAT) is based on mu…
View article: Red Dye Experimental vs Theoretical Primary Data
Red Dye Experimental vs Theoretical Primary Data Open
Excel files for Figure 6 of the manuscript.
View article: Theoretical and Experimental Curve Data for Figure 7
Theoretical and Experimental Curve Data for Figure 7 Open
Theoretical and Experimental Curve Data for Figure 7
View article: Mehdipour_RedDyeExchanges_Fig6.xls
Mehdipour_RedDyeExchanges_Fig6.xls Open
Original derivations for the equations described in the manuscript corresponding to Figure 6. Primary data for Figure 6 is also attached.
View article: Mehdipour_C3_ELISA.xls
Mehdipour_C3_ELISA.xls Open
Excel files for Figure 7.
View article: Plasma dilution improves cognition and attenuates neuroinflammation in old mice
Plasma dilution improves cognition and attenuates neuroinflammation in old mice Open
Our recent study has established that young blood factors are not causal, nor necessary, for the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral blood exchange (NBE) that resets signaling milieu to a…
View article: Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin Open
Heterochronic blood sharing rejuvenates old tissues, and most of the studies on how this works focus on young plasma, its fractions, and a few youthful systemic candidates. However, it was not formally established that young blood is neces…
View article: Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age
Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age Open
We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging. Investigating this has revealed a novel approach to rejuvenate multiple mammalian tissues by defined pharmacology. Specific…
View article: Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis
Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis Open
Studies of heterochronic parabiosis demonstrated that with age, the composition of the circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In addition, local tissue niches have age-specific influences on t…
View article: A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood Open
Heterochronic parabiosis rejuvenates the performance of old tissue stem cells at some expense to the young, but whether this is through shared circulation or shared organs is unclear. Here we show that heterochronic blood exchange between …