Melody A. Swartz
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View article: Probing cellular activity via charge-sensitive quantum nanoprobes
Probing cellular activity via charge-sensitive quantum nanoprobes Open
Nitrogen-vacancy (NV) based quantum sensors hold great potential for real-time single-cell sensing with far-reaching applications in fundamental biology and medical diagnostics. Although highly sensitive, the mapping of quantum measurement…
View article: Encoding Qubits using the Anti-Stokes Peak from a Working CF/LANR Nanomaterial
Encoding Qubits using the Anti-Stokes Peak from a Working CF/LANR Nanomaterial Open
MIT researchers used two slightly different frequency lasers to manipulate nuclear spin. We somewhat copied that with CF/LANR anti-Stokes emission. With additional coherent reflection, these two close-in-frequency photons dramatically impa…
View article: Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy
Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy Open
Background The use of immune checkpoint inhibitors (CPIs) has become a dominant regimen in modern cancer therapy, however immune resistance induced by tumor-associated macrophages (TAMs) with immune suppressive and evasion properties limit…
View article: Engineering Challenges and Opportunities in Autologous Cellular Cancer Immunotherapy
Engineering Challenges and Opportunities in Autologous Cellular Cancer Immunotherapy Open
The use of a patient’s own immune or tumor cells, manipulated ex vivo, enables Ag- or patient-specific immunotherapy. Despite some clinical successes, there remain significant barriers to efficacy, broad patient population applicability, a…
View article: Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity
Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity Open
Cancer immunotherapy is moving toward combination regimens with agents of complementary mechanisms of action to achieve more frequent and robust efficacy. However, compared with single-agent therapies, combination immunotherapies are assoc…
View article: 1209 Mechanisms of post-immunotherapy efficacy enhancement by tumor lymphangiogenesis
1209 Mechanisms of post-immunotherapy efficacy enhancement by tumor lymphangiogenesis Open
Background Vascular endothelial growth factor-C (VEGF-C) expression and subsequent lymphangiogenesis in the tumor microenvironment are associated with metastasis and poor prognosis in melanoma and other solid tumors. We previously demonstr…
View article: Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
Membrane-localized neoantigens predict the efficacy of cancer immunotherapy Open
Immune checkpoint immunotherapy (ICI) can re-activate immune reactions against neoantigens, leading to remarkable remission in cancer patients. Nevertheless, only a minority of patients are responsive to ICI, and approaches for prediction …
View article: TGF-β Signaling Prevents MHC Class II–Expressing Lymphatic Endothelial Cells from Reactivating Human Allogenic Memory CD4+ T Cells
TGF-β Signaling Prevents MHC Class II–Expressing Lymphatic Endothelial Cells from Reactivating Human Allogenic Memory CD4+ T Cells Open
Lymphatic endothelial cells (LECs) express MHC class II (MHC-II) upon IFN-γ stimulation, yet recent evidence suggests that LECs cannot activate naive or memory CD4+ T cells. In this article, we show that IFN-γ–activated human dermal LECs c…
View article: Prophylactic and therapeutic use of synthetically glycosylated antigens to limit allergic airway disease
Prophylactic and therapeutic use of synthetically glycosylated antigens to limit allergic airway disease Open
Asthma is a disease involving chronic airway inflammation affecting more than 300 million people worldwide. There is currently no cure for asthma. While effective, corticosteroids cause broad immune suppression and long-term debilitating d…
View article: VEGFR-3 Stimulation on LECs Boosts Type 2 Immunity After Vaccination
VEGFR-3 Stimulation on LECs Boosts Type 2 Immunity After Vaccination Open
Lymphatic vessels are the main transport routes for fluid, antigens, exosomes, and immune cells from peripheral tissues to the lymph nodes (LNs). In addition to being pervasive through tissue, lymphatic vessels are also abundant within the…
View article: Supplementary Figures 1-12 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions
Supplementary Figures 1-12 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions Open
Supplementary Figures and Legends
View article: Supplementary Table 1 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions
Supplementary Table 1 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions Open
Supplementary Table 1
View article: Supplemental Figure Legends from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers
Supplemental Figure Legends from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers Open
Supplemental Figure Legends
View article: Data from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers
Data from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers Open
Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune re…
View article: Supplemental Figure Legends from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers
Supplemental Figure Legends from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers Open
Supplemental Figure Legends
View article: Data from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions
Data from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions Open
Several solid malignancies trigger lymphangiogenesis, facilitating metastasis. Tumor-associated lymphatic vessels significantly contribute to the generation of an immunosuppressive tumor microenvironment (TME). Here, we have investigated t…
View article: Data from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers
Data from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers Open
Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune re…
View article: Supplementary Figures from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers
Supplementary Figures from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers Open
Supplementary Figures
View article: Supplementary Figures from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers
Supplementary Figures from Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers Open
Supplementary Figures
View article: Supplementary Table 1 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions
Supplementary Table 1 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions Open
Supplementary Table 1
View article: Data from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions
Data from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions Open
Several solid malignancies trigger lymphangiogenesis, facilitating metastasis. Tumor-associated lymphatic vessels significantly contribute to the generation of an immunosuppressive tumor microenvironment (TME). Here, we have investigated t…
View article: Supplementary Figures 1-12 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions
Supplementary Figures 1-12 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions Open
Supplementary Figures and Legends
View article: Supplementary Methods, Figure Legends from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes
Supplementary Methods, Figure Legends from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes Open
PDF file - 254K
View article: Supplementary Figure 2 from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes
Supplementary Figure 2 from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes Open
PDF file - 51K, NP-conjugated OVA and CpG induces functional OVA257-264-specific CD8+ T cells and antibodies.
View article: Supplementary Figure 6 from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes
Supplementary Figure 6 from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes Open
PDF file - 22K, As the tumor progresses, OVA expression decreases in the tumor.
View article: Supplementary figure legends from Nanoparticle Conjugation of Human Papillomavirus 16 E7-long Peptides Enhances Therapeutic Vaccine Efficacy against Solid Tumors in Mice
Supplementary figure legends from Nanoparticle Conjugation of Human Papillomavirus 16 E7-long Peptides Enhances Therapeutic Vaccine Efficacy against Solid Tumors in Mice Open
This file contains the figure legends relative to all the supplementary figures.
View article: Data from Nanoparticle Conjugation of Human Papillomavirus 16 E7-long Peptides Enhances Therapeutic Vaccine Efficacy against Solid Tumors in Mice
Data from Nanoparticle Conjugation of Human Papillomavirus 16 E7-long Peptides Enhances Therapeutic Vaccine Efficacy against Solid Tumors in Mice Open
Treatment of patients bearing human papillomavirus (HPV)-related cancers with synthetic long-peptide (SLP) therapeutic vaccines has shown promising results in clinical trials against premalignant lesions, whereas responses against later st…
View article: Supplementary Figure 1 from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes
Supplementary Figure 1 from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes Open
PDF file - 37K, NPs target the tdLN.
View article: Supplementary Figure 6 from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes
Supplementary Figure 6 from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes Open
PDF file - 22K, As the tumor progresses, OVA expression decreases in the tumor.
View article: Supplementary Methods, Figure Legends from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes
Supplementary Methods, Figure Legends from Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes Open
PDF file - 254K