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View article: Initial Findings on the Use of [<sup>225</sup>Ac]Ac-DOTATATE Therapy as a Theranostic Application in Patients with Neuroendocrine Tumors
Initial Findings on the Use of [<sup>225</sup>Ac]Ac-DOTATATE Therapy as a Theranostic Application in Patients with Neuroendocrine Tumors Open
The preliminary results of this study suggest that [225Ac]Ac-DOTATATE is stable, safe, and effective for treating advanced and [177Lu] Lu-DOTATATE-refractory NETs. However, prospective studies are needed to determine the impact of treatmen…
View article: Targeted Alpha Therapy - Promising Radionuclides Beyond Ac-225
Targeted Alpha Therapy - Promising Radionuclides Beyond Ac-225 Open
GirişHedefe yönelik tedavinin tümör dokuları üzerindeki etkisi, modern, temel ve pratik onkolojinin önemli bir konusudur.Hedefe yönelik tedavi esas olarak, sağlıklı dokuları etkilemeden kanser hücrelerine özgü belirteçlere (reseptör vb.) s…
View article: Clinical Experience with [<sup>225</sup>Ac]Ac-PSMA Treatment in Patients with [<sup>177</sup>Lu]Lu-PSMA–Refractory Metastatic Castration-Resistant Prostate Cancer
Clinical Experience with [<sup>225</sup>Ac]Ac-PSMA Treatment in Patients with [<sup>177</sup>Lu]Lu-PSMA–Refractory Metastatic Castration-Resistant Prostate Cancer Open
For patients with advanced-stage metastatic castration-resistant prostate cancer (mCRPC) who do not respond to [177Lu]Lu-PSMA therapy, there are limited treatment options. Clinical results obtained with [225Ac]Ac-PSMA are promising. We ret…
View article: Ge-68/Ga-68 Generators and Current Approach to Ga-68 Radiopharmaceuticals
Ge-68/Ga-68 Generators and Current Approach to Ga-68 Radiopharmaceuticals Open
GirişGe-68/Ga-68Jeneratörleri , , ana radyonüklid] radyoaktif bozunma ürünüdür.Ge-68, kararlı Galyum-69 (Ga-69) izotopundan [Ga-69 (p,2n) Ge-68] yüksek enerjili siklotrondan elde edilir.Günümüzde Ga-68 radyoizotopunu elde etmenin en yaygın…
View article: Targeted Alpha Radionuclide Therapy (TAT)-Ac-225 Radiopharmaceuticals
Targeted Alpha Radionuclide Therapy (TAT)-Ac-225 Radiopharmaceuticals Open
GirişHedefe yönelik alfa (α) radyonüklid tedavisi (targeted alpha-particle therapy -TAT), özellikle çoklu mikrometastazları olan ileri dönem kanserlerin tedavisinde, hedefe yönelik beta (β-) radyonüklid tedavinin (TBT) etkinlik gösteremedi…
View article: Leukocyte Labeling with Tc-99m-HMPAO: The Role of Leucocyte Numbers and Medication on the Labeling Efficacy and Image Quality
Leukocyte Labeling with Tc-99m-HMPAO: The Role of Leucocyte Numbers and Medication on the Labeling Efficacy and Image Quality Open
Tc-99m-HMPAO was labeled with leukocytes successfully, and Tc-99m-HMPAO-labeled leukocytes was safely injected to the patients as sterile without loss of vitality and aggregation.
View article: Almost Complete Response with a Single Administration <sup>225</sup>Ac-DOTATATE in a Patient with a Metastatic Neuroendocrine Tumor of Unknown Primary
Almost Complete Response with a Single Administration <sup>225</sup>Ac-DOTATATE in a Patient with a Metastatic Neuroendocrine Tumor of Unknown Primary Open
Neuroendocrine tumors (NETs) are being seen increasingly frequently, and the only known curative treatment method is surgical resection. Peptide receptor radionuclide therapy (PRRT) is a treatment option that the most contributes to progre…
View article: Recent Developments of Radiopharmaceuticals for Neuroendocrine Tumor Imaging and Therapy
Recent Developments of Radiopharmaceuticals for Neuroendocrine Tumor Imaging and Therapy Open
ÖzNükleer tıp son yıllarda nöroendokrin neoplazi (NEN) hastalarının yönetiminde önemli rol oynamaktadır.Radyoişaretli somatostatin reseptör (sstr) analogları günümüzde NEN'in görüntüleme ve tedavisi için kullanılan en gelişmiş radyofarmasö…
View article: Guideline on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals
Guideline on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals Open
This guideline on current good radiopharmacy practice (cGRPP) for small-scale preparation of radiopharmaceuticals represents the view of the Radiopharmacy Committee of the European Association of Nuclear Medicine (EANM). The guideline is l…
View article: The Role of 68GA-PSMA PET/CT Scan In Patients with Prostate Adenocarcinoma who Underwent Radical Prostatectomy.
The Role of 68GA-PSMA PET/CT Scan In Patients with Prostate Adenocarcinoma who Underwent Radical Prostatectomy. Open
The 68Ga-PSMA PET/CT scan accurately demonstrates intraprostatic tumor localization in high-risk group and presence of seminal vesicle involvement, which can help to accurately detect the target lesion before prostate biopsy. In addition, …
View article: Performance of F-18 Fluorocholine PET/CT for Detection of Hyperfunctioning Parathyroid Tissue in Patients with Elevated Parathyroid Hormone Levels and Negative or Discrepant Results in conventional Imaging
Performance of F-18 Fluorocholine PET/CT for Detection of Hyperfunctioning Parathyroid Tissue in Patients with Elevated Parathyroid Hormone Levels and Negative or Discrepant Results in conventional Imaging Open
FCH PET/CT is an effective imaging modality for detection of HPT with the highest sensitivity among the available imaging techniques. Therefore, FCH PET/CT can be recommended especially for patients who show negative or inconclusive result…
View article: <sup>64</sup> Cu-Labeled Phosphonate Cross-Bridged Chelator Conjugates of c(RGDyK) for PET/CT Imaging of Osteolytic Bone Metastases
<sup>64</sup> Cu-Labeled Phosphonate Cross-Bridged Chelator Conjugates of c(RGDyK) for PET/CT Imaging of Osteolytic Bone Metastases Open
These data suggest that the phosphonate chelator conjugates of c(RDGyK) peptides are promising PET tracers suitable for imaging tumor-associated osteoclasts in bone metastases.
View article: Lu-177-PSMA-617 Prostate-Specific Membrane Antigen Inhibitor Therapy in Patients with Castration-Resistant Prostate Cancer: Stability, Bio-distribution and Dosimetry
Lu-177-PSMA-617 Prostate-Specific Membrane Antigen Inhibitor Therapy in Patients with Castration-Resistant Prostate Cancer: Stability, Bio-distribution and Dosimetry Open
Lu-177-PSMA-617 is a highly stable compound both in vitro and in vivo. Lu-177-PSMA-617 therapy seems to be a safe method for the treatment of castration-resistant prostate cancer patients. The fractionation regime that enables the longest …
View article: Preclinical Evaluation of <sup>18</sup>F-ML-10 to Determine Timing of Apoptotic Response to Chemotherapy in Solid Tumors
Preclinical Evaluation of <sup>18</sup>F-ML-10 to Determine Timing of Apoptotic Response to Chemotherapy in Solid Tumors Open
Purpose: We investigated 2-(5-fluoro-pentyl)-2-methyl-malonic acid ( 18 F-ML-10) positron emission tomography (PET) imaging of apoptosis posttherapy to determine optimal timing for predicting chemotherapy response in a mouse head/neck xeno…
View article: The role of 68Ga-DOTA-TATE PET/CT scanning in the evaluation of patients with multiple myeloma
The role of 68Ga-DOTA-TATE PET/CT scanning in the evaluation of patients with multiple myeloma Open
TATE PET/CT seems to be an alternative imaging modality and may play a complementary role in MM management, at least by providing a different pathobiological insight into the disease.