Memet Emin
YOU?
Author Swipe
View article: Yes-associated protein induces age-dependent inflammatory signaling in the pulmonary endothelium
Yes-associated protein induces age-dependent inflammatory signaling in the pulmonary endothelium Open
Like human patients, adult mice get worse lung injury than juveniles. In pneumonia-induced lung injury, Yes-associated protein is more highly expressed in the endothelium of adult mice than juveniles, causing more NF-κB nuclear translocati…
View article: Yes-associated Protein Induces Age-dependent Inflammatory Signaling in the Pulmonary Endothelium
Yes-associated Protein Induces Age-dependent Inflammatory Signaling in the Pulmonary Endothelium Open
Acute Lung Injury (ALI) causes the highly lethal Acute Respiratory Distress Syndrome (ARDS) in children and adults, for which therapy is lacking. Children with Pediatric ARDS (PARDS) have a mortality rate that is about half of adults with …
View article: Mild sleep restriction increases endothelial oxidative stress in female persons
Mild sleep restriction increases endothelial oxidative stress in female persons Open
Sleep restriction is associated with increased cardiovascular risk, which is more pronounced in female than male persons. We reported recently first causal evidence that mild, prolonged sleep restriction mimicking “real-life” conditions im…
View article: Mitochondria of lung venular capillaries mediate lung-liver cross talk in pneumonia
Mitochondria of lung venular capillaries mediate lung-liver cross talk in pneumonia Open
We report that mitochondrial injury in lung venular capillaries underlies barrier failure in pneumonia, and venular capillary uncoupling protein 2 (UCP2) causes neutrophil-mediated liver congestion. Using in situ imaging, we found that epi…
View article: Statins Restore Endothelial Protection against Complement Activity in Obstructive Sleep Apnea: A Randomized Clinical Trial
Statins Restore Endothelial Protection against Complement Activity in Obstructive Sleep Apnea: A Randomized Clinical Trial Open
Rationale: Increased cardiovascular risk in obstructive sleep apnea (OSA) persists after continuous positive airway pressure (CPAP) and alternative therapies are needed. Impaired endothelial protection against complement is a cholesterol-d…
View article: Sleep Deprivation Impairs Vascular Function in Healthy Women: A Clinical Trial
Sleep Deprivation Impairs Vascular Function in Healthy Women: A Clinical Trial Open
"Sleep Deprivation Impairs Vascular Function in Healthy Women: A Clinical Trial." Annals of the American Thoracic Society, 19(12), pp. 2097–2100
View article: Continuous Positive Airway Pressure Does Not Restore Endothelial Complement Inhibition in Obstructive Sleep Apnea
Continuous Positive Airway Pressure Does Not Restore Endothelial Complement Inhibition in Obstructive Sleep Apnea Open
Rationale: Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease.The internalization of CD59, a major complement inhibitor, from the endothelial cell (EC) surface triggers endothelial inflammation in OSA, a…
View article: Complement promotes endothelial von Willebrand factor and angiopoietin-2 release in obstructive sleep apnea
Complement promotes endothelial von Willebrand factor and angiopoietin-2 release in obstructive sleep apnea Open
Study Objective Obstructive sleep apnea (OSA) is highly prevalent and triples vascular thromboembolic risk. Intermittent hypoxia (IH) during transient cessation of breathing in OSA impairs endothelial protection against complement. Complem…
View article: Effects of Inadequate Sleep on Blood Pressure and Endothelial Inflammation in Women: Findings From the American Heart Association Go Red for Women Strategically Focused Research Network
Effects of Inadequate Sleep on Blood Pressure and Endothelial Inflammation in Women: Findings From the American Heart Association Go Red for Women Strategically Focused Research Network Open
Background Insufficient sleep increases blood pressure. However, the effects of milder, highly prevalent but frequently neglected sleep disturbances, including poor sleep quality and insomnia, on vascular health in women are unclear. We in…
View article: Increased internalization of complement inhibitor CD59 may contribute to endothelial inflammation in obstructive sleep apnea
Increased internalization of complement inhibitor CD59 may contribute to endothelial inflammation in obstructive sleep apnea Open
Reduced protection against complement attack mediates endothelial inflammation in obstructive sleep apnea.