Dilani Lokuhetty
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View article: Somatic genetic variants associated with aggressiveness of urothelial bladder cancer: a prospective cohort study
Somatic genetic variants associated with aggressiveness of urothelial bladder cancer: a prospective cohort study Open
Background Bladder cancer risk assessment using single nucleotide variants (SNVs) has focused on Caucasian and Chinese patients, with a significant gap in under-represented South Asian populations. This study examines the association of so…
View article: Exploratory evidence maps for the WHO Classification of Tumours 5th edition for lung and thymus tumors
Exploratory evidence maps for the WHO Classification of Tumours 5th edition for lung and thymus tumors Open
View article: Assessment of adult renal cell carcinoma types presenting to a tertiary care hospital in Sri Lanka and the intraobserver variability of two nuclear grading systems for clear cell renal cell carcinoma
Assessment of adult renal cell carcinoma types presenting to a tertiary care hospital in Sri Lanka and the intraobserver variability of two nuclear grading systems for clear cell renal cell carcinoma Open
: The histomorphology remains the foundation in classification of renal cell carcinoma (RCC). The nuclear grading is significant in prognostication of certain subtypes for which Fuhrman system was used before the introduction of WHO/ISUP s…
View article: Mapping the cited evidence of ductal carcinoma <i>in situ</i> from the 5th edition of the World Health Organisation classification of tumours of the breast
Mapping the cited evidence of ductal carcinoma <i>in situ</i> from the 5th edition of the World Health Organisation classification of tumours of the breast Open
Aims Ductal carcinoma in situ (DCIS) is recognised by the World Health Organisation (WHO) Classification of Tumours (WCT) as a non‐invasive neoplastic epithelial proliferation confined to the mammary ducts and lobules. This report categori…
View article: Moving Forward on Tumor Pathology Research Reporting: A Guide for Pathologists From the World Health Organization Classification of Tumors Living Evidence Gap Map by Tumour Type Group
Moving Forward on Tumor Pathology Research Reporting: A Guide for Pathologists From the World Health Organization Classification of Tumors Living Evidence Gap Map by Tumour Type Group Open
Evidence-based medicine (EBM) can be an unfamiliar territory for those working in tumor pathology research, and there is a great deal of uncertainty about how to undertake an EBM approach to planning and reporting histopathology-based stud…
View article: Anti-anemic properties of Pterocarpus marsupium latex and its cytotoxic and embryotoxic effects.
Anti-anemic properties of Pterocarpus marsupium latex and its cytotoxic and embryotoxic effects. Open
Anemia is a hematological disorder, and a large number in the developing world are affected with significant morbidity and mortality. Among them, most depend on traditional medicine to strengthen the hematopoietic action. The availability,…
View article: A New Hierarchy of Research Evidence for Tumor Pathology: A Delphi Study to Define Levels of Evidence in Tumor Pathology
A New Hierarchy of Research Evidence for Tumor Pathology: A Delphi Study to Define Levels of Evidence in Tumor Pathology Open
The hierarchy of evidence is a fundamental concept in evidence-based medicine, but existing models can be challenging to apply in laboratory-based health care disciplines, such as pathology, where the types of evidence and contexts are sig…
View article: Resection margins and lymph node clearance in open and laparoscopic colorectal cancer surgery; A prospective cohort study
Resection margins and lymph node clearance in open and laparoscopic colorectal cancer surgery; A prospective cohort study Open
A pre-tested interviewer-administered questionnaire was used to assess the adoption of laparoscopic approach by Sri Lankan surgeons who perform surgery for CRC. Data was collected prospectively from consecutive patients who underwent open …
View article: Proliferative epithelial changes in tumour adjacent tissue in Sri Lankan women with breast carcinoma: do morphological changes support molecular models of breast carcinogenesis?
Proliferative epithelial changes in tumour adjacent tissue in Sri Lankan women with breast carcinoma: do morphological changes support molecular models of breast carcinogenesis? Open
View article: Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities? Open
View article: The World Health Organization Classification of Tumors and External Quality Assurance for Immunohistochemistry and Molecular Pathology
The World Health Organization Classification of Tumors and External Quality Assurance for Immunohistochemistry and Molecular Pathology Open
Context.— This article is based on a talk given by the lead author at the Eigth Annual Princeton Integrated Pathology Symposium: Breast Pathology, on Sunday, April 11, 2021. Objective.— To show how the World Health Organization (WHO) Class…
View article: Bilateral Leydig Cell Hyperplasia: A Rare Cause of Postmenopausal Hirsutism
Bilateral Leydig Cell Hyperplasia: A Rare Cause of Postmenopausal Hirsutism Open
Background. Postmenopausal hirsutism could be due to a myriad of causes, including ovarian and adrenal tumours, ovarian hyperthecosis, exogenous androgens, and Cushing’s syndrome. We report a patient who was found to have a rare cause of p…
View article: Identification of potentially misleading terminology in the fifth edition WHO Classification of Tumours digestive and breast tumours blue books
Identification of potentially misleading terminology in the fifth edition WHO Classification of Tumours digestive and breast tumours blue books Open
View article: Counting mitoses: SI(ze) matters!
Counting mitoses: SI(ze) matters! Open
View article: Androgen receptor expression in a Sri Lankan patient cohort with early breast carcinoma
Androgen receptor expression in a Sri Lankan patient cohort with early breast carcinoma Open
Background Androgen receptor (AR) expression is emerging as a prognostic biomarker in breast carcinoma (BCa). The study aimed to determine the prevalence of AR expression by immunohistochemical analysis among a cohort of Sri Lankan women w…
View article: Invited commentary—<scp>WHO</scp> Classification of Tumours: How should tumors be classified? Expert consensus, systematic reviews or both?
Invited commentary—<span>WHO</span> Classification of Tumours: How should tumors be classified? Expert consensus, systematic reviews or both? Open
The World Health Organization (WHO) Classification of Tumors series, published as the WHO Blue Books (Fig. 1) and the accompanying website, are essential resources for pathologists across the globe, providing the standards against which tu…
View article: The 2019 World Health Organization classification of tumours of the breast
The 2019 World Health Organization classification of tumours of the breast Open
The newly published World Health Organization (WHO) Classification of Tumours of the breast features significant changes compared to earlier editions. In this review, we outline the major changes in this important reference source for thos…
View article: A clinicopathological study of triple-negative breast carcinoma in a patient cohort from a tertiary care center in Sri Lanka
A clinicopathological study of triple-negative breast carcinoma in a patient cohort from a tertiary care center in Sri Lanka Open
Twenty four percent were TNBCs by immunohistochemical analysis, comparable to studies in the Indian subcontinent, however higher than the West. TNBC status correlated with younger age, high tumor grade, necrosis, absent DCIS, reduced vascu…
View article: Giant variant of acquired perforating dermatosis, clinically masquerading as a sarcoma: A report of a rare case
Giant variant of acquired perforating dermatosis, clinically masquerading as a sarcoma: A report of a rare case Open
Acquired perforating dermatosis is a group of disease characterized by transepidermal elimination of altered dermal constituents of unknown pathogenesis. The giant variant was first described in 2006, as an emerging entity with seven repor…
View article: A clinico-pathological study of non-urothelial bladder cancers in a cohort of patients from a tertiary care urology unit in Sri Lanka
A clinico-pathological study of non-urothelial bladder cancers in a cohort of patients from a tertiary care urology unit in Sri Lanka Open
Ceylon Medical Journal (CMJ) is a peer-reviewed, open access journal published quarterly by the Sri Lanka Medical Association in the last week of March, June, September and December each year. The mission of the CMJ is to promote the scien…