Menglin Chen
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View article: Integrating bioinformatics and experimental validation to reveal a novel VRK score as a prognostic and therapeutic biomarker in hepatocellular carcinoma
Integrating bioinformatics and experimental validation to reveal a novel VRK score as a prognostic and therapeutic biomarker in hepatocellular carcinoma Open
Background Vaccinia-related kinase (VRK) family genes play a multifunctional role in tumor development. However, the role of VRK family genes in hepatocellular carcinoma (HCC) requires further research. Moreover, the clinical potential of …
View article: Cell Electrospinning: Electrohydrodynamic Effects on Cell Viability and Beyond
Cell Electrospinning: Electrohydrodynamic Effects on Cell Viability and Beyond Open
Electrospinning is a widely used technique for creating nano- to microscale fibers that resembles the fibrous structure of the extracellular matrix (ECM) environment, crucial for tissue engineering and disease modeling. Directly incorporat…
View article: Metacognitive strategies in translation: a comparative study of student and professional translators
Metacognitive strategies in translation: a comparative study of student and professional translators Open
Translation expertise significantly influences how translators manage cognitive resources, yet the specific ways in which professional and novice translators differ in their metacognitive strategy use remain incompletely understood. This g…
View article: The Causal Correlation Between Gastroesophageal Reflux Disease and Chronic Widespread Pain: A Bidirectional Mendelian Randomization Study
The Causal Correlation Between Gastroesophageal Reflux Disease and Chronic Widespread Pain: A Bidirectional Mendelian Randomization Study Open
Our study demonstrated a bidirectional causal relationship between GERD and chronic widespread pain, and future interventions for CWP may be an effective strategy for preventing or mitigating GERD and vice versa.
View article: Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts
Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts Open
Successful application of advanced engineered materials in osteoplasty requires a biological understanding of the recipient reaction. The immune system acts like a double-edged sword by maintaining targeted tissue and rejecting grafts. Nev…
View article: Effects of Exercise and Konjac on Lipid Metabolism and Mechanism in Obese Rats
Effects of Exercise and Konjac on Lipid Metabolism and Mechanism in Obese Rats Open
Objective To study the effects of exercise and konjac on body weight and lipid metabolism in obese rats, and the possible mechanism of exercise combined with konjac on body weight and lipid metabolism. Methods Fifty male Sprague Dawley rat…
View article: Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering
Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering Open
Cell transplantation therapy in the central nervous system is hindered by limited survival and integration of grafted cells. Biomaterials have emerged as an attractive solution to this problem by providing a protective microenvironment to …
View article: Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis Open
Targeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial. Herein, farnesyl‐diphosphate farnesyltransferase 1 (FDFT1) is identifie…
View article: The Lactate‐Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM‐Dependent Mitochondrial Fatty Acid Synthesis
The Lactate‐Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM‐Dependent Mitochondrial Fatty Acid Synthesis Open
Recipients often suffer from hyperlactatemia during liver transplantation (LT), but whether hyperlactatemia exacerbates hepatic ischemia‐reperfusion injury (IRI) after donor liver implantation remains unclear. Here, the role of hyperlactat…
View article: Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner
Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner Open
The global incidence of obesity and its metabolic sequelae, notably metabolic dysfunction-associated steatohepatitis (MASLD), has escalated to epidemic levels. We unveil a previously unknown moonlighting role for arginase 1 (Arg1) in facil…
View article: Biomimic opto-nanobiointerface enables multiscale biomodulation
Biomimic opto-nanobiointerface enables multiscale biomodulation Open
Virtually all organic material on Earth has been produced converting solar energy through photosynthesis in chloroplasts, a sack-like, double membrane organelle in plants and algae, where transmembrane electron transfer occurs from lumen t…
View article: Mechanical memory based biofabrication of hierarchical elastic cardiac tissue
Mechanical memory based biofabrication of hierarchical elastic cardiac tissue Open
Mimicking the multilayered, anisotropic, elastic structure of cardiac tissues for controlled guidiance of 3D cellular orientation is essential in designing bionic scaffolds for cardiac tissue biofabrication. Here, a hierarchically organize…
View article: Optoelectronic stimuli-driven switchable memristors with multilevel resistance states for neuromorphic vision sensors
Optoelectronic stimuli-driven switchable memristors with multilevel resistance states for neuromorphic vision sensors Open
The developed optoelectronic synaptic devices with resistive switching enable efficient, fault-resistant image recognition. The PMMA/ZnO/2IF memristor array advances neuromorphic vision systems, offering high accuracy and low power consump…
View article: Oriented Hydrogels with Wireless Electromagnetic Cues Direct Neural Morphogenesis Across Central and Peripheral Systems
Oriented Hydrogels with Wireless Electromagnetic Cues Direct Neural Morphogenesis Across Central and Peripheral Systems Open
Electrical signaling underpins neural activity, yet the soft, anisotropic extracellular matrix plays a decisive role in shaping neuronal morphogenesis. To leverage this interplay, we integrated a wireless electromagnetic stimulation system…
View article: Suppression of STK39 weakens the MASLD/MASH process by protecting the intestinal barrier
Suppression of STK39 weakens the MASLD/MASH process by protecting the intestinal barrier Open
STK39 is reportedly a critical negative regulator of intestinal barrier. Pharmacological targeting of STK39 is expected to protect the intestinal barrier and thereby weaken metabolic dysfunction-associated steatohepatitis (MASH); Proximal …
View article: The causal correlation between gastroesophageal reflux disease and chronic widespread pain: a bidirectional mendelian randomization study
The causal correlation between gastroesophageal reflux disease and chronic widespread pain: a bidirectional mendelian randomization study Open
Background Previous observational research found a relationship between gastroesophageal reflux disease (GERD) and chronic widespread pain (CWP). Despite this, it is unknown which, if any, of the conditions produces the other. Our study wi…
View article: Embracing Remote Fields as the Fourth Dimension of Tissue Biofabrication
Embracing Remote Fields as the Fourth Dimension of Tissue Biofabrication Open
Biomodulation facilitated by external remote fields, such as those generated by magnetic, optical, and acoustic stimuli, has emerged as an intriguing avenue for tissue biofabrication, owing to their precision and non‐invasive characteristi…
View article: Emerging Strategies for Beta Cell Encapsulation for Type 1 Diabetes Therapy
Emerging Strategies for Beta Cell Encapsulation for Type 1 Diabetes Therapy Open
Diabetes is a prevalent chronic disease affecting millions of people globally. To address this health challenge, advanced beta cell therapy using biomaterials‐based macroscale, microscale, and nanoscale encapsulation devices must tackle va…
View article: Spatially engineering tri-layer nanofiber dressings featuring asymmetric wettability for wound healing
Spatially engineering tri-layer nanofiber dressings featuring asymmetric wettability for wound healing Open
Inspired by the skin structure, an asymmetric wettability tri-layer nanofiber membrane (TNM) consisting of hydrophilic inner layer loaded with lidocaine hydrochloride (LID), hydrophobic middle layer with ciprofloxacin (CIP) and hydrophobic…
View article: Aminated graphene quantum dots/CdS nanobelts for enhanced photocatalytic degradation of RhB dye under visible light
Aminated graphene quantum dots/CdS nanobelts for enhanced photocatalytic degradation of RhB dye under visible light Open
CdS nanoparticles have wide applications as photocatalysts for degradation of organic pollutants, but due to their limited turnover number and off-pathway charge recombination processes, their degradation efficiency is low.
View article: Peripheral Injection of hUC‐MSCs in the Treatment of Acute Liver Failure: A Pre‐Clinical Cohort Study in Rhesus Monkeys
Peripheral Injection of hUC‐MSCs in the Treatment of Acute Liver Failure: A Pre‐Clinical Cohort Study in Rhesus Monkeys Open
Background . Using a toxin‐induced lethal acute liver failure (ALF) monkey model, we have recently shown that early peripheral infusion of human umbilical cord mesenchymal stem cells (hUC‐MSCs) can alleviate liver damage and improve animal…
View article: Characterization of 10 nm – 10 μm coal dust particles generated by simulated different cutting and drilling parameters: mass concentration distribution, number concentration distribution, and fractal dimension
Characterization of 10 nm – 10 μm coal dust particles generated by simulated different cutting and drilling parameters: mass concentration distribution, number concentration distribution, and fractal dimension Open
Nano-to-micron-sized coal dust can cause coal workers’ pneumoconiosis (CWP), and cutting and drilling are the main coal dust-generating processes. Based on a self-developed simulated coal cutting and drilling dust generation system, the ef…