Hanlin Wang
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View article: Porto-sinusoidal vascular disorder (PSVD): Survey-based analysis of the usage and drawbacks of this newly proposed terminology
Porto-sinusoidal vascular disorder (PSVD): Survey-based analysis of the usage and drawbacks of this newly proposed terminology Open
The term "porto-sinusoidal vascular disorder" (PSVD) has been proposed for morphologic findings commonly seen in non-cirrhotic portal hypertension (PH) but can also be observed without clinically evident PH. To assess current practice patt…
View article: Conbercept combined with 577 nm subthreshold micropulse laser for diabetic macular edema
Conbercept combined with 577 nm subthreshold micropulse laser for diabetic macular edema Open
AIM: To evaluate the efficacy and safety of conbercept combined with 577 nm subthreshold micropulse laser (STML) for treatment of diabetic macular edema (DME). METHODS: A retrospective study was conducted. From October 2022 to March 2024, …
View article: GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets
GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets Open
The RNA polymerase II (RNA pol II) complex is essential for gene transcription throughout life, and numerous cofactors have been identified as critical for diverse transcriptional processes. Herein, it is discovered that the RNA pol II com…
View article: AMPK maintains the activation of hepatic stellate cells through mitophagy-induced metabolic reprogramming
AMPK maintains the activation of hepatic stellate cells through mitophagy-induced metabolic reprogramming Open
The activation of hepatic stellate cells (HSCs), characterized by transdifferentiation from a quiescent state to a fibrogenic phenotype, is a core process of liver fibrosis. The metabolic reprogramming of HSCs plays a major role in this pr…
View article: Integrated Analysis of <scp>GC</scp> – <scp>MS</scp> ‐Based Metabolomics and Proteomics Reveals the Importance of Volatile Metabolite Stigmasterol in the Defence Response of <i>Panax notoginseng</i> Against Root Rot
Integrated Analysis of <span>GC</span> – <span>MS</span> ‐Based Metabolomics and Proteomics Reveals the Importance of Volatile Metabolite Stigmasterol in the Defence Response of <i>Panax notoginseng</i> Against Root Rot Open
Root rot disease in Panax notoginseng , primarily caused by the pathogenic fungus Fusarium solani , significantly impacts the growth and production of this medicinal herb. To elucidate the defence mechanisms of P. notoginseng against root …
View article: Risk factors for mild cognitive impairment in type 2 diabetes: a systematic review and meta-analysis
Risk factors for mild cognitive impairment in type 2 diabetes: a systematic review and meta-analysis Open
Background Mild Cognitive Impairment (MCI), a transition between normal aging and dementia, is linked to higher dementia risk and potential reversibility. Type 2 Diabetes Mellitus (T2DM), affecting over 537 million adults worldwide, increa…
View article: Subgenual anterior cingulate cortex functional connectivity abnormalities in depression: insights from brain imaging big data and precision-guided personalized intervention via transcranial magnetic stimulation
Subgenual anterior cingulate cortex functional connectivity abnormalities in depression: insights from brain imaging big data and precision-guided personalized intervention via transcranial magnetic stimulation Open
The subgenual anterior cingulate cortex (sgACC) plays a central role in the pathophysiology of major depressive disorder (MDD). Its functional interactive profile with the left dorsal lateral prefrontal cortex (DLPFC) is associated with tr…
View article: Reasoning Beyond Language: A Comprehensive Survey on Latent Chain-of-Thought Reasoning
Reasoning Beyond Language: A Comprehensive Survey on Latent Chain-of-Thought Reasoning Open
Large Language Models (LLMs) have shown impressive performance on complex tasks through Chain-of-Thought (CoT) reasoning. However, conventional CoT relies on explicitly verbalized intermediate steps, which constrains its broader applicabil…
View article: Associations of metal exposure with chest pain incidence and mortality in nonpregnant adults: Based on NHANES data
Associations of metal exposure with chest pain incidence and mortality in nonpregnant adults: Based on NHANES data Open
Heavy metals are widespread environmental contaminants that have attracted considerable attention because of the potential human health risks. Heavy metals can lead to cardiovascular disease and chest pain is the most common precursor symp…
View article: ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13
ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13 Open
Peroxisomes are integral metabolic organelles involved in both catabolic and anabolic processes in humans, with defects linked to diseases. The functions of peroxisomes are regulated at transcriptional, translational, and posttranslational…
View article: Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK
Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK Open
Obesity is regarded as a chronic inflammatory disease involving adipose tissue macrophages (ATM), but whether immunometabolic reprogramming of ATM affects obesity remains unclarified. Here we show that in ATM glutaminolysis is the fundamen…
View article: Recent advances in the biosynthesis of polysaccharide-based antimicrobial glycoconjugate vaccines
Recent advances in the biosynthesis of polysaccharide-based antimicrobial glycoconjugate vaccines Open
Glycoconjugate vaccines are a vital category of effective and safe commercial vaccines that have significantly reduced the global prevalence of drug-resistant bacterial infections. These vaccines are synthesized by covalently linking bacte…
View article: Moderating effects of chord progressions on the emotional experience of major and minor chords
Moderating effects of chord progressions on the emotional experience of major and minor chords Open
Numerous studies have shown the major chords express positive emotions, while minor chords convey negative emotions. However, several research suggest that the association between major/minor chords and emotional valence may vary due to ce…
View article: CT-based habitat radiomics for predicting treatment response to neoadjuvant chemoimmunotherapy in esophageal cancer patients
CT-based habitat radiomics for predicting treatment response to neoadjuvant chemoimmunotherapy in esophageal cancer patients Open
Introduction We used habitat radiomics as an innovative tumor biomarker to predict the outcome of neoadjuvant therapy for esophageal cancer. Methods This was a two-center retrospective clinical study in which pretreatment CT scans of 112 p…
View article: Systematic analysis of functional implications of fibrosis in pan-cancer
Systematic analysis of functional implications of fibrosis in pan-cancer Open
The common pathogenic mechanisms and molecular pathways of fibrosis and tumors remain unclear. We aimed to conduct in-depth analysis of fibrosis feature genes role from a pan-cancer perspective and identify potential therapeutic targets fo…
View article: HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma
HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma Open
Upon infection with herpes simplex virus 1 (HSV-1), the virus deploys multiple strategies to evade the host's innate immune response. However, the mechanisms governing this phenomenon remain elusive. Here, we find that HSV-1 leads to a dec…
View article: CRISPR screens reveal ZBTB17/MIZ1 as a peroxisome regulator
CRISPR screens reveal ZBTB17/MIZ1 as a peroxisome regulator Open
Peroxisomes are integral metabolic organelles involved in both catabolic and anabolic processes in humans, with defects often linked to diseases. The functions of peroxisomes are regulated at transcriptional, translational, and post-transl…
View article: Open-Event Procedure Planning in Instructional Videos
Open-Event Procedure Planning in Instructional Videos Open
Given the current visual observations, the traditional procedure planning task in instructional videos requires a model to generate goal-directed plans within a given action space. All previous methods for this task conduct training and in…
View article: Understanding tightened muscle in knee osteoarthritis and the impacts of Fu’s subcutaneous needling: A pilot trial with shear-wave elastography and near-infrared spectroscopy
Understanding tightened muscle in knee osteoarthritis and the impacts of Fu’s subcutaneous needling: A pilot trial with shear-wave elastography and near-infrared spectroscopy Open
Background: Given the scarce reports on the interplay between Fu’s subcutaneous needling (FSN), tightened muscle, and therapeutic effects, we developed a clinical research protocol to synchronously collect data on clinical efficacy and mus…
View article: Construction of a bioinformatics-based prognostic model related to liquid-liquid phase separation in lung adenocarcinoma
Construction of a bioinformatics-based prognostic model related to liquid-liquid phase separation in lung adenocarcinoma Open
It was reported that liquid-liquid phase separation (LLPS) related genes (LRGs) were involved in the prognosis of a variety of tumors. We aimed to investigate the impact of LRGs on lung adenocarcinoma (LUAD) patients' prognosis, providing …
View article: DPABI harmonization: A toolbox for harmonizing multi-site brain imaging for big-data era
DPABI harmonization: A toolbox for harmonizing multi-site brain imaging for big-data era Open
Pooling multi-site datasets is the dominant trend to expand sample sizes in neuroimaging field, thereby enhancing statistical power and reproducibility of research findings. Nevertheless, the heterogeneity derived from aggregating data fro…
View article: Primary mediastinal choriocarcinoma in an 18‐year‐old male with pulmonary and brain metastasis: A case report
Primary mediastinal choriocarcinoma in an 18‐year‐old male with pulmonary and brain metastasis: A case report Open
Primary mediastinal choriocarcinoma, also known as non‐pregnant choriocarcinoma, is a rare malignancy unrelated to pregnancy, with a higher incidence in males. And primary mediastinal choriocarcinoma is mostly associated with organ and lym…