Mengjie Wu
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View article: Intelligent microstructure materials for diagnosis and treatment of osteoarthritis: progress and AI-enpowered future
Intelligent microstructure materials for diagnosis and treatment of osteoarthritis: progress and AI-enpowered future Open
View article: Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms
Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms Open
Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch, proprioception and visceral sensation. These mechanosensation processes, where mechanical forces are converted into electrochemical signals, ar…
View article: Mevalonate pathway promotes liver cancer by suppressing ferroptosis through CoQ10 production and selenocysteine-tRNA modification
Mevalonate pathway promotes liver cancer by suppressing ferroptosis through CoQ10 production and selenocysteine-tRNA modification Open
Current therapies show limited efficacy for advanced hepatocellular carcinoma (HCC). This study demonstrates that targeting the mevalonate pathway induces ferroptosis in HCC by disrupting CoQ10 biosynthesis and selenoprotein translation. C…
View article: Corrigendum to ‘Mandibular lateral shift induces the increased expression of TGF-β, VEGF, and Col-II in the condyle of rat temporomandibular joints’ [Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 114/5S (2012) S167-S173]
Corrigendum to ‘Mandibular lateral shift induces the increased expression of TGF-β, VEGF, and Col-II in the condyle of rat temporomandibular joints’ [Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 114/5S (2012) S167-S173] Open
View article: High-Fructose Diet Aggravates Temporomandibular Joint Cartilage Degeneration
High-Fructose Diet Aggravates Temporomandibular Joint Cartilage Degeneration Open
Temporomandibular joint (TMJ) is the only bilateral joint of craniomaxillofacial region, and temporomandibular joint osteoarthritis (TMJOA) is a common disease in TMJ. The damaged cartilage homeostasis is one of the fundamental causes of T…
View article: Diagnostic performance of apparent diffusion coefficient values in differentiating benign from malignant lesions in prostate PI-RADS v2.1 category 1 “nodules in nodule”
Diagnostic performance of apparent diffusion coefficient values in differentiating benign from malignant lesions in prostate PI-RADS v2.1 category 1 “nodules in nodule” Open
View article: Ultrasound-Based Deep Learning Radiomics Models for Predicting Primary and Secondary Salivary Gland Malignancies: A Multicenter Retrospective Study
Ultrasound-Based Deep Learning Radiomics Models for Predicting Primary and Secondary Salivary Gland Malignancies: A Multicenter Retrospective Study Open
Background: Primary and secondary salivary gland malignancies differ significantly in treatment and prognosis. However, conventional ultrasonography often struggles to differentiate between these malignancies due to overlapping imaging fea…
View article: Prognostic nomogram based on coagulation for individualized prediction after radical resection of hepatocellular carcinoma
Prognostic nomogram based on coagulation for individualized prediction after radical resection of hepatocellular carcinoma Open
View article: Corrigendum to “C-repeat binding factor (CBF) identification and expression pattern to abiotic stress response in Casuarina equisetifolia and overexpression of CeCBF4 increase stress tolerance in Arabidopsis” [Ind. Crops Prod. 222 (2024) 119593]
Corrigendum to “C-repeat binding factor (CBF) identification and expression pattern to abiotic stress response in Casuarina equisetifolia and overexpression of CeCBF4 increase stress tolerance in Arabidopsis” [Ind. Crops Prod. 222 (2024) 119593] Open
View article: Combating mt-dsRNA-Mediated Inflammation in Osteoarthritis: Synergistic Therapy with Cerium-Based Nanozymes and POLRMT Inhibition
Combating mt-dsRNA-Mediated Inflammation in Osteoarthritis: Synergistic Therapy with Cerium-Based Nanozymes and POLRMT Inhibition Open
View article: Dental pulp stem cells promote genioglossus repair and systemic amelioration in chronic intermittent hypoxia
Dental pulp stem cells promote genioglossus repair and systemic amelioration in chronic intermittent hypoxia Open
Obstructive sleep apnea (OSA) leads to chronic intermittent hypoxia (CIH) and is not well addressed by current therapies. The genioglossus (GG) is the largest upper airway dilator controlling OSA pathology, making its repair a potential tr…
View article: A practical risk stratification system based on ultrasonography and clinical characteristics for predicting the malignancy of soft tissue masses
A practical risk stratification system based on ultrasonography and clinical characteristics for predicting the malignancy of soft tissue masses Open
View article: A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells
A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells Open
The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint damage, combined with joint bleedi…
View article: A rare case：IgG4-related gastrointestinal disease disguised as a solitary gastric mass.
A rare case：IgG4-related gastrointestinal disease disguised as a solitary gastric mass. Open
Key Clinical MessageIgG4-related diseases rarely affect the gastrointestinal tract.We reported a 44-year-old man who presented with a solitary gastric mass and was ultimately diagnosed with food-specific IgG4-related gastrointestinal disea…
View article: Development and validation of a deep learning model for predicting postoperative survival of patients with gastric cancer
Development and validation of a deep learning model for predicting postoperative survival of patients with gastric cancer Open
View article: Identification of Stress Responsive NAC Genes in Casuarina equisetifolia L. and Its Expression Analysis under Abiotic Stresses
Identification of Stress Responsive NAC Genes in Casuarina equisetifolia L. and Its Expression Analysis under Abiotic Stresses Open
NAC (NAM, ATAF and CUC)-like transcription factors, a class of plant-specific transcription factors, play a pivotal role in plant growth, development, metabolism, and stress response. Notably, a specific subclass of NAC family, known as SN…
View article: Reduced-toxicity conditioning regimen with low dose post-transplantation cyclophosphamide and low-dose anti-thymocyte globulin as graft-versus-host disease prophylaxis for haploidentical stem cell transplantation in older patients
Reduced-toxicity conditioning regimen with low dose post-transplantation cyclophosphamide and low-dose anti-thymocyte globulin as graft-versus-host disease prophylaxis for haploidentical stem cell transplantation in older patients Open
Reduced-toxicity conditioning (RIC) regimens are used for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in older patients. However, successful outcomes are still hindered by graft-versus-host disease (GVHD), treatment-rela…
View article: Association between Malocclusion and Temporomandibular Joint Disorder: Evidence from Mendelian Randomization Studies
Association between Malocclusion and Temporomandibular Joint Disorder: Evidence from Mendelian Randomization Studies Open
View article: Fibrillarin promotes homologous recombination repair by facilitating the recruitment of recombinase RAD51 to DNA damage sites
Fibrillarin promotes homologous recombination repair by facilitating the recruitment of recombinase RAD51 to DNA damage sites Open
Eukaryotic organisms constantly face a wide range of internal and external factors that cause damage to their DNA. Failure to accurately and efficiently repair these DNA lesions can result in genomic instability and the development of tumo…
View article: Effects of Positive Leadership on Intrinsic Motivation of Inter-professional Collaboration among Medical Staff : A Moderated Effect of Culture
Effects of Positive Leadership on Intrinsic Motivation of Inter-professional Collaboration among Medical Staff : A Moderated Effect of Culture Open
Background Inter-professional collaboration (IPC) is critical to address the issues of fragmented healthcare; however, intrinsic motivation of IPC among medical staff is at a low level. Positive leadership is supposed to have an inference …
View article: 515P A MRI-based radiomics model for predicting the response to anlotinb combined with temozolomide in recurrent malignant glioma patients
515P A MRI-based radiomics model for predicting the response to anlotinb combined with temozolomide in recurrent malignant glioma patients Open
View article: Salubrinal alleviates cartilage degradation in a rabbit temporomandibular joint osteoarthritis model
Salubrinal alleviates cartilage degradation in a rabbit temporomandibular joint osteoarthritis model Open
Objective To investigate and explain the beneficial effects of local intra‐articular injection of Salubrinal on temporomandibular joint osteoarthritis (TMJOA) using a rabbit model of anterior disc displacement (ADD). Methods Rabbits were d…
View article: Nrf2−/− regulated lung DNA demethylation and CYP2E1 DNA methylation under PM2.5 exposure
Nrf2−/− regulated lung DNA demethylation and CYP2E1 DNA methylation under PM2.5 exposure Open
Cytochrome P450 (CYP450) can mediate fine particulate matter (PM 2.5 ) exposure leading to lung injury. Nuclear factor E2-related factor 2 (Nrf2) can regulate CYP450 expression; however, the mechanism by which Nrf2 −/− (KO) regulates CYP45…
View article: Analysis on diagnostic failure of US-guided core needle biopsy for soft tissue tumors
Analysis on diagnostic failure of US-guided core needle biopsy for soft tissue tumors Open
US-guided CNB can be an effective modality for the diagnosis of STTs. The diagnostic yield can be increased when the tumor vascular density was grade III in Color Doppler US, but can be decreased in adipocytic tumors, vascular tumors and m…
View article: Added value of contrast-enhanced ultrasound to conventional ultrasound for characterization of indeterminate soft-tissue tumors
Added value of contrast-enhanced ultrasound to conventional ultrasound for characterization of indeterminate soft-tissue tumors Open
Objective: To assess the added value of contrast-enhanced ultrasound (CEUS) to conventional ultrasound in differentiating benign soft-tissue tumors from malignant ones. Methods: 197 soft-tissue tumors underwent ultrasound examination with …
View article: Chronic intermittent hypoxia impaired collagen synthesis in mouse genioglossus via ROS accumulation: A transcriptomic analysis
Chronic intermittent hypoxia impaired collagen synthesis in mouse genioglossus via ROS accumulation: A transcriptomic analysis Open
Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by intermittent and recurrent upper airway collapse during sleep that leads to chronic intermittent hypoxia (CIH). The genioglossus (GG) is the largest dilat…
View article: mRNA cytidine N4‐acetylation by NAT10 modulates lipid utilization in breast cancer
mRNA cytidine N4‐acetylation by NAT10 modulates lipid utilization in breast cancer Open
When chemical modifications are deposited to mRNA molecules, they get the chance to alter the mRNA fates, including pre-mRNA splicing, mRNA transportation, mRNA stability, mRNA structure and translation efficiency.1 N4-acetylcytidine (ac4C…
View article: Signs and Symptoms of Temporomandibular Dysfunction and Radiographic Condylar Morphology in Patients with Idiopathic Condylar Resorption
Signs and Symptoms of Temporomandibular Dysfunction and Radiographic Condylar Morphology in Patients with Idiopathic Condylar Resorption Open
Background: Little is known about the clinical characteristics of idiopathic condylar resorption (ICR). The aim of this study was to examine the signs and symptoms of temporomandibular dysfunction (TMD) and evaluate the morphological chara…
View article: RNF4 controls the extent of replication fork reversal to preserve genome stability
RNF4 controls the extent of replication fork reversal to preserve genome stability Open
Replication fork reversal occurs via a two-step process that entails reversal initiation and reversal extension. DNA topoisomerase IIalpha (TOP2A) facilitates extensive fork reversal, on one hand through resolving the topological stress ge…
View article: Posaconazole for secondary antifungal prophylaxis in allogeneic stem cell transplantation recipients: a retrospective study
Posaconazole for secondary antifungal prophylaxis in allogeneic stem cell transplantation recipients: a retrospective study Open
Background There is no consensus on the optimal secondary antifungal prophylaxis (SAP) regimen in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The purpose of this study was to evaluate the efficacy and…