Mengyun Wang
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View article: Chemical Constituents and Antiproliferative Activity Against RAFLs and HepG2 Cells of Clematis henryi
Chemical Constituents and Antiproliferative Activity Against RAFLs and HepG2 Cells of Clematis henryi Open
Clematis henryi (C. henryi) is a valuable medicinal plant in the Tujia ethnic family, which is widely used for the treatment of rheumatism arthritis and limb numbness. There are few studies on the chemical composition and biological activi…
View article: Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus
Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus Open
Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the primary histological subtype, and hepatitis B virus (HBV) carriers have a higher risk of HCC. Although several…
View article: Noninvasive Assessment of Ki-67 Expression in Breast Cancer Using Ultrasound Radiomics: A Multi-Institutional Study
Noninvasive Assessment of Ki-67 Expression in Breast Cancer Using Ultrasound Radiomics: A Multi-Institutional Study Open
This dual-center study demonstrates the potential of radiomics models based on US BC images to predict Ki-67 expression accurately. As a non-invasive diagnostic tool, this approach offers valuable support for clinical decision-making and p…
View article: gBRCA1 and gBRCA2 mutations in specific different domains affect ovarian cancer prognosis: A multicenter retrospective study
gBRCA1 and gBRCA2 mutations in specific different domains affect ovarian cancer prognosis: A multicenter retrospective study Open
Background: The prognostic value of germline BRCA1/2 mutations ( gBRCA1/2m ) in ovarian cancer is controversial, and the clinical implications of specific mutation domains within BRCA1/2 remain underexplored. This study aimed to investigat…
View article: Identification and Feeding Characterization of Sterkiella histriomuscorum (Protozoa, Ciliophora, Hypotrichia) Isolated from Outdoor Mass Culture of Scenedesmus dimorphus
Identification and Feeding Characterization of Sterkiella histriomuscorum (Protozoa, Ciliophora, Hypotrichia) Isolated from Outdoor Mass Culture of Scenedesmus dimorphus Open
Herbivorous protistan grazers are ubiquitous and abundant in marine and temperate freshwater environments. However, little is known about the algivorous ciliates and their feeding habits in outdoor mass algal cultures. In this study, we re…
View article: Mid-Level Data Fusion Techniques of LC-MS and HS-GC-MS for Distinguishing Green and Ripe Forsythiae Fructus
Mid-Level Data Fusion Techniques of LC-MS and HS-GC-MS for Distinguishing Green and Ripe Forsythiae Fructus Open
Forsythia suspensa is a crucial plant resource due to its considerable edible and medicinal value. Its fruit, named Forsythiae Fructus (FF), has been widely used in Traditional Chinese Medicine (TCM). According to the fruit maturity stage,…
View article: Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver
Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver Open
View article: DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression
DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression Open
View article: Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients
Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients Open
Background Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic variants within the…
View article: Rapid discovery of a novel “green” and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy
Rapid discovery of a novel “green” and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy Open
View article: N4-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst
N4-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst Open
View article: Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine Kadsura heteroclita (Xuetong)
Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine Kadsura heteroclita (Xuetong) Open
A pair of 3,4- seco -cycloartane triterpenoid isomers with a rare peroxy bridge, namely, xuetonins A and B ( 1 and 2 ), four new lignans xuetonlignans A–D ( 3 – 6 ), a new sesquiterpene xuetonpene ( 7 ), and a new natural product xuetonin …
View article: Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1
Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1 Open
Pleiotropic transcription regulator RNA polymerase II (Pol II)–associated factor 1 (PAF1) governs multiple transcriptional steps and the deposition of several epigenetic marks. However, it remains unclear how ultimate transcriptional outco…
View article: Fibroblast Growth Factor 4 Inhibits Differentiation But Stimulates Proliferation of Rat Stem Leydig Cells
Fibroblast Growth Factor 4 Inhibits Differentiation But Stimulates Proliferation of Rat Stem Leydig Cells Open
View article: Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women
Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women Open
View article: Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity
Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity Open
View article: Clinical significance of miR-1180-3p in hepatocellular carcinoma: a study based on bioinformatics analysis and RT-qPCR validation
Clinical significance of miR-1180-3p in hepatocellular carcinoma: a study based on bioinformatics analysis and RT-qPCR validation Open
miRNAs play an indispensable role in human carcinogenesis. Dysregulated miR-1180-3p has been observed in several types of cancer, including hepatocellular carcinoma (HCC). This study intends to correlate the expression level of miR-1180-3p…
View article: Genome-wide analysis of alternative splicing differences between oocyte and zygote†
Genome-wide analysis of alternative splicing differences between oocyte and zygote† Open
Alternative splicing (AS) of mRNA precursors allows the synthesis of multiple mRNAs from a single primary transcript, significantly expanding the information content and regulatory possibilities of higher eukaryotic genomes. During mammali…
View article: Novel Functional Variants in the Notch Pathway and Survival of Chinese Colorectal Cancer
Novel Functional Variants in the Notch Pathway and Survival of Chinese Colorectal Cancer Open
View article: Functional genetic variants of <i>CTNNBIP1</i> predict platinum treatment response of Chinese epithelial ovarian cancer patients
Functional genetic variants of <i>CTNNBIP1</i> predict platinum treatment response of Chinese epithelial ovarian cancer patients Open
Chemotherapy resistance remains a blockade for successful treatment and longer overall survival of patients with epithelial ovarian cancer (EOC). CTNNBIP1 is an inhibitor of β-catenin that is a chemotherapeutic target for EOC treatment. In…
View article: Marek’s Disease Virus Regulates the Ubiquitylome of Chicken CD4+ T Cells to Promote Tumorigenesis
Marek’s Disease Virus Regulates the Ubiquitylome of Chicken CD4+ T Cells to Promote Tumorigenesis Open
Ubiquitination and deubiquitination of cellular proteins are reciprocal reactions catalyzed by ubiquitination-related enzymes and deubiquitinase (DUB) which regulate almost all cellular processes. Marek’s disease virus (MDV) encodes a vira…
View article: Taming chlorophylls by early eukaryotes underpinned algal interactions and the diversification of the eukaryotes on the oxygenated Earth
Taming chlorophylls by early eukaryotes underpinned algal interactions and the diversification of the eukaryotes on the oxygenated Earth Open
Extant eukaryote ecology is primarily sustained by oxygenic photosynthesis, in which chlorophylls play essential roles. The exceptional photosensitivity of chlorophylls allows them to harvest solar energy for photosynthesis, but on the oth…
View article: Adsorption of chlortetracycline onto biochar derived from corn cob and sugarcane bagasse
Adsorption of chlortetracycline onto biochar derived from corn cob and sugarcane bagasse Open
Biochar was prepared from two different types of biological waste materials, corn cob (CC) and sugarcane bagasse (SB). The adsorption capacity of each class of adsorbent was determined by chlortetracycline (CTC) adsorption tests. The adsor…
View article: Variants in Notch signalling pathway genes, <i><scp>PSEN</scp>1</i> and <i><scp>MAML</scp>2,</i> predict overall survival in Chinese patients with epithelial ovarian cancer
Variants in Notch signalling pathway genes, <i><span>PSEN</span>1</i> and <i><span>MAML</span>2,</i> predict overall survival in Chinese patients with epithelial ovarian cancer Open
To identify genetic variants in Notch signalling pathway genes that may predict survival of Han Chinese patients with epithelial ovarian cancer ( EOC ), we analysed a total of 1273 single nucleotide polymorphisms ( SNP s) within 75 Notch g…
View article: Functional variant of <i>MTOR</i> rs2536 and survival of Chinese gastric cancer patients
Functional variant of <i>MTOR</i> rs2536 and survival of Chinese gastric cancer patients Open
We previously reported that some single nucleotide polymorphisms (SNPs) of candidate genes involved in the MTOR complex1 (MTORC1) were associated with risk of gastric cancer (GCa). In the present study, we further evaluated associations of…
View article: Genetic Variants Within MTORC1 Genes Predict Gastric Cancer Prognosis in Chinese Populations
Genetic Variants Within MTORC1 Genes Predict Gastric Cancer Prognosis in Chinese Populations Open
Objective: Mammalian target of rapamycin complex 1 (mTORC1) plays an important role in maintaining proper cellular functions in gastric cancer (GC). Previous studies demonstrated genetic variants within mTORC1 genes were associated …
View article: An <i>ERCC4</i> regulatory variant predicts grade‐3 or ‐4 toxicities in patients with advanced non‐small cell lung cancer treated by platinum‐based therapy
An <i>ERCC4</i> regulatory variant predicts grade‐3 or ‐4 toxicities in patients with advanced non‐small cell lung cancer treated by platinum‐based therapy Open
Platinum‐based chemotherapy (PBC) in combination with the 3 rd generation drugs is the first‐line treatment for patients with advanced non‐small cell lung cancer (NSCLC); however, the efficacy is severely hampered by grade 3–4 toxicities. …
View article: Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex
Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex Open
Deubiquitinases (DUBs) are essential regulators of intracellular processes involving ubiquitin (Ub) modification. The human DUB ubiquitin-specific protease 1 (hUSP1) interacts with human USP-associated factor 1 (hUAF1), and helps to regula…
View article: Functional variants in the low-density lipoprotein receptor gene are associated with clear cell renal cell carcinoma susceptibility
Functional variants in the low-density lipoprotein receptor gene are associated with clear cell renal cell carcinoma susceptibility Open
Recent studies indicate that abnormal levels of low-density lipoprotein (LDL), which is an important component of dyslipidaemia, are associated with alterations to cancer risk, including that of renal cell carcinoma (RCC). Single nucleotid…
View article: Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapy
Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapy Open