Mengchen Wang
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View article: Manipulating ICG <i>J</i>‐Aggregation and Disaggregation for Imaging‐Guided Cancer Therapy with Self‐Reporting Efficiency
Manipulating ICG <i>J</i>‐Aggregation and Disaggregation for Imaging‐Guided Cancer Therapy with Self‐Reporting Efficiency Open
Integrating imaging guided therapy and therapeutic effect self‐reporting would highly benefit clinic applications. J ‐type aggregates of organic dyes with corresponding photothermal effect have made them popular agents for photoacoustic (P…
View article: Nicotinamide riboside supplementation protects against maternal diabetes-associated decline in oocyte quality
Nicotinamide riboside supplementation protects against maternal diabetes-associated decline in oocyte quality Open
In brief NAD+ levels were reduced in streptozotocin (STZ)-induced diabetic mice, but nicotinamide riboside (NR) supplementation improved these levels in diabetic ovaries and oocytes, enhancing oocyte quality and early embryo development by…
View article: Research on inclination angle design of container loading and unloading platform based on sliding rail type three-dimensional wharf
Research on inclination angle design of container loading and unloading platform based on sliding rail type three-dimensional wharf Open
At present, the traditional container terminal handling system has many problems, such as high energy consumption, high cost and low efficiency. Therefore, this study drew on the characteristics of "hump" transportation to design a sliding…
View article: Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males
Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males Open
Silicon dioxide nanoparticles (SiO 2 NPs) are widely utilized in biomedicine due to their controllable size and biocompatibility. While previous studies have demonstrated that prenatal exposure to SiO 2 NPs can traverse the placental barri…
View article: Optimization of solid-state fermented corn distillers dried grains with solubles: effects on growth performance and tissue morphology in broiler chickens
Optimization of solid-state fermented corn distillers dried grains with solubles: effects on growth performance and tissue morphology in broiler chickens Open
In recent years, the use of corn DDGS has alleviated the problem of protein feed shortages to a certain extent; however, its high mycotoxin content seriously restricts its application in feedstuffs. In this study, the conditions of solid-s…
View article: Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway Open
Ganoderic acid A can inhibit the proliferation and promotes the apoptosis of cancer cells. Surprisingly, the molecular mechanisms underlying the anti-cancer effects of ganoderic acid A still remain poorly defined. Ganoderic acid A derivati…
View article: Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation
Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation Open
Background The inflammatory response is a key factor in the pathogenesis of cerebral ischemia/reperfusion injury (CIRI), and anti-inflammatory interventions may offer a promising therapeutic strategy. Forsythoside B (FB) is a phenylethanoi…
View article: Sestrin1, 2, and 3 are dispensable for female fertility in mice
Sestrin1, 2, and 3 are dispensable for female fertility in mice Open
Background Sestrins have been implicated in regulating aging in various organs through multiple pathways. However, their roles in ovarian aging remain unrevealed. Methods Female Sestrin1 −/− , Sestrin2 −/− , and Sestrin3 −/− mice were gene…
View article: High-Resolution Remote Sensing Imagery for the Recognition of Traditional Villages
High-Resolution Remote Sensing Imagery for the Recognition of Traditional Villages Open
Traditional Chinese villages, vital carriers of traditional culture, have faced significant alterations due to urbanization in recent years, urgently necessitating artificial intelligence data updates. This study integrates high spatial re…
View article: Compound Danshen dripping pills prevent early diabetic retinopathy: roles of vascular protection and neuroprotection
Compound Danshen dripping pills prevent early diabetic retinopathy: roles of vascular protection and neuroprotection Open
Introduction: Diabetic retinopathy (DR) represents a major cause of adult blindness, and early discovery has led to significant increase in the number of patients with DR. The drugs currently used for treatment, such as ranibizumab, mainly…
View article: NADase CD38 is a key determinant of ovarian aging
NADase CD38 is a key determinant of ovarian aging Open
The ovary ages earlier than most other tissues, yet the underlying mechanisms remain elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in young and middle-aged mice revealed that the ovaries showed ear…
View article: Reinforcement Learning with Foundation Priors: Let the Embodied Agent Efficiently Learn on Its Own
Reinforcement Learning with Foundation Priors: Let the Embodied Agent Efficiently Learn on Its Own Open
Reinforcement learning (RL) is a promising approach for solving robotic manipulation tasks. However, it is challenging to apply the RL algorithms directly in the real world. For one thing, RL is data-intensive and typically requires millio…
View article: Use of methylene blue and a spring microcoil in the preoperative localization of small pulmonary nodules under CT guidance: a meta-analysis
Use of methylene blue and a spring microcoil in the preoperative localization of small pulmonary nodules under CT guidance: a meta-analysis Open
Objective Methylene blue (MB) and spring microcoils are used for the preoperative localization of small pulmonary nodules (SPNs). We aimed to compare the efficacy and safety of these methods using published data. Methods We identified rand…
View article: A review of physiological functions of orexin: From instinctive responses to subjective cognition
A review of physiological functions of orexin: From instinctive responses to subjective cognition Open
Orexin, also known as hypocretin, is an excitatory neuropeptide secreted by the hypothalamus. Orexin is divided into orexin-A (OXA) and orexin-B (OXB), which are derived from a common precursor secreted by hypothalamic neurons. Orexin acts…
View article: Revealing the Roles of the JAZ Family in Defense Signaling and the Agarwood Formation Process in Aquilaria sinensis
Revealing the Roles of the JAZ Family in Defense Signaling and the Agarwood Formation Process in Aquilaria sinensis Open
Jasmonate ZIM-domain family proteins (JAZs) are repressors in the signaling cascades triggered by jasmonates (JAs). It has been proposed that JAs play essential roles in the sesquiterpene induction and agarwood formation processes in Aquil…
View article: Shared diagnostic genes and potential mechanism between PCOS and recurrent implantation failure revealed by integrated transcriptomic analysis and machine learning
Shared diagnostic genes and potential mechanism between PCOS and recurrent implantation failure revealed by integrated transcriptomic analysis and machine learning Open
Polycystic ovary syndrome (PCOS) is a complex endocrine metabolic disorder that affects 5–10% of women of reproductive age. The endometrium of women with PCOS has altered immune cells resulting in chronic low-grade inflammation, which attr…
View article: Effects of peroxisome proliferator activated receptor-α agonist on growth performance, blood profiles, gene expression related to liver fat metabolism in broilers fed diets containing corn naturally contaminated with mycotoxins
Effects of peroxisome proliferator activated receptor-α agonist on growth performance, blood profiles, gene expression related to liver fat metabolism in broilers fed diets containing corn naturally contaminated with mycotoxins Open
This study was conducted to determine the subclinical symptom of broilers exposure to mycotxoins from corn naturally contaminated, and the preventive effect with peroxisome proliferator activated receptor-α (PPARα) agonist (Wy-14643) suppl…
View article: Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke
Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke Open
Ischemic stroke is one of the major contributors to death and disability worldwide. Thus, there is an urgent need to develop early brain tissue perfusion therapies following acute stroke and to enhance functional recovery in stroke survivo…
View article: Genomics assisted functional characterization of Bacillus velezensis E as a biocontrol and growth promoting bacterium for lily
Genomics assisted functional characterization of Bacillus velezensis E as a biocontrol and growth promoting bacterium for lily Open
Lily ( Lilium spp.) is one of the most famous ornamental flowers globally. Lily basal rot (also known as root rot or stem rot) and lily gray mold have seriously affected the yield and quality of lily, resulting in huge economic losses. In …
View article: Noncoding RNAs Are Promising Therapeutic Targets for Diabetic Retinopathy: An Updated Review (2017–2022)
Noncoding RNAs Are Promising Therapeutic Targets for Diabetic Retinopathy: An Updated Review (2017–2022) Open
Diabetic retinopathy (DR) is the most common complication of diabetes. It is also the main cause of blindness caused by multicellular damage involving retinal endothelial cells, ganglial cells, and pigment epithelial cells in adults worldw…
View article: Soil Nitrogen Content Detection Based on Near-Infrared Spectroscopy
Soil Nitrogen Content Detection Based on Near-Infrared Spectroscopy Open
Traditional soil nitrogen detection methods have the characteristics of being time-consuming and having an environmental pollution effect. We urgently need a rapid, easy-to-operate, and non-polluting soil nitrogen detection technology. In …
View article: Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential
Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential Open
Hepatocellular carcinoma (HCC) is a complex and heterogeneous malignancy with high incidence and poor prognosis. In addition, owing to the lack of diagnostic and prognostic markers, current multimodal treatment options fail to achieve sati…
View article: Single-cell RNA sequencing in atherosclerosis: Mechanism and precision medicine
Single-cell RNA sequencing in atherosclerosis: Mechanism and precision medicine Open
Atherosclerosis is the pathological basis of various vascular diseases, including those with high mortality, such as myocardial infarction and stroke. However, its pathogenesis is complex and has not been fully elucidated yet. Over the pas…
View article: Bayesian Changepoint Estimation for Spatially Indexed Functional Time Series
Bayesian Changepoint Estimation for Spatially Indexed Functional Time Series Open
We propose a Bayesian hierarchical model to simultaneously estimate mean based changepoints in spatially correlated functional time series. Unlike previous methods that assume a shared changepoint at all spatial locations or ignore spatial…
View article: Probing GPT-3’s Linguistic Knowledge on Semantic Tasks
Probing GPT-3’s Linguistic Knowledge on Semantic Tasks Open
GPT-3 has attracted much attention from both academia and industry. However, it is still unclear what GPT-3 has understood or learned especially in linguistic knowledge. Some studies have shown linguistic phenomena including negation and t…