Mengchen Yang
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View article: Cathepsin S Contributes to Bladder Fibrosis Following Bladder Outlet Obstruction via IL-6 Trans-signaling
Cathepsin S Contributes to Bladder Fibrosis Following Bladder Outlet Obstruction via IL-6 Trans-signaling Open
Background: Bladder outlet obstruction (BOO) frequently accompanies benign prostate hyperplasia (BPH) in aging males and often leads to bladder fibrosis, a secondary pathological change that contributes to bladder dysfunction. The role of …
View article: Genome-wide investigation of transcription factor footprints and dynamics using cFOOT-seq
Genome-wide investigation of transcription factor footprints and dynamics using cFOOT-seq Open
Gene regulation relies on the precise binding of transcription factors (TFs) at regulatory elements, but simultaneously detecting hundreds of TFs on chromatin is challenging. We developed cFOOT-seq, a cytosine deaminase-based TF footprinti…
View article: Effects of Different Land Use Types on Soil Quality and Microbial Diversity in Paddy Soil
Effects of Different Land Use Types on Soil Quality and Microbial Diversity in Paddy Soil Open
This study investigated the effects of three land use patterns—rice (Oryza sativa L.)–rapeseed (Brassica napus L.) rotation (Rapeseed), rice–shrimp (Procambarus clarkii G.) rotation (Shrimp), and the conversion of paddy fields to forestlan…
View article: Serpina3c Mitigates Adipose Tissue Inflammation by Inhibiting the HIF1α-Mediated Endoplasmic Reticulum Overoxidation in Adipocytes
Serpina3c Mitigates Adipose Tissue Inflammation by Inhibiting the HIF1α-Mediated Endoplasmic Reticulum Overoxidation in Adipocytes Open
These findings indicate that Serpina3c is a significant regulator of adipocyte ER redox homeostasis, thus highlighting Serpina3c as a potential therapeutic target for obesity-related eWAT inflammation and heart damage.
View article: Study on Development Pattern and Comprehensive Evaluation of Integration of Urban Underground Space and Rail Transit in China
Study on Development Pattern and Comprehensive Evaluation of Integration of Urban Underground Space and Rail Transit in China Open
China’s urban development has entered the stage of urban renewal, transitioning from large-scale incremental construction to stock enhancement and renovation. In response to challenges such as traffic congestion and land-use constraints, u…
View article: Impact of the “Class B Infectious Disease Class B Management” Policy on the Passenger Volume of Urban Rail Transit: A Nationwide Interrupted Time Series Study
Impact of the “Class B Infectious Disease Class B Management” Policy on the Passenger Volume of Urban Rail Transit: A Nationwide Interrupted Time Series Study Open
Between 2019 and 2022, passenger volume on China’s urban rail transit system sharply declined due to strict COVID-19 control measures. On 8 January 2023, China implemented the “Class B infectious disease Class B management” policy, marking…
View article: Partial Discharge Characteristics Under Repetitive Pulsed Voltage Excitation Using BiLSTM-Based Networks
Partial Discharge Characteristics Under Repetitive Pulsed Voltage Excitation Using BiLSTM-Based Networks Open
This article presents a novel approach for detecting partial discharges (PDs) in motor winding insulation systems subjected to repetitive pulsed voltage excitation, a scenario that is fundamentally different from conventional sinusoidal ex…
View article: Ultra-High Energy Storage Density of Bsczt/Pvdf Composites Based on Egg-Like Ceramic Filler Driving Pvdf Phase Transformation
Ultra-High Energy Storage Density of Bsczt/Pvdf Composites Based on Egg-Like Ceramic Filler Driving Pvdf Phase Transformation Open
View article: Serpina3c deficiency promotes obesity-related hypertriglyceridemia and inflammation through activation of the Hif1α<i>-</i>glycolysis axis in adipose tissue
Serpina3c deficiency promotes obesity-related hypertriglyceridemia and inflammation through activation of the Hif1α<i>-</i>glycolysis axis in adipose tissue Open
Adipose tissue dysfunction leads to abnormal lipid metabolism and high inflammation levels. This research aims to explore the role of Serpina3c, which is highly expressed in adipocytes, in obesity-related hypertriglyceridemia and metaflamm…
View article: Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity
Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity Open
As the prevalence of obesity continues to rise globally, the research on adipocytes has attracted more and more attention. In the presence of nutrient overload, adipocytes are exposed to pressures such as hypoxia, inflammation, mechanical …
View article: Natural Mechanical Energy-Induced Porous Pani/(Ba0.85ca0.15)(Zr0.1ti0.9)O3/Pvdf Excellent Piezoelectric-Catalyzed Degradation of Dyes
Natural Mechanical Energy-Induced Porous Pani/(Ba0.85ca0.15)(Zr0.1ti0.9)O3/Pvdf Excellent Piezoelectric-Catalyzed Degradation of Dyes Open
View article: Optimization of thermal and light in underground atrium commercial spaces: a case study in Xuzhou, China
Optimization of thermal and light in underground atrium commercial spaces: a case study in Xuzhou, China Open
This paper studies the shape design strategy of underground atriums in cold regions based on climate adaptability. From the perspective of climate adaptability, by controlling the shape design parameters of the atrium, and taking the light…
View article: Overexpression of S100A1 in Osteosarcoma Inhibits Tumor Proliferation and Progression
Overexpression of S100A1 in Osteosarcoma Inhibits Tumor Proliferation and Progression Open
Background: Osteosarcoma is the most common primary malignant tumor of bone. Abnormal expression of S100A1 protein is closely related to the occurrence and development of malignant tumors. However, S100A1 in osteosarcoma has not been studi…
View article: Hyperadhesive von Willebrand Factor Promotes Extracellular Vesicle-Induced Angiogenesis
Hyperadhesive von Willebrand Factor Promotes Extracellular Vesicle-Induced Angiogenesis Open
View article: Anticoagulation targeting membrane-bound anionic phospholipids improves outcomes of traumatic brain injury in mice
Anticoagulation targeting membrane-bound anionic phospholipids improves outcomes of traumatic brain injury in mice Open
Severe traumatic brain injury (TBI) often causes an acute systemic hypercoagulable state that rapidly develops into consumptive coagulopathy. We have recently demonstrated that TBI-induced coagulopathy (TBI-IC) is initiated and disseminate…
View article: Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice
Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice Open
Traumatic brain injury-induced coagulopathy (TBI-IC) causes life-threatening secondary intracranial bleeding. Its pathogenesis differs mechanistically from that of coagulopathy arising from extracranial injuries and hemorrhagic shock, but …
View article: Comparison of Calcium Oxide and Calcium Peroxide Pretreatments of Wheat Straw for Improving Biohydrogen Production
Comparison of Calcium Oxide and Calcium Peroxide Pretreatments of Wheat Straw for Improving Biohydrogen Production Open
Wheat straw was pretreated with either CaO2 or CaO to improve biohydrogen production. Both CaO and CaO2 pretreatments improved the biodegradability of the wheat straw. CaO pretreatment raised the H2 yield b…
View article: Elevated microRNA‑145‑5p increases matrix metalloproteinase‑9 by activating the nuclear�factor‑κB pathway in rheumatoid arthritis
Elevated microRNA‑145‑5p increases matrix metalloproteinase‑9 by activating the nuclear�factor‑κB pathway in rheumatoid arthritis Open
The present study explored whether miR‑145‑5p can aggravate the development and progression of rheumatoid arthritis (RA) by regulating the expression of matrix metalloproteinases (MMPs). ELISAs, reverse transcription‑quantitative polymeras…
View article: Semaphorin 3A Contributes to Secondary Blood–Brain Barrier Damage After Traumatic Brain Injury
Semaphorin 3A Contributes to Secondary Blood–Brain Barrier Damage After Traumatic Brain Injury Open
Semaphorin 3A (SEMA3A) is a member of the Semaphorins family, a class of membrane-associated protein that participates in the construction of nerve networks. SEMA3A has been reported to affect vascular permeability previously, but its infl…
View article: Atorvastatin Protects Against Cerebral Aneurysmal Degenerative Pathology by Promoting Endothelial Progenitor Cells (EPC) Mobilization and Attenuating Vascular Deterioration in a Rat Model
Atorvastatin Protects Against Cerebral Aneurysmal Degenerative Pathology by Promoting Endothelial Progenitor Cells (EPC) Mobilization and Attenuating Vascular Deterioration in a Rat Model Open
BACKGROUND Endothelial injury is the early pathological change of cerebral aneurysm (CA) formation. In addition to its lipid-lowering activity, atorvastatin (ATR) also reportedly promotes vascular repair via mobilizing endothelial progenit…
View article: miR-145-5p Increases Osteoclast Numbers In Vitro and Aggravates Bone Erosion in Collagen-Induced Arthritis by Targeting Osteoprotegerin
miR-145-5p Increases Osteoclast Numbers In Vitro and Aggravates Bone Erosion in Collagen-Induced Arthritis by Targeting Osteoprotegerin Open
BACKGROUND Osteoprotegerin (OPG) inhibits bone resorption and binds with strong affinity to receptor activator of NF κB ligand (RANKL), thereby preventing RANKL from binding to its receptor RANK. Osteoclasts have documented effects on bone…
View article: Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury
Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury Open
View article: Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood–Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B
Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood–Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B Open
Our recent articles have reported that increased miR-21-5p in brain after traumatic brain injury (TBI) could improve the neurological outcome through alleviating blood-brain barrier (BBB) damage. miR-21-3p is another mature miRNA derived f…
View article: Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus
Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus Open
Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanisms underlying the effects of traumatic brain injury are not yet clear. Hippocampal excitability is strongly…
View article: Administration of Tauroursodeoxycholic Acid Attenuates Early Brain Injury via Akt Pathway Activation
Administration of Tauroursodeoxycholic Acid Attenuates Early Brain Injury via Akt Pathway Activation Open
Traumatic brain injury (TBI) is one of the leading causes of trauma-induced mortality and disability, and emerging studies have shown that endoplasmic reticulum (ER) stress plays an important role in the pathophysiology of TBI. Tauroursode…