Mengda Jiang
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View article: Glymphatic System Dysfunction in Thyroid Eye Disease Associated with Disease Activity and Duration
Glymphatic System Dysfunction in Thyroid Eye Disease Associated with Disease Activity and Duration Open
Glymphatic system dysfunction is evident in TED patients, with its extent influenced by disease activity and duration.
View article: TOM500: A Multi-Organ Annotated Orbital MRI Dataset for Thyroid Eye Disease
TOM500: A Multi-Organ Annotated Orbital MRI Dataset for Thyroid Eye Disease Open
This study presents TOM500, a comprehensive multi-organ annotated orbital magnetic resonance imaging (MRI) dataset. It includes clinical data, T2-weighted MRI scans, and corresponding segmentations from 500 patients with thyroid eye diseas…
View article: Optic nerve compression associated with visual cortex functional alteration in dysthyroid optic neuropathy: A combined orbital and brain imaging study
Optic nerve compression associated with visual cortex functional alteration in dysthyroid optic neuropathy: A combined orbital and brain imaging study Open
Aims To investigate the alterations of the optic nerve and visual cortex in dysthyroid optic neuropathy (DON), a subgroup of thyroid eye disease (TED). Methods Multiple orbital imaging biomarkers related to optic nerve compression and the …
View article: The insular cortex is not insular in thyroid eye disease: neuroimaging revelations of central–peripheral system interaction
The insular cortex is not insular in thyroid eye disease: neuroimaging revelations of central–peripheral system interaction Open
View article: Whole-orbit radiomics: machine learning-based multi- and fused- region radiomics signatures for intravenous glucocorticoid response prediction in thyroid eye disease
Whole-orbit radiomics: machine learning-based multi- and fused- region radiomics signatures for intravenous glucocorticoid response prediction in thyroid eye disease Open
Background Radiomics analysis of orbital magnetic resonance imaging (MRI) shows preliminary potential for intravenous glucocorticoid (IVGC) response prediction of thyroid eye disease (TED). The current region of interest segmentation conta…
View article: Rdinet: A Dynamic Mapping Model for Multimodal Feature Fusion for Treatment Response Prediction In Thyroid Eye Disease
Rdinet: A Dynamic Mapping Model for Multimodal Feature Fusion for Treatment Response Prediction In Thyroid Eye Disease Open
View article: Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss
Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss Open
Profound congenital sensorineural hearing loss (SNHL) prevents children from developing spoken language. Cochlear implantation and auditory brainstem implantation can provide partial hearing sensation, but language development outcomes can…
View article: Author response: Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss
Author response: Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Profound congenital s…
View article: Abnormal regional spontaneous neural activity and functional connectivity in thyroid-associated ophthalmopathy patients with different activity: a resting-state fMRI study
Abnormal regional spontaneous neural activity and functional connectivity in thyroid-associated ophthalmopathy patients with different activity: a resting-state fMRI study Open
Purpose We aimed to evaluate the spontaneous neuronal activity and functional connectivity pattern variations using resting-state functional magnetic resonance imaging (rs-fMRI) measures, such as amplitude of low-frequency fluctuation (ALF…
View article: T Cell Subsets are Associated with Clinical Activity and Efficacy of 4.5g Intravenous Glucocorticoid for Moderate-To-Severe Thyroid-Associated Ophthalmopathy
T Cell Subsets are Associated with Clinical Activity and Efficacy of 4.5g Intravenous Glucocorticoid for Moderate-To-Severe Thyroid-Associated Ophthalmopathy Open
Based on the findings of this study, we should monitor the peripheral blood T cell subsets for TAO, which could be helpful to timely judge the condition of clinical manifestation and effect of treatment for TAO patients. Multivariable pred…
View article: Postoperative hip center position is associated with gait symmetry in range of axial rotation in dysplasia patients after THA
Postoperative hip center position is associated with gait symmetry in range of axial rotation in dysplasia patients after THA Open
Background This study aimed to explore whether pre- or postoperative hip structures or surgical changes significantly influence hip range of motion (ROM) symmetry in patients with hip dysplasia during gait after total hip arthroplasty (THA…
View article: Impact of Peripheral Auditory Structure on the Development of Auditory-Language Network in Children with Profound Sensorineural Hearing Loss
Impact of Peripheral Auditory Structure on the Development of Auditory-Language Network in Children with Profound Sensorineural Hearing Loss Open
Profound congenital sensorineural hearing loss (SNHL) prevents children from developing spoken language. Cochlear implantation and auditory brainstem implantation can provide hearing sensation, but language development outcomes can vary, p…
View article: A Positive Response around 4.6 ms in Auditory Brainstem Response in Cochlear Nerve Deficiency Infants
A Positive Response around 4.6 ms in Auditory Brainstem Response in Cochlear Nerve Deficiency Infants Open
Objectives A positive response around 4.6 ms latency (IV’ wave) was observed at high intensity level in the ears which were always diagnosed with cochlear nerve deficiency (CND). This study is aimed to investigate the relationship between …
View article: Whole-Orbit Radiomics: Machine Learning-Based Multi- and Fused- Region Radiomics Signatures for Intravenous Glucocorticoid Response Prediction in Thyroid Eye Disease
Whole-Orbit Radiomics: Machine Learning-Based Multi- and Fused- Region Radiomics Signatures for Intravenous Glucocorticoid Response Prediction in Thyroid Eye Disease Open
View article: The combination of T2-mapping value of lacrimal gland and clinical indicators can improve the stage prediction of Graves’ ophthalmopathy compared to clinical activity scores
The combination of T2-mapping value of lacrimal gland and clinical indicators can improve the stage prediction of Graves’ ophthalmopathy compared to clinical activity scores Open
Purpose To explore radiological changes of the lacrimal gland (LG) in Graves’ ophthalmopathy (GO) and whether a combination of MRI parameters and clinical indicators can better predict individual clinical manifestation of GO compared to cl…
View article: A novel <scp><i>MPZL2</i></scp> c.<scp>68delC</scp> variant is associated with progressive hearing loss in Chinese population and literature review
A novel <span><i>MPZL2</i></span> c.<span>68delC</span> variant is associated with progressive hearing loss in Chinese population and literature review Open
Objective The aim of this study was to identify genetic etiology in two unrelated Chinese probands with progressive sensorineural hearing loss. Methods Two unrelated Chinese families were recruited. Genetic etiology was identified by targe…
View article: A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease
A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease Open
View article: Postoperative Hip Center Position Associated With the Range of Internal Rotation and Extension During Gait in Hip Dysplasia Patients After Total Hip Arthroplasty
Postoperative Hip Center Position Associated With the Range of Internal Rotation and Extension During Gait in Hip Dysplasia Patients After Total Hip Arthroplasty Open
Background: Total hip arthroplasty (THA) for hip dysplasia patients is sometimes complex and compromises pathomorphological changes in these patients. However, it remains unclear whether it is preoperative deformities or postoperative stru…
View article: Genetic findings of Sanger and nanopore single-molecule sequencing in patients with X-linked hearing loss and incomplete partition type III
Genetic findings of Sanger and nanopore single-molecule sequencing in patients with X-linked hearing loss and incomplete partition type III Open
View article: Imaging of the Peptide Functionalized Met-Targeting Probe Using T1 Mapping in Detecting Marginal Infiltration of GBM
Imaging of the Peptide Functionalized Met-Targeting Probe Using T1 Mapping in Detecting Marginal Infiltration of GBM Open
View article: Robot-Assisted Electrode Array Insertion Becomes Available in Pediatric Cochlear Implant Recipients: First Report and an Intra-Individual Study
Robot-Assisted Electrode Array Insertion Becomes Available in Pediatric Cochlear Implant Recipients: First Report and an Intra-Individual Study Open
Background: As an advanced surgical technique to reduce trauma to the inner ear, robot-assisted electrode array (EA) insertion has been applied in adult cochlear implantation (CI) and was approved as a safe surgical procedure that could re…
View article: Genetic Findings of Sanger and Nanopore Single-Molecule Sequencing in Patients with X-Linked Hearing Loss and Incomplete Partition Type III
Genetic Findings of Sanger and Nanopore Single-Molecule Sequencing in Patients with X-Linked Hearing Loss and Incomplete Partition Type III Open
BackgroundPOU3F4 is the causative gene for X-linked deafness-2 (DFNX2), characterized by incomplete partition type III (IP-III) malformation of the inner ear. The aim of this study was to investigate the clinical characteristics and molecu…
View article: Influence of 4‐week or 12‐week glucocorticoid treatment on metabolic changes in patients with active moderate‐to‐severe thyroid‐associated ophthalmopathy
Influence of 4‐week or 12‐week glucocorticoid treatment on metabolic changes in patients with active moderate‐to‐severe thyroid‐associated ophthalmopathy Open
Thyroid‐associated ophthalmopathy (TAO) is a serious, progressive, vision‐threatening and difficult‐to‐treat organ‐specific autoimmune disease. The course, therapeutic effects and prognosis of moderate to severe TAO vary greatly. High‐dose…
View article: Detection of active and inactive phases of thyroid-associated ophthalmopathy using deep convolutional neural network
Detection of active and inactive phases of thyroid-associated ophthalmopathy using deep convolutional neural network Open
View article: Clinical and imaging features of intraosseous arteriovenous malformations in jaws: a 15-year experience of single centre
Clinical and imaging features of intraosseous arteriovenous malformations in jaws: a 15-year experience of single centre Open
View article: Selection and application of coils in temporomandibular joint MRI
Selection and application of coils in temporomandibular joint MRI Open
Objective: To compare and evaluate the signal-to-noise ratio (SNR) and the contrast-to-noise ratio (CNR) values between a 15-channel phased array head coil and 6-channel dS Flex M surface coil in the MRI of temporomandibular joint. Methods…
View article: Effects of region of interest sizes on apparent diffusion coefficient measurements of pleomorphic adenoma, Warthin tumor, and normal parotid parenchyma
Effects of region of interest sizes on apparent diffusion coefficient measurements of pleomorphic adenoma, Warthin tumor, and normal parotid parenchyma Open
The effect of ROI size on ADC measurements could be excluded from the differentiation of PA, WT, and normal parotid parenchyma. Homogeneity index was a useful parameter in discriminating between the three groups.
View article: The value of scintigraphy, computed tomography, magnetic resonance imaging, and single-photon emission computed tomography/computed tomography for the diagnosis of ectopic thyroid in the head and neck
The value of scintigraphy, computed tomography, magnetic resonance imaging, and single-photon emission computed tomography/computed tomography for the diagnosis of ectopic thyroid in the head and neck Open
Because of its rarity, the exact imaging features of ectopic thyroid are poorly known.To analyze the value of scintigraphy, computed tomography (CT), magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT)/…
View article: Palatal lesions: discriminative value of conventional MRI and diffusion weighted imaging
Palatal lesions: discriminative value of conventional MRI and diffusion weighted imaging Open
Combination of conventional MRI and ADC scores could increase the ability to differentiate malignant from benign palatal lesions, with a sensitivity of 100% and specificity of 75.0%, although without statistical significance.