Mengge Chen
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View article: Macrophage migration inhibitory factor of zoonotic Giardia duodenalis triggers TLR4-MAPK/AKT/NLRP3 pathways to regulate inflammatory response
Macrophage migration inhibitory factor of zoonotic Giardia duodenalis triggers TLR4-MAPK/AKT/NLRP3 pathways to regulate inflammatory response Open
Summary: Giardia duodenalis is an important zoonotic protozoan that has a significant negative impact on public health worldwide. G. duodenalis macrophage migration inhibitory factor (GdMIF) has close similarity with mammalian MIF, yet its…
View article: β-Giardin as an Immunomagnetic Enrichment Target for Multi-Host Detection of Giardia duodenalis Cysts
β-Giardin as an Immunomagnetic Enrichment Target for Multi-Host Detection of Giardia duodenalis Cysts Open
Giardiasis is a globally prevalent waterborne zoonosis. Rapid enrichment and detection technologies for this disease are essential. Cyst outer wall proteins are ideal targets for the enrichment and detection of cysts in the environment, bu…
View article: TLR2-FADS1-cPLA2-arachidonic acid axis drives necroptosis to restrict zoonotic Cryptosporidium parvum infection and mitigate intestinal injury
TLR2-FADS1-cPLA2-arachidonic acid axis drives necroptosis to restrict zoonotic Cryptosporidium parvum infection and mitigate intestinal injury Open
Cryptosporidiosis is a globally prevalent diarrheal disease caused by Cryptosporidium parvum (C. parvum), yet effective therapies remain lacking. Here, we uncover a host-protective mechanism wherein C. parvum infection activated necroptosi…
View article: Immunization with the NcMYR1 gene knockout strain effectively protected C57BL/6 mice and their pups against the <i>Neospora caninum</i> challenge
Immunization with the NcMYR1 gene knockout strain effectively protected C57BL/6 mice and their pups against the <i>Neospora caninum</i> challenge Open
Neospora caninum is an important protozoan parasite that causes abortion in cattle and nervous system dysfunction in dogs. No effective drugs and vaccines for neosporosis are available. Further elucidation of proteins related to N. caninum…
View article: Isolation and characterization of Salmonella enteritidis bacteriophage Salmp-p7 isolated from slaughterhouse effluent and its application in food
Isolation and characterization of Salmonella enteritidis bacteriophage Salmp-p7 isolated from slaughterhouse effluent and its application in food Open
Salmonella enteritidis is one of the most common pathogens that cause foodborne outbreaks and food spoilage, which seriously threatens human health. In this study, Salmonella enteritidis bacteriophage Salmp-p7 was isolated and characterize…
View article: Single‐cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism‐related mechanisms
Single‐cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism‐related mechanisms Open
Aim The main focus of this study is to explore the molecular mechanism of IRF7 regulation on RPS18 transcription in M1‐type macrophages in pancreatic adenocarcinoma (PAAD) tissue, as well as the transfer of RPS18 by IRF7 via exosomes to PA…
View article: Three Cases of Gastric Adenocarcinoma with Enteroblstic Differentiation
Three Cases of Gastric Adenocarcinoma with Enteroblstic Differentiation Open
目的:胃原発胎児消化管類似癌(gastric adenocarcinoma with enteroblastic differentiation:GACED)は,胎生初期の消化管上皮に類似した淡明な円柱細胞が管状・乳頭状あるいは充実性増殖を示す胃癌で,胃癌取扱い規約では特殊型のその他の癌に分類される稀な病態である.脈管侵襲が高度で予後不良とされているが,その臨床的特徴は十分に解明されていない.今回われわれは,根治術を施行したGACEDの3例を経験したので報告する.症例:症例…
View article: Characterization of Procollagen-lysine, 2-oxoglutarate 5-dioxygenases as Therapeutic Targets in a Pan-Cancer Study
Characterization of Procollagen-lysine, 2-oxoglutarate 5-dioxygenases as Therapeutic Targets in a Pan-Cancer Study Open
Background Certain members of the Procollagen-lysine 2-oxyglutarate 5-dioxygenase (PLOD) family have been identified to play a role in tumor metastasis and progression. Materials & Methods The association between PLOD expression and overal…
View article: MiR-455-3p inhibits gastric cancer progression by repressing Wnt/β-catenin signaling through binding to ARMC8
MiR-455-3p inhibits gastric cancer progression by repressing Wnt/β-catenin signaling through binding to ARMC8 Open
Background Globally, gastric cancer (GC) is one of the world’s most widespread malignancies, with persistent high mortality and morbidity rates. Increasing evidence now suggests that microRNAs (miRNAs) participate in many biological proces…
View article: MT1X is an oncogene and indicates prognosis in ccRCC
MT1X is an oncogene and indicates prognosis in ccRCC Open
The metallothionein 1 (MT1) family was previously shown to be involved in metal ion homeostasis, DNA damage, oxidative stress, and carcinogenesis. Our team’s previous study showed that MT1X is most closely associated with ccRCC. However, i…
View article: Neospora caninum Evades Immunity via Inducing Host Cell Mitophagy to Inhibit Production of Proinflammatory Cytokines in a ROS-Dependent Manner
Neospora caninum Evades Immunity via Inducing Host Cell Mitophagy to Inhibit Production of Proinflammatory Cytokines in a ROS-Dependent Manner Open
Neospora caninum is an intracellular protozoan that mainly infects cattle to cause abortion and significant economic losses worldwide. A better understanding of the immune evasion mechanisms of N. caninum could help to search for an effect…
View article: Luxury in Emerging Markets: An Investigation of the Role of Subjective Social Class and Conspicuous Consumption
Luxury in Emerging Markets: An Investigation of the Role of Subjective Social Class and Conspicuous Consumption Open
This study is based on the relationship between the anxiety of social groups (especially the young) in today’s social environment and the increasingly younger and more sociable consumer groups in China’s luxury market. In combination with …
View article: Peer Review #2 of "CRYAB predicts clinical prognosis and is associated with immunocyte infiltration in colorectal cancer (v0.2)"
Peer Review #2 of "CRYAB predicts clinical prognosis and is associated with immunocyte infiltration in colorectal cancer (v0.2)" Open
Background αB-Crystallin (CRYAB) is differentially expressed in various tumors.However, the correlation between CRYAB and immune cell infiltration in colorectal cancer remains unclear.Materials & Methods CRYAB expression was examined in co…
View article: CRYAB predicts clinical prognosis and is associated with immunocyte infiltration in colorectal cancer
CRYAB predicts clinical prognosis and is associated with immunocyte infiltration in colorectal cancer Open
Background αB-Crystallin (CRYAB) is differentially expressed in various tumors. However, the correlation between CRYAB and immune cell infiltration in colorectal cancer (CRC) remains unclear. Materials & Methods Kaplan–Meier survival curve…
View article: Corrigendum: Effectiveness of Physical Activity Intervention on ADHD Symptoms: A Systematic Review and Meta-Analysis
Corrigendum: Effectiveness of Physical Activity Intervention on ADHD Symptoms: A Systematic Review and Meta-Analysis Open
[This corrects the article DOI: 10.3389/fpsyt.2021.706625.].
View article: Effectiveness of Physical Activity Intervention on ADHD Symptoms: A Systematic Review and Meta-Analysis
Effectiveness of Physical Activity Intervention on ADHD Symptoms: A Systematic Review and Meta-Analysis Open
Objective: To assess the effectiveness of physical activity (PA) intervention on attention-deficit/hyperactivity disorder (ADHD)-related symptoms. Method: Studies that investigated PA intervention for ADHD-related symptoms were identified …
View article: AEBP1 Predicts Clinical Prognosis and is Associated with Immunocyte Infiltration in Gastric Cancer
AEBP1 Predicts Clinical Prognosis and is Associated with Immunocyte Infiltration in Gastric Cancer Open
AEBP1 is differentially expressed in various tumors. However, the correlation between AEBP1 and immune cell infiltration in gastric cancer remains unclear. Kaplan-Meier survival curves were used to evaluate the relationship between AEBP1 e…
View article: Overexpressed pseudogene MT1L associated with tumor immune infiltrates and indicates a worse prognosis in BLCA
Overexpressed pseudogene MT1L associated with tumor immune infiltrates and indicates a worse prognosis in BLCA Open
Background BLCA is a common cancer worldwide, and it is both aggressive and fatal. Immunotherapy (ICT) has achieved an excellent curative effect in BLCA; however, only some BLCA patients can benefit from ICT. MT1L is a pseudogene, and a pr…
View article: A patient with a desmoid tumor in the 1st intercostal space who received adjuvant radiotherapy
A patient with a desmoid tumor in the 1st intercostal space who received adjuvant radiotherapy Open
症例は67歳男性．右胸部重苦感と右上腕に放散する疼痛を主訴に当院を受診した．胸部CTで右第一肋間に境界明瞭，辺縁平滑な充実性腫瘤を認め，胸腔鏡下腫瘍摘出術を行った．術後の病理組織診断はデスモイド腫瘍であり，術後症状は消失した．切除断端陽性の可能性が高いと判断し，再発予防のため術後60 Gyの補助放射線治療を行った．デスモイド腫瘍は組織学的には良性腫瘍であるが局所浸潤が強く，局所再発が高い傾向にある．特に高位肋間に発生したデスモイド腫瘍の場合，周囲に重要臓器が存在することや術…
View article: Overexpressed Pseudogene MT1L Associated with Tumor Immune Infiltrates and Indicates a Worse Prognosis in BLCA
Overexpressed Pseudogene MT1L Associated with Tumor Immune Infiltrates and Indicates a Worse Prognosis in BLCA Open
Background BLCA is common cancer worldwide, aggressive, and fatal. Immunotherapy (ICT) has achieved an excellent curative effect in BLCA; however, only part of these patients can benefit from ICT treatment. MT1L belongs to pseudogene, and …
View article: Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in<i> Vivo</i>
Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in<i> Vivo</i> Open
Loco-regional recurrence of nasopharyngeal carcinoma (NPC) after radiation therapy is one of the main types of treatment failure. This study is aimed to explore the possible causes of inside-field recurrence of NPC patients in order to dev…
View article: Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis
Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis Open
Zinc pyrithione (ZPT) is widely used as an antimicrobial. Zinc is a necessary trace element of the human whose homeostasis associated with several cancers. However, the anticancer effect of increased Zinc in ovarian cancer is still unclear…
View article: Deep convolutional neural network application on rooftop detection for aerial image
Deep convolutional neural network application on rooftop detection for aerial image Open
As one of the most destructive disasters in the world, earthquake causes death, injuries, destruction and enormous damage to the affected area. It is significant to detect buildings after an earthquake in response to reconstruction and dam…
View article: Building Detection from Very High Resolution Remotely Sensed Imagery Using Deep Neural Networks
Building Detection from Very High Resolution Remotely Sensed Imagery Using Deep Neural Networks Open
The past decades have witnessed a significant change in human societies with a fast pace and rapid urbanization. The boom of urbanization is contributed by the influx of people to the urban area and comes with building construction and dec…
View article: Risk Factors Analysis of Pathologically Confirmed Cervical Lymph Nodes Metastasis in Oral Squamous Cell Carcinoma Patients with Clinically Negative Cervical Lymph Node: Results from a Cancer Center of Central China
Risk Factors Analysis of Pathologically Confirmed Cervical Lymph Nodes Metastasis in Oral Squamous Cell Carcinoma Patients with Clinically Negative Cervical Lymph Node: Results from a Cancer Center of Central China Open
Objective: To explore the risk factors of cervical lymph node metastasis in oral squamous cell carcinoma (OSCC) patients with clinical negative cervical lymph nodes(cN0) and provide a reference for clinical treatment. Methods: The clinical…
View article: Characterization of ferulic acid and its derivatives on the aggregation of α-synuclein
Characterization of ferulic acid and its derivatives on the aggregation of α-synuclein Open
Background: α-synuclein(α-Syn) is the major component of Lewy body which appears in α-synucleinopathies like Parkinson's disease, Dementia with Lewy bodies and multiple system atrophy. The aggregates and amyloid fibril formation of α-Syn a…
View article: Application of new enhanced medium in indirect antiglobulin test by gel method
Application of new enhanced medium in indirect antiglobulin test by gel method Open
The objective of this study was to explore the efficacy of a new enhanced medium in indirect antiglobulin test by optimized gel method. Anti-IgG+ C3d and anti-IgG antiglobulin gel cards, and samples from three blood group systems: Rh, Kidd…
View article: [Association between the ALK Gene Status and the Efficacy of First-line
Pemetrexed Chemotherapy in Patients with Advanced Lung Adenocarcinoma].
[Association between the ALK Gene Status and the Efficacy of First-line
Pemetrexed Chemotherapy in Patients with Advanced Lung Adenocarcinoma]. Open
ALK-positive lung adenocarcinoma patients with first-line pemetrexed-based chemotherapy have greater clinical benefit than ALK-negative patients.