Minfeng Xiao
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View article: Exploring ceRNA mechanisms in COVID-19 mRNA vaccine-induced myocarditis: implications for future vaccine design
Exploring ceRNA mechanisms in COVID-19 mRNA vaccine-induced myocarditis: implications for future vaccine design Open
Introduction The emergence of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitated the rapid development of effective vaccines, with mRNA vaccines demonstrating high effica…
View article: Optimal Power Flow of Unbalanced Distribution Networks Using a Novel Shrinking Net Algorithm
Optimal Power Flow of Unbalanced Distribution Networks Using a Novel Shrinking Net Algorithm Open
The increasing penetration of distributed energy resources (DERs) in unbalanced distribution networks presents significant challenges for optimal operation, particularly concerning power loss minimization and voltage regulation. This paper…
View article: Non-solution power flow diagnosis method for AC/DC hybrid power grid based on topology-aware graph neural network
Non-solution power flow diagnosis method for AC/DC hybrid power grid based on topology-aware graph neural network Open
With the continuous evolution of power grids, the issue of power flow unsolvability in hybrid AC–DC grids, arising from topological changes, abrupt load variations, or control failures, has become increasingly prominent. To overcome the bl…
View article: MoEPH: an adaptive fusion-based LLM for predicting phage-host interactions in health informatics
MoEPH: an adaptive fusion-based LLM for predicting phage-host interactions in health informatics Open
Phage-host interaction prediction plays a crucial role in the development of phage therapy, particularly in combating antimicrobial resistance (AMR). Current in silico models often suffer from limited generalizability and low interpretabil…
View article: Genome-Wide Identification, Molecular Evolution, and Abiotic Stress-Responsive Regulation of Cupin Superfamily Genes in Rice (Oryza sativa L.)
Genome-Wide Identification, Molecular Evolution, and Abiotic Stress-Responsive Regulation of Cupin Superfamily Genes in Rice (Oryza sativa L.) Open
The Cupin superfamily, characterized by a conserved β-barrel structure, plays crucial roles in plant growth, development, and stress responses. However, comprehensive analyses of this gene family in rice remains limited. Here, we performed…
View article: From nature’s deadly strike to safety protection: Mantis shrimp-inspired ultrafast energy transformation for smart surveillance
From nature’s deadly strike to safety protection: Mantis shrimp-inspired ultrafast energy transformation for smart surveillance Open
View article: Genome-wide identification of GATA family genes in sweet potato (Ipomoea batatas L.) and their expression patterns under abiotic stress
Genome-wide identification of GATA family genes in sweet potato (Ipomoea batatas L.) and their expression patterns under abiotic stress Open
GATAs, a type of zinc finger protein transcription factors, can bind to DNA regulatory regions to control the expression of target genes, thereby affecting plant growth and development under normal conditions or environmental stress. Howev…
View article: Enhancing Strain-level Phage-Host Prediction through Experimentally Vali-dated Negatives and Feature Optimization Strategies
Enhancing Strain-level Phage-Host Prediction through Experimentally Vali-dated Negatives and Feature Optimization Strategies Open
Accurate prediction of phage-host interactions at the strain level is critical for understanding microbial ecology and for developing phage-based therapeutics. However, existing models are limited by the lack of experimentally validated ne…
View article: High Impedance Fault Line Detection Based on Current Traveling Wave Spectrum Symmetry Driving for New Distribution Network
High Impedance Fault Line Detection Based on Current Traveling Wave Spectrum Symmetry Driving for New Distribution Network Open
Challenges are brought to high impedance fault (HIF) line selection in traditional distribution networks by the fault signals with short windows and weak characteristics provided by new energy power sources. A new method driven by the symm…
View article: Exploration of the feasibility of clinical application of phage treatment for multidrug-resistant <i>Serratia marcescens</i> -induced pulmonary infection
Exploration of the feasibility of clinical application of phage treatment for multidrug-resistant <i>Serratia marcescens</i> -induced pulmonary infection Open
Serratia marcescens (S. marcescens) commonly induces refractory infection due to its multidrug-resistant nature. To date, there have been no reports on the application of phage treatment for S. marcescens infection. Th…
View article: A roadmap of isolating and investigating bacteriophage infecting human gut anaerobes
A roadmap of isolating and investigating bacteriophage infecting human gut anaerobes Open
Bacteriophages, viruses that infect bacteria, play a crucial role in manipulating the gut microbiome, with implications for human health and disease. Despite the vast amount of data available on the human gut virome, the number of cultured…
View article: Preparation of mechano-nanoswitches for ultrasound-controlled drug activation
Preparation of mechano-nanoswitches for ultrasound-controlled drug activation Open
Chemotherapy is often hindered by issues associated with deficient drug selectivity and ineluctable toxic effects. The emerging realm of mechanochemistry has demonstrated significant promise in precise drug activation by using ultrasound-i…
View article: Diversity and phage sensitivity to phages of porcine enterotoxigenic <i>Escherichia coli</i>
Diversity and phage sensitivity to phages of porcine enterotoxigenic <i>Escherichia coli</i> Open
Enterotoxigenic Escherichia coli (ETEC) is a diverse and poorly characterized E. coli pathotype that causes diarrhea in humans and animals. Phages have been proposed for the veterinary biocontrol of ETEC, but effective solutions require un…
View article: Substantial viral diversity in bats and rodents from East Africa: insights into evolution, recombination, and cocirculation
Substantial viral diversity in bats and rodents from East Africa: insights into evolution, recombination, and cocirculation Open
View article: Characterization of a novel genus of jumbo phages and their application in wastewater treatment
Characterization of a novel genus of jumbo phages and their application in wastewater treatment Open
View article: PhaGAA: an integrated web server platform for phage genome annotation and analysis
PhaGAA: an integrated web server platform for phage genome annotation and analysis Open
Motivation Phage genome annotation plays a key role in the design of phage therapy. To date, there have been various genome annotation tools for phages, but most of these tools focus on mono-functional annotation and have complex operation…
View article: Vertical and horizontal gene transfer tradeoffs direct plasmid fitness
Vertical and horizontal gene transfer tradeoffs direct plasmid fitness Open
View article: Harnessing stepping-stone hosts to engineer, select, and reboot synthetic bacteriophages in one pot
Harnessing stepping-stone hosts to engineer, select, and reboot synthetic bacteriophages in one pot Open
Advances in synthetic genomics have led to a great demand for genetic manipulation. Trimming any process to simplify and accelerate streamlining of genetic code into life holds great promise for synthesizing and studying organisms. Here, w…
View article: Genomic characterization of four novel bacteriophages infecting the clinical pathogen <i>Klebsiella pneumoniae</i>
Genomic characterization of four novel bacteriophages infecting the clinical pathogen <i>Klebsiella pneumoniae</i> Open
Bacteriophages are an invaluable source of novel genetic diversity. Sequencing of phage genomes can reveal new proteins with potential uses as biotechnological and medical tools, and help unravel the diversity of biological mechanisms empl…
View article: Genomic characterization of four novel bacteriophages infecting the clinical pathogen<i>Klebsiella pneumoniae</i>
Genomic characterization of four novel bacteriophages infecting the clinical pathogen<i>Klebsiella pneumoniae</i> Open
Bacteriophages are an invaluable source of novel genetic diversity. Sequencing of phage genomes can reveal new proteins with potential uses as biotechnological and medical tools, and help unravel the diversity of biological mechanisms empl…
View article: Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients
Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients Open
View article: Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2
Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 Open
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across hous…
View article: Phylogenetic analysis of 48 early sars-cov-2 genomes
Phylogenetic analysis of 48 early sars-cov-2 genomes Open
Background: First isolated in December 2019, SARS-CoV-2 is the agent responsible for the ongoing breakout of COVID-19. Method: We curated an assembly of the first 48 full-length SARS-CoV-2 genomes isolated and sequenced across the world an…
View article: Additional file 1 of Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients
Additional file 1 of Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients Open
Additional file 1: Table S1. Summary of clinical samples and patients with COVID-19. Table S2. List of public genomes used for analysis. Table S3. Allele frequency of iSNVs detected from metatranscriptomic and/or hybrid capture data. Table…
View article: Genetic signatures for lineage/sublineage classification of HPV16, 18, 52 and 58 variants
Genetic signatures for lineage/sublineage classification of HPV16, 18, 52 and 58 variants Open
Increasing evidences indicate that high-risk HPV variants are heterogeneous in carcinogenicity and ethnic dispersion. In this work, we identified genetic signatures for convenient determination of lineage/sublineage of HPV16, 18, 52 and 58…
View article: Temporal encoding of bacterial identity and traits in growth dynamics
Temporal encoding of bacterial identity and traits in growth dynamics Open
Significance Microbiology has traditionally been defined by the study of the phenotypic traits of microorganisms. While some traits can be easily explained with a direct genetic basis, most are a result of complex interactions between the …
View article: Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples
Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples Open
View article: Intra-host Variation and Evolutionary Dynamics of SARS-CoV-2 Population in COVID-19 Patients
Intra-host Variation and Evolutionary Dynamics of SARS-CoV-2 Population in COVID-19 Patients Open
As of middle May 2020, the causative agent of COVID-19, SARS-CoV-2, has infected over 4 million people with more than 300 thousand death as official reports 1,2 . The key to understanding the biology and virus-host interactions of SARS-CoV…
View article: Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples
Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples Open
COVID-19 has caused a major epidemic worldwide, however, much is yet to be known about the epidemiology and evolution of the virus. One reason is that the challenges underneath sequencing HCoV-19 directly from clinical samples have not bee…
View article: Environmental and genetic determinants of plasmid mobility in pathogenic <i>Escherichia coli</i>
Environmental and genetic determinants of plasmid mobility in pathogenic <i>Escherichia coli</i> Open
Integrating genomics with growth-based phenotyping reveals divergent roles of antibiotics and incompatibility in plasmid mobility.