Meng‐Jiang He
YOU?
Author Swipe
View article: Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas
Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas Open
View article: Validation of a clinical scoring model and proposal of a classification system to guide endoscopic resection strategies for cardial submucosal tumors
Validation of a clinical scoring model and proposal of a classification system to guide endoscopic resection strategies for cardial submucosal tumors Open
Background and aims: A scoring model was proposed to support endoscopic decision-making for cardial submucosal tumors (SMTs). The aim of this study is to perform a multicenter validation of the clinical scoring model and to introduce a new…
View article: Sex-specific association of visceral and abdominal subcutaneous adipose tissue with gastroesophageal reflux disease: a large-scale perspective cohort study
Sex-specific association of visceral and abdominal subcutaneous adipose tissue with gastroesophageal reflux disease: a large-scale perspective cohort study Open
View article: Exploration of multi-omics liquid biopsy approaches for multi-cancer early detection: The PROMISE study
Exploration of multi-omics liquid biopsy approaches for multi-cancer early detection: The PROMISE study Open
View article: GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing
GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing Open
View article: Expert-AI Collaborative Training for Novice Endoscopists: A Path to Enhanced Efficiency
Expert-AI Collaborative Training for Novice Endoscopists: A Path to Enhanced Efficiency Open
Background: Esophagogastroduodenoscopy (EGD) is essential for diagnosing upper gastrointestinal disorders. Traditional training for novice endoscopists is often inefficient and inconsistent. This study evaluates the effectiveness of an AI-…
View article: Efficacy and safety of endoscopic intraperitoneal subserosal dissection for gastric submucosal tumors with extraluminal growth pattern
Efficacy and safety of endoscopic intraperitoneal subserosal dissection for gastric submucosal tumors with extraluminal growth pattern Open
Endoscopic intraperitoneal subserosal dissection (EISD) has been reported to be a promising modified tunneling technique for gastric submucosal tumors (SMTs) with a predominantly extraluminal growth pattern. We evaluated the safety and eff…
View article: Endoscopic transcecal appendectomy for a laterally spreading tumor of the appendiceal stump
Endoscopic transcecal appendectomy for a laterally spreading tumor of the appendiceal stump Open
View article: Association of maternal smoking, breastfeeding, and multiple birth with irritable bowel syndrome in older adults: a UK Biobank cohort study
Association of maternal smoking, breastfeeding, and multiple birth with irritable bowel syndrome in older adults: a UK Biobank cohort study Open
Background We aimed to investigate associations between three perinatal early-life factors and the risk of irritable bowel syndrome (IBS) in middle-aged and elderly people by using data from UK Biobank. Methods This is a population-based c…
View article: Pan-gastrointestinal adenocarcinoma analysis uncovers the prognostic and immune correlates of ferroptosis-related genes
Pan-gastrointestinal adenocarcinoma analysis uncovers the prognostic and immune correlates of ferroptosis-related genes Open
Our findings delineated the clinical relevance of ferroptosis-related genes in GIACs and demonstrated the potential utility of the ferroptosis-score in predicting prognosis and immunotherapy effectiveness.
View article: Management of recurrence after peroral endoscopic myotomy and submucosal tunneling endoscopic septum division
Management of recurrence after peroral endoscopic myotomy and submucosal tunneling endoscopic septum division Open
Achalasia sometimes coexists with esophageal diverticulum [1], and the combination of peroral endoscopic myotomy (POEM) and submucosal tunneling endoscopic septum division (STESD) is efficient and safe for relieving the symptom [2] [3]. Ho…
View article: A longitudinal study of endoscopic naso-leakage negative pressure drainage for anastomotic leak after esophagectomy
A longitudinal study of endoscopic naso-leakage negative pressure drainage for anastomotic leak after esophagectomy Open
Background and aims Postoperative anastomotic leak is a threatening complication after esophagectomy. This study aims to evaluate the efficacy of endoscopic naso-leakage negative pressure drainage for anastomotic leak by longitudinal analy…
View article: A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia
A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia Open
Achalasia is a rare motility disorder of the esophagus caused by the gradual degeneration of myenteric neurons. Immune-mediated ganglionitis has been proposed to underlie the loss of myenteric neurons. Here, we measure the immune cell tran…
View article: SINGLE-CELL TRANSCRIPTOMIC ANALYSIS DECIPHERS KEY TRANSITIONAL SIGNATURES ASSOCIATED WITH ONCOGENIC EVOLUTION IN HUMAN INTRAMUCOSAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA
SINGLE-CELL TRANSCRIPTOMIC ANALYSIS DECIPHERS KEY TRANSITIONAL SIGNATURES ASSOCIATED WITH ONCOGENIC EVOLUTION IN HUMAN INTRAMUCOSAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA Open
View article: SINGLE-CELL TRANSCRIPTOMIC ANALYSIS DECIPHERS KEY TRANSITIONAL SIGNATURES ASSOCIATED WITH ONCOGENIC EVOLUTION IN HUMAN INTRAMUCOSAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA
SINGLE-CELL TRANSCRIPTOMIC ANALYSIS DECIPHERS KEY TRANSITIONAL SIGNATURES ASSOCIATED WITH ONCOGENIC EVOLUTION IN HUMAN INTRAMUCOSAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA Open
View article: Single‐cell transcriptomic analysis deciphers key transitional signatures associated with oncogenic evolution in human intramucosal oesophageal squamous cell carcinoma
Single‐cell transcriptomic analysis deciphers key transitional signatures associated with oncogenic evolution in human intramucosal oesophageal squamous cell carcinoma Open
Background and aims The early diagnosis and intervention of oesophageal squamous cell carcinoma (ESCC) are particularly important because of the lack of effective therapies and poor prognosis. Comprehensive research on early ESCC at the si…
View article: Publication trends of peroral endoscopic myotomy during 2010–2022: a bibliometric analysis
Publication trends of peroral endoscopic myotomy during 2010–2022: a bibliometric analysis Open
Researchers from the United States, China, and Japan have published the most articles in the field of POEM research, but there was a disparity between the quantity and quality of publications. Research of management and POEM-derived novel …
View article: 212. LAPARO-GASTROSCOPIC ESOPHAGECTOMY: A RETROSPECTIVE STUDY OF A PIONEER CASE SERIES
212. LAPARO-GASTROSCOPIC ESOPHAGECTOMY: A RETROSPECTIVE STUDY OF A PIONEER CASE SERIES Open
Transcervical gastroscopic esophagectomy pioneered the gastroscope from intraluminal to extraluminal dissection for esophageal cancer. Its integration with laparoscopic gastric conduit formation, known as laparo-gastroscopic esophagectomy …
View article: Single-cell transcriptomic analysis deciphers key transitional signatures associated with oncogenic evolution in human intramucosal esophageal squamous cell carcinoma
Single-cell transcriptomic analysis deciphers key transitional signatures associated with oncogenic evolution in human intramucosal esophageal squamous cell carcinoma Open
Background: The early diagnosis and intervention of esophageal squamous cell carcinoma (ESCC) is particularly important due to poor prognosis and the lack of effective therapies. This study aims to systematically describe the cellular atla…
View article: Transcervical versus transthoracic minimally invasive esophagectomy: a randomized and controlled trial protocol
Transcervical versus transthoracic minimally invasive esophagectomy: a randomized and controlled trial protocol Open
This study is registered in Chinese Clinical Trial Registry (ChiCTR2200055312) with the name of 'Transcervical versus Transthoracic Minimally Invasive Esophagectomy: A Randomized and Controlled Trial' on January 6, 2022. Details can be fou…
View article: Utility of endoscopic ultrasound-guided fine-needle aspiration in pancreatic cancer patients who failed to obtain a pathological diagnosis in surgical exploration
Utility of endoscopic ultrasound-guided fine-needle aspiration in pancreatic cancer patients who failed to obtain a pathological diagnosis in surgical exploration Open
Intraoperative biopsy is the first choice diagnostic modality for unresectable pancreatic neoplasms. However, for patients who fail to obtain a pathological diagnosis in surgical exploration, EUS-FNA is still worth an attempt.
View article: Notch Pathway Defines an Aggressive and Immune-Suppressive Phenotype Associated with Checkpoint Inhibitor Resistance in Pan-Gastrointestinal Adenocarcinomas
Notch Pathway Defines an Aggressive and Immune-Suppressive Phenotype Associated with Checkpoint Inhibitor Resistance in Pan-Gastrointestinal Adenocarcinomas Open
View article: Endoscopic submucosal dissection for an early-stage neuroendocrine carcinoma composited with squamous cell dysplasia
Endoscopic submucosal dissection for an early-stage neuroendocrine carcinoma composited with squamous cell dysplasia Open
A 51-year-old man complained of dysphagia for 2 months. A reddish and rough lesion was found 25 cm from the incisor under esophagogastroduodenoscopy (EGD) ([Fig. 1 a]). Pathological assessment of the biopsy indicated neuroendocrine carcino…
View article: Novel technique for treating intussuscepted intestinal Meckel’s diverticulum: enteroscopic intestinal diverticulum dissection (EIDD)
Novel technique for treating intussuscepted intestinal Meckel’s diverticulum: enteroscopic intestinal diverticulum dissection (EIDD) Open
Meckel’s diverticulum is a well-described anomaly of the small intestine caused by the incomplete closure of the omphalomesenteric or vitelline duct. It generally does not cause any symptoms [1]. Treatment is usually performed for complica…
View article: Endoscopic intraperitoneal subserosal dissection combined with endoscopic ultrasonography-assisted location of an extraluminally growing stromal tumor
Endoscopic intraperitoneal subserosal dissection combined with endoscopic ultrasonography-assisted location of an extraluminally growing stromal tumor Open
A 70-year-old gentleman was admitted with a suspected gastric submucosal tumor (SMT) detected by abdominal contrast computed tomography (CT) ([Fig. 1]) performed to investigate his complaints of dull pain in the abdomen. Preoperative endos…
View article: Advancing Gastroscope From Intraluminal to Extraluminal Dissection: Primary Experience of Laparo-gastroscopic Esophagectomy
Advancing Gastroscope From Intraluminal to Extraluminal Dissection: Primary Experience of Laparo-gastroscopic Esophagectomy Open
Transhiatal esophagectomy facilitates esophageal resection without the need for thoracotomy. However, this procedure carries the risks of blind and blunt dissection within the mediastinum. More recently, video-assisted or mediastinoscopic …
View article: Submucosal Tunneling Endoscopic Septum Division: A Novel Technique for Treating Zenker's Diverticulum
Submucosal Tunneling Endoscopic Septum Division: A Novel Technique for Treating Zenker's Diverticulum Open