Mengjuan Zhu
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View article: In vivo CAR-T cell engineering: concept, research progress, potential challenges and enhancement strategies
In vivo CAR-T cell engineering: concept, research progress, potential challenges and enhancement strategies Open
After decades of development and accumulation, chimeric antigen receptor (CAR)-T therapy has become a revolutionary immunotherapy method, which has triggered changes in treatment methods and concepts in the fields of cancer, autoimmune dis…
View article: Progression of glioma through PU.1-mediated suppression of macrophage phagocytosis via targeting Siglec-10
Progression of glioma through PU.1-mediated suppression of macrophage phagocytosis via targeting Siglec-10 Open
Macrophage-mediated tumor cell phagocytosis and neoantigen presentation are essential for anti-tumor immunity. This study aimed to investigate the clinical relevance and molecular mechanism of the macrophage-associated transcription factor…
View article: Exploring CAR-macrophages in non-tumor diseases: Therapeutic potential beyond cancer
Exploring CAR-macrophages in non-tumor diseases: Therapeutic potential beyond cancer Open
This review provides a comprehensive understanding of CAR-M for the treatment of non-tumor diseases, analyzes the advantages and characteristics of CAR-M therapy, and highlights the important impact of CAR intracellular domain design on th…
View article: Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape
Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape Open
Immune cell therapy based on chimeric antigen receptor (CAR) technology platform has been greatly developed. The types of CAR immune cell therapy have expanded from T cells to innate immune cells such as NK cells and macrophages, and the d…
View article: Ferulic acid pretreatment alleviates heat stress in blueberry seedlings by inducing antioxidant enzymes, proline, and soluble sugars
Ferulic acid pretreatment alleviates heat stress in blueberry seedlings by inducing antioxidant enzymes, proline, and soluble sugars Open
Heat causes stress in blueberry; therefore, the present study aimed to investigate whether exogenous ferulic acid (FA) might protect plants against heat stress and to analyze possible mechanisms underlying such protection. Blueberry (Vacci…
View article: Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata
Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata Open
The preliminary structure, in vitro antioxidant and in vivo hepatoprotective activities of water-soluble polysaccharides (ORWP) and alkali-soluble polysaccharides (ORAP), prepared from the mushroom Oudemansiella radicata, were investigated…
View article: Purification and Characterization of a White Laccase with Pronounced Dye Decolorizing Ability and HIV-1 Reverse Transcriptase Inhibitory Activity from Lepista nuda
Purification and Characterization of a White Laccase with Pronounced Dye Decolorizing Ability and HIV-1 Reverse Transcriptase Inhibitory Activity from Lepista nuda Open
A strain LN07 with high laccase yield was identified as basidiomycete fungus Lepista nuda from which a white laccase without type I copper was purified and characterized. The laccase was a monomeric protein with a molecular mass of 56 kDa.…
View article: A novel laccase from fresh fruiting bodies of the wild medicinal mushroom Tricholoma matsutake
A novel laccase from fresh fruiting bodies of the wild medicinal mushroom Tricholoma matsutake Open
The knowledge about biological activities of constituents from medicinal mushrooms belonging to the genus Tricholoma is limited. A 59-kDa laccase has now been purified from fresh fruiting bodies of the mushroom Tricholoma matsutake. The pu…