This review provides a comprehensive understanding of CAR-M for the treatment of non-tumor diseases, analyzes the advantages and characteristics of CAR-M therapy, and highlights the important impact of CAR intracellular domain design on therapeutic efficacy. In addition, the challenges and clinical translation prospects of developing CAR-M as a new cell therapy are discussed.

Macrophage-mediated tumor cell phagocytosis and neoantigen presentation are essential for anti-tumor immunity. This study aimed to investigate the clinical relevance and molecular mechanism of the macrophage-associated transcription factor PU.1 in glioma. Tumor samples from patients with glioma were analyzed along with in vivo and in vitro models using PU.1 knockdown, RNA-seq, quantitative real-time reverse transcription polymerase chain reaction, western blotting, immunofluorescence, flow cytometry, and luciferas…

Abstract After decades of development and accumulation, chimeric antigen receptor (CAR)-T therapy has become a revolutionary immunotherapy method, which has triggered changes in treatment methods and concepts in the fields of cancer, autoimmune disorders, infection, fibrosis and other diseases. With the continuous expansion of indications and potential application fields, adoptive CAR-T therapy products are difficult to meet the expanding market demand and provide equal access to treatment due to their technical c…

Immune cell therapy based on chimeric antigen receptor (CAR) technology platform has been greatly developed. The types of CAR immune cell therapy have expanded from T cells to innate immune cells such as NK cells and macrophages, and the diseases treated have expanded from hematological malignancies to non-tumor fields such as infectious diseases and autoimmune diseases. Among them, CAR-T and CAR-NK therapy have observed examples of rapid remission in approved clinical trials, but the efficacy is unstable and plag…

Heat causes stress in blueberry; therefore, the present study aimed to investigate whether exogenous ferulic acid (FA) might protect plants against heat stress and to analyze possible mechanisms underlying such protection. Blueberry (Vaccinium corymbosum) seedlings were pretreated with 0.6 mM FA for 1 d and then kept at normal (25/20 °C) or elevated (39/30 °C) temperatures for 3 d. One day of FA pretreatment increased transcriptions of genes encoding iron superoxide dismutase, cytoplasmic copper/zinc superoxide di…