Mingquan Guo
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View article: 8-Nitrotryptanthrin inhibits colorectal cancer progression via TGF-β/SMAD and PI3K/AKT/mTOR pathways
8-Nitrotryptanthrin inhibits colorectal cancer progression via TGF-β/SMAD and PI3K/AKT/mTOR pathways Open
Objective To investigate the anticancer effects and underlying mechanisms of 8-nitrotryptanthrin (8-Nitrotryp) against colorectal cancer (CRC). Methods The effects of 8-Nitrotryp on proliferation, colony formation, and migration were evalu…
View article: Bioactive compounds with anti-obesity potential from Cassia obtusifolia L. explored by lipase-immobilized magnetic metal-organic frameworks and UPLC-Q-TOF-MS/MS
Bioactive compounds with anti-obesity potential from Cassia obtusifolia L. explored by lipase-immobilized magnetic metal-organic frameworks and UPLC-Q-TOF-MS/MS Open
The seeds of Cassia obtusifolia L. (Cassia seed) have long been utilized as an edible traditional Chinese medicinal herb and tea with various health benefits, including improving obesity and protecting eyesight. In this work, we developed …
View article: Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications
Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications Open
Optical biosensors are gaining popularity owing to their portability, miniaturization, no requirement for additional attachments and rapid responsiveness. These features render them suitable for various applications including at-home diagn…
View article: Natural products in neurodegenerative diseases: recent advances and future outlook
Natural products in neurodegenerative diseases: recent advances and future outlook Open
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s are on the rise and pose significant challenges due to the lack of effective treatments. This review critically examines the neuroprotective effects of various n…
View article: Rapid Screening of Lipase Inhibitors from Chrysanthemum Indicum L. Combing Lipase-Immobilized Polypropylene Hollow Fibers With Uplc-Qtof-Ms/Ms and Molecular Networking
Rapid Screening of Lipase Inhibitors from Chrysanthemum Indicum L. Combing Lipase-Immobilized Polypropylene Hollow Fibers With Uplc-Qtof-Ms/Ms and Molecular Networking Open
View article: Distinct Lateral Hypothalamus GABAergic Projections Regulate Sensory and Affective Dimensions of Pain
Distinct Lateral Hypothalamus GABAergic Projections Regulate Sensory and Affective Dimensions of Pain Open
View article: General concept of a deep hot water drilling system and drilling strategy to access Subglacial Lake Qilin, East Antarctica
General concept of a deep hot water drilling system and drilling strategy to access Subglacial Lake Qilin, East Antarctica Open
Deep Antarctic subglacial lakes represent physically unexplored aquatic environments, the investigation of which may provide unique information about microbial evolution, past climate of the Earth, and formation of the Antarctic ice sheet.…
View article: Hypoglycemic and hypolipidemic bioactive compounds from edible traditional Chinese medicines and their action of mechanisms explored by multitarget affinity ultrafiltration with liquid chromatography–mass spectrometry
Hypoglycemic and hypolipidemic bioactive compounds from edible traditional Chinese medicines and their action of mechanisms explored by multitarget affinity ultrafiltration with liquid chromatography–mass spectrometry Open
Edible traditional Chinese medicines (TCMs) have a long‐standing history in tackling obesity, diabetes, and metabolic diseases, which, in turn, significantly promotes the exploration of functional food products derived from edible TCMs wit…
View article: Potential hypoglycemic and hypolipidemic bioactive constituents in <i>Cyclocarya paliurus</i> leaves explored by affinity ultrafiltration with α‐glucosidase and pancreatic lipase
Potential hypoglycemic and hypolipidemic bioactive constituents in <i>Cyclocarya paliurus</i> leaves explored by affinity ultrafiltration with α‐glucosidase and pancreatic lipase Open
Cyclocarya paliurus has been widely applied for therapeutic feeding as a traditional Chinese medicine homologous food with high nutritional and medical value. Nevertheless, the specific bioactive compounds liable for hypoglycemic and hypol…
View article: Potential antioxidative and anti-hyperuricemic components in Rodgersia podophylla A. Gray revealed by bio-affinity ultrafiltration with SOD and XOD
Potential antioxidative and anti-hyperuricemic components in Rodgersia podophylla A. Gray revealed by bio-affinity ultrafiltration with SOD and XOD Open
Rodgersia podophylla A. Gray ( R. podophylla ) is a traditional Chinese medicine with various pharmacological effects. However, its antioxidant and anti-hyperuricemia components and mechanisms of action have not been explored yet. In this …
View article: Genomic epidemiology of hypervirulent carbapenem-resistant Klebsiella pneumoniae at Jinshan local hospital, Shanghai, during 2014–2018
Genomic epidemiology of hypervirulent carbapenem-resistant Klebsiella pneumoniae at Jinshan local hospital, Shanghai, during 2014–2018 Open
The Hv-CRKP ST11-KL64 has rapidly replaced ST11-KL47 and emerged as the predominant epidemic subtype in various hospital wards, highlighting the importance of conducting comprehensive early surveillance for Hv-CRKP, especially in respirato…
View article: Aporphine alkaloids identified from Xylopia aethiopica and their potential hypoglycemic and hypolipidemic activities
Aporphine alkaloids identified from Xylopia aethiopica and their potential hypoglycemic and hypolipidemic activities Open
Xylopia aethiopica has been widely utilized as food condiments in West African countries, as well as traditional medicine for diabetes, but the responsible components remain unknown. In this work, the probable active components in the cont…
View article: <i>Gymnema sylvestre</i> extract ameliorated streptozotocin‐induced hyperglycemia in T2DM rats via gut microbiota
<i>Gymnema sylvestre</i> extract ameliorated streptozotocin‐induced hyperglycemia in T2DM rats via gut microbiota Open
Gymnema sylvestre (GS) has been traditionally used to treat diabetes mellitus (DM) and consumed as both food and medicine. The present work aimed to reveal the arresting hypoglycemic properties of GS leaves on type 2 DM (T2DM) rats meditat…
View article: Explored potential hypoglycemic, hypolipidemic, and anti‐hyperuricemic components from <i>Rheum tanguticum</i> combing affinity ultrafiltration with four enzyme targets
Explored potential hypoglycemic, hypolipidemic, and anti‐hyperuricemic components from <i>Rheum tanguticum</i> combing affinity ultrafiltration with four enzyme targets Open
Due to its variety of biological activities, rhubarb has been widely applied worldwide with a long history. However, the potential bioactive compounds in Rheum tanguticum responsible for hypoglycemic, hypolipidemic, and anti‐hyperuricemic …
View article: Potential multifunctional components explored in Chinese herbal medicine against hepatitis B combining multi-target affinity ultrafiltration HPLC/MS
Potential multifunctional components explored in Chinese herbal medicine against hepatitis B combining multi-target affinity ultrafiltration HPLC/MS Open
Background: Dysosma versipellis (D. versipellis) and Phyllanthus urinaria (P. urinaria) are two typical Chinese herbs with diverse chemical composition and affluent pharmacological activities. Yet, the specific bioactive components with an…
View article: Editorial: Recent advances in recognition of bioactive phytonutrients for specific targets in plant foods
Editorial: Recent advances in recognition of bioactive phytonutrients for specific targets in plant foods Open
EDITORIAL article Front. Nutr., 03 October 2022Sec. Food Chemistry Volume 9 - 2022 | https://doi.org/10.3389/fnut.2022.1018946
View article: What Approaches to Thwart Bacterial Efflux Pumps-Mediated Resistance?
What Approaches to Thwart Bacterial Efflux Pumps-Mediated Resistance? Open
An effective response that combines prevention and treatment is still the most anticipated solution to the increasing incidence of antimicrobial resistance (AMR). As the phenomenon continues to evolve, AMR is driving an escalation of hard-…
View article: Exploring potential antidiabetic and anti-inflammatory flavonoids from Euphorbia humifusa with an integrated strategy
Exploring potential antidiabetic and anti-inflammatory flavonoids from Euphorbia humifusa with an integrated strategy Open
E. humifusa Willd, a monoecious annual plant, native to Eastern Asia, has been traditionally attributed to the treatment and prevention of miscellaneous diseases, including diabetes mellitus and its associated complications. Earlier studie…
View article: Potential Antioxidative and Anti-Hyperuricemic Components Targeting Superoxide Dismutase and Xanthine Oxidase Explored from Polygonatum Sibiricum Red.
Potential Antioxidative and Anti-Hyperuricemic Components Targeting Superoxide Dismutase and Xanthine Oxidase Explored from Polygonatum Sibiricum Red. Open
Polygonatum sibiricum Red. (P. sibiricum) has been used as a traditional Chinese medicine with a wide range of pharmacology effects. However, the responsible bioactive compounds and their mechanisms of action concerning its antioxidative a…
View article: Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2
Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2 Open
We firstly showcased an experimental investigation on the correlations between bioactive phytochemicals of D. versipellis and their multiple drug targets reflecting its potential pharmacological activities, and further constructed a…
View article: Flavonoids from Selaginella doederleinii Hieron and Their Antioxidant and Antiproliferative Activities
Flavonoids from Selaginella doederleinii Hieron and Their Antioxidant and Antiproliferative Activities Open
Selaginella doederleinii Hieron. (S. doederleinii) is a traditional herb that is widely used in China to treat several ailments, but mainly cancer. Studies have been carried out to determine the phytochemicals ascribed to its pharmacologic…
View article: Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway
Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway Open
Janus kinases (JAKs) play a key role in subtly regulating proliferation, apoptosis, and differentiation of cancer cells, and their inhibitors are actively sought as new drug leads. By developing JAKs based affinity ultrafiltration method c…
View article: Molecular characterization of a Novel NAD+-dependent farnesol dehydrogenase SoFLDH gene involved in sesquiterpenoid synthases from Salvia officinalis
Molecular characterization of a Novel NAD+-dependent farnesol dehydrogenase SoFLDH gene involved in sesquiterpenoid synthases from Salvia officinalis Open
Salvia officinalis is one of the most important medicinal and aromatic plants in terms of nutritional and medicinal value because it contains a variety of vital active ingredients. Terpenoid compounds, particularly monoterpenes (C10) and s…
View article: Potential Anti-aging Components From Moringa oleifera Leaves Explored by Affinity Ultrafiltration With Multiple Drug Targets
Potential Anti-aging Components From Moringa oleifera Leaves Explored by Affinity Ultrafiltration With Multiple Drug Targets Open
Moringa oleifera ( M. oleifera ), widely used in tropical and subtropical regions, has been reported to possess good anti-aging benefits on skincare. However, the potential bioactive components responsible for its anti-aging effects, inclu…
View article: Potential Antioxidative Components in Azadirachta indica Revealed by Bio-Affinity Ultrafiltration with SOD and XOD
Potential Antioxidative Components in Azadirachta indica Revealed by Bio-Affinity Ultrafiltration with SOD and XOD Open
Azadirachta indica (A. indica) has been widely used due to its diverse pharmacological activities. However, there are currently few studies on its responsible antioxidant ingredients against superoxide dismutase (SOD) and xanthine oxidase …
View article: Potential multiple bioactive components from Sinopodophyllum hexandrum explored by affinity ultrafiltration with four drug targets
Potential multiple bioactive components from Sinopodophyllum hexandrum explored by affinity ultrafiltration with four drug targets Open
Background: : Sinopodophyllum hexandrum (S. hexandrum) is a typical Chinese herbal medicine with multiple components and pharmacological activities. However, the specific phytochemicals responsible for its anti-proliferative, anti-inflamma…
View article: Antiparasitic Activity of Azadirachta Indica and its Potential Active Compounds Revealed by Affinity Ultrafiltration with Acetylcholinesterase and Lactate Dehydrogenases
Antiparasitic Activity of Azadirachta Indica and its Potential Active Compounds Revealed by Affinity Ultrafiltration with Acetylcholinesterase and Lactate Dehydrogenases Open
View article: Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration
Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration Open
Podophyllum sinense ( P. sinense ) has been used as a traditional herbal medicine for ages due to its extensive pharmaceutical activities, including antiproliferative, anti-inflammatory, antiviral, insecticidal effects, etc. Nevertheless, …
View article: Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G0/G1 Cell Cycle Arrest and Antiproliferation in A549 Cells
Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G0/G1 Cell Cycle Arrest and Antiproliferation in A549 Cells Open
Warburgia ugandensis Sprague (WU) is a traditional medicinal plant used for the treatment of various diseases, including cancer, in Africa. This study aimed to evaluate the anti-non-small cell lung cancer (NSCLC) activities of WU against A…
View article: Potential Anti-Proliferative, Anti-Inflammatory and Anti-Viral Components from Sinopodophyllum Hexandrum Explored Using Bio-Affinity Ultrafiltration with Multiple Drug Targets
Potential Anti-Proliferative, Anti-Inflammatory and Anti-Viral Components from Sinopodophyllum Hexandrum Explored Using Bio-Affinity Ultrafiltration with Multiple Drug Targets Open
Background: Sinopodophyllum hexandrum ( S. hexandrum ) is a typical Chinese herbal medicine with numerous components and remarkable pharmacological activities. However, the specific phytochemicals responsible for its anti-proliferative, an…