Meng-Lan Wang
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View article: Therapeutic effect of hUC-MSCs from different transplantation routes on acute liver failure in rats
Therapeutic effect of hUC-MSCs from different transplantation routes on acute liver failure in rats Open
Objective Acute liver failure (ALF) is a rare yet serious clinical syndrome. Recent studies have indicated that stem cells can effectively treat this condition. However, the optimal route for stem cell transplantation in the treatment of A…
View article: Anti-fibrosis Effect of the Traditional Chinese Medicine Compound <i>Biejiaruangan</i> in Patients with Chronic Hepatitis B: A Retrospective Cohort Study
Anti-fibrosis Effect of the Traditional Chinese Medicine Compound <i>Biejiaruangan</i> in Patients with Chronic Hepatitis B: A Retrospective Cohort Study Open
Background Liver fibrosis is the intermediate stage of hepatic B virus (HBV) induced-chronic liver disease and a common pathway leading to liver cirrhosis and hepatocellular carcinoma (HCC). It is reversible and can be modified by treatme…
View article: A Corpus-Based Multifactorial Study of <i>Help</i>/<i>help to</i> Alternation in Learners’ Language: From the Perspective of Probabilistic Grammar
A Corpus-Based Multifactorial Study of <i>Help</i>/<i>help to</i> Alternation in Learners’ Language: From the Perspective of Probabilistic Grammar Open
This corpus-based multifactorial study delves deeper into the well-known alternation between bare and full infinitive complements, specifically regarding the help concordances. It extends the line of research to learners’ language producti…
View article: Synergistic anti-osteosarcoma cell effects of the methotrex-ate/PI3K/mTOR inhibitor nanoparticle codelivery system
Synergistic anti-osteosarcoma cell effects of the methotrex-ate/PI3K/mTOR inhibitor nanoparticle codelivery system Open
Advanced osteosarcoma (OS) has low responsiveness to treatment regimens. Methotrexate (MTX), the first-line chemotherapeutic agent for advanced OS, frequently suffers from severe side effects that lead to chemotherapy interruption. To impr…
View article: Mesenchymal Stem Cells Alleviate Acute Liver Failure through Regulating Hepatocyte Apoptosis and Macrophage Polarization
Mesenchymal Stem Cells Alleviate Acute Liver Failure through Regulating Hepatocyte Apoptosis and Macrophage Polarization Open
hUC-MSCs could alleviate ALF by regulating hepatocyte apoptosis and macrophage polarization, thus hUC-MSC-based cell therapy may be an alternative option for patients with ALF.
View article: Effectiveness and Safety of Tenofovir Alafenamide in Treatment-Naïve and Treatment-Experienced Patients with Chronic Hepatitis B: Results of a Real-World Study from China
Effectiveness and Safety of Tenofovir Alafenamide in Treatment-Naïve and Treatment-Experienced Patients with Chronic Hepatitis B: Results of a Real-World Study from China Open
Background: Tenofovir alafenamide (TAF) has been effective against naïve patients with chronic hepatitis B (CHB) in phase 3 clinical trials. However, its real-world data are still limited. Objectives: This study aimed to investigate the ef…
View article: Improved bone and renal safety in younger tenofovir disoproxil fumarate experienced chronic hepatitis B patients after switching to tenofovir alafenamide or entecavir
Improved bone and renal safety in younger tenofovir disoproxil fumarate experienced chronic hepatitis B patients after switching to tenofovir alafenamide or entecavir Open
Younger CHB patients on long-term TDF therapy are at high risk for bone and renal impairment, with the risk being reduced when switched to ETV or TAF.
View article: Effectiveness and safety of tenofovir amibufenamide and its comparison with tenofovir alafenamide in patients with chronic hepatitis B: results from a retrospective real-world study
Effectiveness and safety of tenofovir amibufenamide and its comparison with tenofovir alafenamide in patients with chronic hepatitis B: results from a retrospective real-world study Open
Background/aim: Tenofovir amibufenamide (TMF) has shown potent antiviral efficacy in randomized clinical studies. This study aimed to reveal the effectiveness and safety of tenofovir amibufenamide in the real world and compared tenofovir a…
View article: Tumor Microenvironment Responsive Nanomicelle with Folic Acid Modification Co-Delivery of Doxorubicin/Shikonin for Triple Negative Breast Cancer Treatment
Tumor Microenvironment Responsive Nanomicelle with Folic Acid Modification Co-Delivery of Doxorubicin/Shikonin for Triple Negative Breast Cancer Treatment Open
Triple negative breast cancer (TNBC), which has poor prognosis, easily develops drug resistance and metastasizes. In general, those TNBC characteristics are related to a high activation of the epithelial-mesenchymal transition (EMT) pathwa…
View article: Reported shocks, households' resilience and local food commercialization in Thailand
Reported shocks, households' resilience and local food commercialization in Thailand Open
Purpose The authors examine the factors affecting households' resilience capacities and the impacts of these capacities on household consumption and crop commercialization. Design/methodology/approach The authors use panel data of 1,648 ho…
View article: Upregulation of microRNA-125b-5p alleviates acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway
Upregulation of microRNA-125b-5p alleviates acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway Open
Background Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) are the two most common subtypes of liver failure. They are both life-threatening clinical problems with high short-term mortality. Although liver transplantati…
View article: Serum Pregenomic RNA Combined With Hepatitis B Core-Related Antigen Helps Predict the Risk of Virological Relapse After Discontinuation of Nucleos(t)ide Analogs in Patients With Chronic Hepatitis B
Serum Pregenomic RNA Combined With Hepatitis B Core-Related Antigen Helps Predict the Risk of Virological Relapse After Discontinuation of Nucleos(t)ide Analogs in Patients With Chronic Hepatitis B Open
Background and Aim Cessation of nucleos(t)ide analogs (NAs) therapy in patients with chronic hepatitis B (CHB) is uncommon. Although criteria for discontinuation appear in some guidelines, the indicators for assessing discontinuation of NA…
View article: Dynamics of Serum Pregenome RNA in Chronic Hepatitis B Patients Receiving 96-Month Nucleos(t)ide Analog Therapy
Dynamics of Serum Pregenome RNA in Chronic Hepatitis B Patients Receiving 96-Month Nucleos(t)ide Analog Therapy Open
Background Tissue covalently closed circular DNA (cccDNA) can reflect the activity of HBV replication. However, it is impractical to assess intrahepatic cccDNA in every outpatient. Serum pregenome RNA (pgRNA) is transcribed from intrahepat…
View article: A COVID-19 Patient Discharged According to Strict Discharge Standards: Viral Negativity in Both Nasopharynx and Feces
A COVID-19 Patient Discharged According to Strict Discharge Standards: Viral Negativity in Both Nasopharynx and Feces Open
Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) currently has spread all over the world. However, the dynamic characteristics of SARS-CoV-2 infections have not previously been described in detail. Here, we report a cured patie…
View article: Antiviral Therapy for Chronic HBV Infection With Persistently Normal Alanine Aminotransferase: Controversy and Consensus
Antiviral Therapy for Chronic HBV Infection With Persistently Normal Alanine Aminotransferase: Controversy and Consensus Open
ALT is one of the most sensitive biochemical indexes to reflect liver injury. It is generally believed that hepatitis B virus (HBV) infected patients with normal ALT levels are in either immune tolerance or low replication stage of the nat…
View article: Retrospective Analysis of the Clinical Efficacy of N-Acetylcysteine in the Treatment of Hepatitis B Virus Related Acute-on-Chronic Liver Failure
Retrospective Analysis of the Clinical Efficacy of N-Acetylcysteine in the Treatment of Hepatitis B Virus Related Acute-on-Chronic Liver Failure Open
Objective: HBV-related acute-on-chronic liver failure (HBV-ACLF) has a high mortality due to severe intrahepatic cholestasis and coagulation dysfunction, thus new treatment measures are urgently needed to improve the therapeutic effect. Th…
View article: Cell Heterogeneity, Rather Than Cell Solvents Affects the Behavior of Mesenchymal Stem Cells in Vitro and Vivo
Cell Heterogeneity, Rather Than Cell Solvents Affects the Behavior of Mesenchymal Stem Cells in Vitro and Vivo Open
Background: Mesenchymal stem cells (MSCs) have been approved to treat various diseases, but they have to be expanded in vitro to gain sufficient cell doses. During the process of expansion, some obstacles remain to be addressed before MSCs…
View article: Efficacy and safety of sofosbuvir-based pangenotypic direct-acting antiviral agents for chronic hepatitis C patients without genotype determination
Efficacy and safety of sofosbuvir-based pangenotypic direct-acting antiviral agents for chronic hepatitis C patients without genotype determination Open
Several new, pangenotypic direct-acting antiviral agents (DAAs) have been approved, may reduce the need for genotyping to guide therapy decisions for patients with chronic hepatitis C (CHC). This study aimed to investigate the efficacy and…
View article: IDDF2019-ABS-0335 Distribution and factors associated with serum HBV pregenomic RNA levels in chronic hepatitis B patients
IDDF2019-ABS-0335 Distribution and factors associated with serum HBV pregenomic RNA levels in chronic hepatitis B patients Open
Background The present study aimed to study the correlations of serum HBV pgRNA with serum HBsAg and HBcrAg, and further investigate the possible influencing factors of serum HBV pgRNA levels in a large cohort of Chinese CHB patients. Meth…
View article: IDDF2019-ABS-0333 Optimal drug administration manner would rescue partial virological response in chronic hepatitis B patients with entecavir or tenofovir treatment
IDDF2019-ABS-0333 Optimal drug administration manner would rescue partial virological response in chronic hepatitis B patients with entecavir or tenofovir treatment Open
Background Entecavir (ETV) and Tenofovir (TDF) are recommended as the first-line antiviral oral drugs in chronic hepatitis B (CHB) patients owing to their excellent antiviral efficacy and high barrier to resistance. But not all CHB patient…
View article: Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway
Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway Open
ApoA5 had a protective effect against LPS/D-GalN-induced fulminant liver failure in mice within a certain range by inhibiting TLR4-mediated NF-κB pathway.
View article: Satisfactory virological response and fibrosis improvement of sofosbuvir-based regimens for Chinese patients with hepatitis C virus genotype 3 infection: results of a real-world cohort study
Satisfactory virological response and fibrosis improvement of sofosbuvir-based regimens for Chinese patients with hepatitis C virus genotype 3 infection: results of a real-world cohort study Open
SOF-based regimens are highly effective in viral clearance and fibrosis remission for Chinese patients with HCV-GT3 infection. If available, SOF/VEL should be first considered.
View article: IDDF2018-ABS-0082 Quantification of circulating mir-125b-5p predicts survival in chronic hepatitis b patients with acute-on-chronic liver failure
IDDF2018-ABS-0082 Quantification of circulating mir-125b-5p predicts survival in chronic hepatitis b patients with acute-on-chronic liver failure Open
Background This study aimed to analyse serum levels of miR-125b-5p in CHB patients with varying degrees of liver damage and evaluate its value in predicting the short-term outcome of acute-on-chronic liver failure (ACLF). Methods CHB patie…
View article: IDDF2018-ABS-0081 Gradually decreasing of serum hbcrag in real-world chronic hepatitis B patients receiving long-term nucleot(s)ide analogues-based therapy
IDDF2018-ABS-0081 Gradually decreasing of serum hbcrag in real-world chronic hepatitis B patients receiving long-term nucleot(s)ide analogues-based therapy Open
Background This study aimed to investigate the detailed dynamics of qHBcrAg and influence factors of long-term qHBcrAg in a cohort of patients who had received over 8 years of continuous NAs therapy. Methods This was a retrospective study.…