Menglan Zhang
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View article: Coexistence of a novel SV2B-ALK, EML4-ALK double-fusion in a lung poorly differentiated adenocarcinoma patient and response to alectinib: a case report and literature review
Coexistence of a novel SV2B-ALK, EML4-ALK double-fusion in a lung poorly differentiated adenocarcinoma patient and response to alectinib: a case report and literature review Open
Background Anaplastic lymphoma kinase ( ALK ) rearrangement, the most common oncogenic rearrangement in lung adenocarcinoma, occurs in approximately 5% of non-small cell lung cancer (NSCLC) patients. EML4 gene is the most common partner of…
View article: Efficacy of azvudine plus dexamethasone in severe hospitalized patients with Omicron infection: a prospective multicenter study
Efficacy of azvudine plus dexamethasone in severe hospitalized patients with Omicron infection: a prospective multicenter study Open
Background Azvudine (AZV), the first Chinese oral anti-coronavirus disease 2019 (COVID-19) drug, has shown substantial clinical benefits to viral clearance and prognosis in patients with mild and common COVID-19. However, there is no evide…
View article: Relationship between serum iron, zinc, calcium, and HIF-1a—comparative analysis of 2 regions and 4 ethnic groups in China
Relationship between serum iron, zinc, calcium, and HIF-1a—comparative analysis of 2 regions and 4 ethnic groups in China Open
Background Altitude illness has serious effects on individuals who are not adequately acclimatized to high-altitude areas and may even lead to death. However, the individualized mechanisms of onset and preventive measures are not fully elu…
View article: Zinc homeostasis plays important roles in hypoxia tolerance, a study conducted clinically and in vitro
Zinc homeostasis plays important roles in hypoxia tolerance, a study conducted clinically and in vitro Open
Objective: To investigate the relationship between zinc homeostasis and hypoxia tolerance. Methods: Healthy individuals from highland (4500-5000 m, the QH group) and plain (0-200 m, the HH group), as well as high-altitude cerebral edema (H…
View article: Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma
Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma Open
View article: DNA-PKcs participated in hypoxic pulmonary hypertension
DNA-PKcs participated in hypoxic pulmonary hypertension Open
View article: Malignant Transformation in Vestibular Schwannoma: Clinical Study With Survival Analysis
Malignant Transformation in Vestibular Schwannoma: Clinical Study With Survival Analysis Open
Aim Vestibular schwannomas (VSs) are generally considered benign tumors, and malignant transformation of VSs (MTVSs) are rare findings. The clinical features, treatment strategy, outcomes and prognostic factors remain unclear. We endeavore…
View article: A high-quality genome assembly highlights rye genomic characteristics and agronomically important genes
A high-quality genome assembly highlights rye genomic characteristics and agronomically important genes Open
Rye is a valuable food and forage crop, an important genetic resource for wheat and triticale improvement and an indispensable material for efficient comparative genomic studies in grasses. Here, we sequenced the genome of Weining rye, an …
View article: Insight into the Regulatory Relationships between the Insulin-Like Androgenic Gland Hormone Gene and the Insulin-Like Androgenic Gland Hormone-binding Protein Gene in Giant Freshwater Prawns (Macrobrachium rosenbergii)
Insight into the Regulatory Relationships between the Insulin-Like Androgenic Gland Hormone Gene and the Insulin-Like Androgenic Gland Hormone-binding Protein Gene in Giant Freshwater Prawns (Macrobrachium rosenbergii) Open
Giant freshwater prawns (Macrobrachium rosenbergii) are commonly found throughout the world. The size of the male giant freshwater prawn is much larger than that of the female. Therefore, understanding the molecular mechanism that underlie…
View article: PITPNC1 fuels radioresistance of rectal cancer by inhibiting reactive oxygen species production
PITPNC1 fuels radioresistance of rectal cancer by inhibiting reactive oxygen species production Open
PITPNC1 fuels radioresistance of rectal cancer via the inhibition of ROS generation.
View article: Clinicopathologic characteristics of HER2-positive pure mucinous breast carcinoma: a systematic investigation into an unusual tumor.
Clinicopathologic characteristics of HER2-positive pure mucinous breast carcinoma: a systematic investigation into an unusual tumor. Open
Pure mucinous breast carcinoma (PMBC) accounts for approximately 2% of all breast carcinoma. Overexpression or amplification of human epidermal growth factor receptor 2 (HER2) is rarely observed in PMBC. We retrieved 119 PMBCs, which inclu…
View article: Clinicopathological and molecular characteristics of synchronous gastric adenocarcinoma and gastrointestinal stromal tumors
Clinicopathological and molecular characteristics of synchronous gastric adenocarcinoma and gastrointestinal stromal tumors Open
Synchronous gastric tumors that consist of both gastrointestinal stromal tumor (GIST) and adenocarcinoma are rare. We studied the clinicopathological and molecular characteristics of six cases containing both gastric adenocarcinoma and GIS…
View article: High glucose-induced Matrilin-2 expression in mouse mesangial cells was mediated by transforming growth factor beta 1 (TGF-β1)
High glucose-induced Matrilin-2 expression in mouse mesangial cells was mediated by transforming growth factor beta 1 (TGF-β1) Open