Menglei Ding
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View article: Network pharmacology-based study on the mechanism of Yiwei Decoction in chronic atrophic gastritis and experimental assessment
Network pharmacology-based study on the mechanism of Yiwei Decoction in chronic atrophic gastritis and experimental assessment Open
Objective: Yiwei Decoction (YWD) is an ancient TCM formula with historical use in treating chronic atrophic gastritis (CAG). However, its pharmacodynamic mechanisms remain poorly understood. This study aims to study the effect of YWD on CA…
View article: Alkaloids of Aconiti Lateralis Radix Praeparata inhibit growth of non-small cell lung cancer by regulating PI3K/Akt-mTOR signaling and glycolysis
Alkaloids of Aconiti Lateralis Radix Praeparata inhibit growth of non-small cell lung cancer by regulating PI3K/Akt-mTOR signaling and glycolysis Open
Aconiti Lateralis Radix Praeparata (Fuzi in Chinese) is widely used in the clinical treatment of tumors. This study aims to explore the active fractions and underlying mechanisms of Fuzi in the treatment of non-small cell lung cancer (NSCL…
View article: The prevalence of IgG anti-ACE2 antibody in patients with COVID-19 and its suggestive role in the progression of COVID-19
The prevalence of IgG anti-ACE2 antibody in patients with COVID-19 and its suggestive role in the progression of COVID-19 Open
Angiotensin converting enzyme-2 (ACE2), a key component in renin-angiotensin system (RAS) has been identified as the functional receptor for mediating the entry into the cell of SARS-CoV-2. The correlation between anti-ACE2 antibodies and …
View article: Alkaloids of Aconiti Lateralis Radix Praeparata treated non-small cell lung cancer by regulating glycolysis via the PI3K/AKT-mTOR signaling pathway
Alkaloids of Aconiti Lateralis Radix Praeparata treated non-small cell lung cancer by regulating glycolysis via the PI3K/AKT-mTOR signaling pathway Open
Background: Aconiti Lateralis Radix Praeparata (Fuzi) is widely used in the clinical treatment of tumors. Numerous researches demonstrated that Fuzi had significant anti-tumor effects, while the active components of Fuzi and corresponding …
View article: Preparation of mesoporous silica nanocarriers targeting glucose-6-phosphate isomerase inhibition and application in the treatment of rheumatoid arthritis
Preparation of mesoporous silica nanocarriers targeting glucose-6-phosphate isomerase inhibition and application in the treatment of rheumatoid arthritis Open
Glucose 6-phosphate isomerase (G6PI) is an indicator to assist in diagnosis of rheumatoid arthritis (RA) and monitor the disease. It also plays a key role in proliferating RA synovial tissues, pannus formation, and invasion and destruction…
View article: Hypoxia Inhibits Osteogenesis and Promotes Adipogenesis of Fibroblast-like Synoviocytes via Upregulation of Leptin in Patients with Rheumatoid Arthritis
Hypoxia Inhibits Osteogenesis and Promotes Adipogenesis of Fibroblast-like Synoviocytes via Upregulation of Leptin in Patients with Rheumatoid Arthritis Open
Hypoxia is associated with the pathogenesis of rheumatoid arthritis (RA). RA fibroblast-like synoviocytes (FLSs) are able to differentiate into osteoblasts and adipocytes. In this study, we aimed to investigate the role of hypoxia in the o…
View article: Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis
Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis Open
View article: Identification of key genes involved in calcific aortic valve disease based on integrated bioinformatics analysis
Identification of key genes involved in calcific aortic valve disease based on integrated bioinformatics analysis Open
The calcific aortic valve disease (CAVD) develops as an aortic valve sclerosis and progresses to an advanced form of stenosis. In many biological fields, bioinformatics becomes a fundamental component. The key mechanisms involved in CAVD a…
View article: Cationic Amino Acid Transporter-1 (CAT-1) Promotes Fibroblast-Like Synoviocytes Proliferation and Cytokine Secretion by Taking Up L-Arginine in Rheumatoid Arthritis
Cationic Amino Acid Transporter-1 (CAT-1) Promotes Fibroblast-Like Synoviocytes Proliferation and Cytokine Secretion by Taking Up L-Arginine in Rheumatoid Arthritis Open
Background: Abnormal proliferation of fibroblast-like synoviocytes (FLSs) in the synovial lining layer is the primary cause of synovial hyperplasia and joint destruction in rheumatoid arthritis (RA). Currently, the relationship between met…
View article: Author Correction: mTORC1 Maintains the Tumorigenicity of SSEA-4 + High-Grade Osteosarcoma
Author Correction: mTORC1 Maintains the Tumorigenicity of SSEA-4 + High-Grade Osteosarcoma Open
View article: The Regulation of Macrophage Polarization by Hypoxia-PADI4 Coordination in Rheumatoid Arthritis
The Regulation of Macrophage Polarization by Hypoxia-PADI4 Coordination in Rheumatoid Arthritis Open
Background : Hypoxia, a common feature of rheumatoid arthritis (RA), induces the overexpression of peptidyl arginine deiminase 4 (PADI4) in fibroblast-like synoviocytes (FLSs) and macrophages. However, the roles of PADI4 and its inducer hy…
View article: Research on and Application of the Control of Manhole Cover in the Launching Silo Based on Machine Vision Technology
Research on and Application of the Control of Manhole Cover in the Launching Silo Based on Machine Vision Technology Open
The manhole cover is an important for the launching device as a whole because its uncovering is vital to the whole switching process. The contact switch is now mainly used to judge whether the manhole cover is in place; however, in this wa…
View article: mTORC1 Maintains the Tumorigenicity of SSEA-4+ High-Grade Osteosarcoma
mTORC1 Maintains the Tumorigenicity of SSEA-4+ High-Grade Osteosarcoma Open