Menglu Jin
YOU?
Author Swipe
View article: Efficient Recovery of Complete Gut Viral Genomes by Combined Short‐ and Long‐Read Sequencing
Efficient Recovery of Complete Gut Viral Genomes by Combined Short‐ and Long‐Read Sequencing Open
Current metagenome assembled human gut phage catalogs contained mostly fragmented genomes. Here, comprehensive gut virome detection procedure is developed involving virus‐like particle (VLP) enrichment from ≈500 g feces and combined sequen…
View article: Long‐Read Sequencing Reveals Extensive DNA Methylations in Human Gut Phagenome Contributed by Prevalently Phage‐Encoded Methyltransferases
Long‐Read Sequencing Reveals Extensive DNA Methylations in Human Gut Phagenome Contributed by Prevalently Phage‐Encoded Methyltransferases Open
DNA methylation plays a crucial role in the survival of bacteriophages (phages), yet the understanding of their genome methylation remains limited. In this study, DNA methylation patterns are analyzed in 8848 metagenome‐assembled high‐qual…
View article: Long-read sequencing reveals extensive DNA methylations in human gut phagenome contributed by prevalently phage-encoded methyltransferases
Long-read sequencing reveals extensive DNA methylations in human gut phagenome contributed by prevalently phage-encoded methyltransferases Open
DNA methylation is essential for the survival of bacteriophages (phages), yet, we know little about the methylation of their genomes. Here, we analyze the DNA methylation patterns of 8,848 metagenome-assembled high-quality phages across 10…
View article: Enrichment Culture but Not Metagenomic Sequencing Identified a Highly Prevalent Phage Infecting <i>Lactiplantibacillus plantarum</i> in Human Feces
Enrichment Culture but Not Metagenomic Sequencing Identified a Highly Prevalent Phage Infecting <i>Lactiplantibacillus plantarum</i> in Human Feces Open
As Lactiplantibacillus plantarum (previously known as Lactobacillus plantarum ) is increasingly used as a probiotic to treat human gut-related diseases, its bacteriophages may pose a certain threat to their further application and should b…
View article: An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli
An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli Open
Pathogenic strains of Escherichia coli are responsible for 0.8 million deaths per year and together ranked the first among all pathogenic species. Here, we obtained, for the first time, an engineered phage, Eλ, that could specifically and …
View article: Efficient recovery of complete gut phage genomes by combined short- and long-sequencing
Efficient recovery of complete gut phage genomes by combined short- and long-sequencing Open
Current metagenome-assembled human phage catalogs contained mostly fragmented genomes. Here, we developed a vigorous phage detection method involving phage enrichment and long-read sequencing and applied to 135 fecal samples. With ~10 time…
View article: Genetic and Chemical Engineering of Phages for Controlling Multidrug-Resistant Bacteria
Genetic and Chemical Engineering of Phages for Controlling Multidrug-Resistant Bacteria Open
Along with the excessive use of antibiotics, the emergence and spread of multidrug-resistant bacteria has become a public health problem and a great challenge vis-à-vis the control and treatment of bacterial infections. As the natural pred…
View article: Dynamic metabolomic analysis of intestinal ischemia–reperfusion injury in rats
Dynamic metabolomic analysis of intestinal ischemia–reperfusion injury in rats Open
Intestinal ischemia–reperfusion injury (IIR) is a life‐threatening abdominal emergency. Compared to traditional steady‐state works, we profiled the blood of rats over 72 hr (15 time points) and examined dynamic changes in molecular pathway…