Mengping Liu
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View article: Association between the atherogenic index of plasma, body mass index, and cardiovascular diseases in Chinese middle and old-aged adults: a mediation analysis
Association between the atherogenic index of plasma, body mass index, and cardiovascular diseases in Chinese middle and old-aged adults: a mediation analysis Open
Background Evidence has emerged that suggests the atherogenic index of plasma (AIP), as determined by blood lipid levels, is a valuable predictor of the onset of cardiovascular diseases. The correlation between AIP and cardiovascular disea…
View article: Impacts of fracturing fluid viscosity and injection rate variations on the fracture network propagation in deep coalbed reservoirs
Impacts of fracturing fluid viscosity and injection rate variations on the fracture network propagation in deep coalbed reservoirs Open
Adjusting the fracturing fluid viscosity and injection rate effectively enhances complex fracture network generation and increases stimulated reservoir volume (SRV). However, the underlying mechanical mechanisms still remain critically und…
View article: Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates
Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates Open
Safely achieving therapeutic expression levels with adeno-associated virus (AAV) gene therapy is a significant challenge for treating the large muscle mass in humans. Non-human primates (NHPs) provide a more accurate assessment of the feas…
View article: The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration
The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration Open
Recombinant human bone morphogenetic protein 2 (rhBMP-2) is an FDA-approved growth factor for bone regeneration and repair in medical practice. The therapeutic effects of rhBMP-2 may be enhanced through specific binding to extracellular ma…
View article: Electrospinning Fibers Modified with Near Infrared Light‐Excited Copper Nanoparticles for Antibacterial and Bone Regeneration
Electrospinning Fibers Modified with Near Infrared Light‐Excited Copper Nanoparticles for Antibacterial and Bone Regeneration Open
Bone infection is an inflammatory bone disease caused by infectious microorganisms, which can lead to progressive bone destruction and loss. It is still an urgent and unmet clinical need to develop a rapid and effective sterilized method t…
View article: Modulating oxygen vacancy concentration on Bi<sub>4</sub>V<sub>2</sub>O<sub>11</sub> nanorods for synergistic photo-driven plastic waste oxidation and CO<sub>2</sub> reduction
Modulating oxygen vacancy concentration on Bi<sub>4</sub>V<sub>2</sub>O<sub>11</sub> nanorods for synergistic photo-driven plastic waste oxidation and CO<sub>2</sub> reduction Open
Synergistic photo-driven plastic waste oxidation and CO 2 reduction on Bi 4 V 2 O 11 nanorods with abundant oxygen vacancies.
View article: The lifestyle factors of physical activity and diet balance associated with HPV infection in China: The cross-sectional study
The lifestyle factors of physical activity and diet balance associated with HPV infection in China: The cross-sectional study Open
Background Human wellbeing has been linked with lifestyle factors such as physical activity, diet balance, sleep quality, depression, and anxiety. However, few studies illustrate the relationship between such lifestyle factors and HPV infe…
View article: The Influence of Vaginal Microbiome and Clinical Factors on HPV Clearance: A Prospective Study
The Influence of Vaginal Microbiome and Clinical Factors on HPV Clearance: A Prospective Study Open
Background Although the microbiome and lifestyle factors are associated with HPV clearance, few studies have systematically explored the relevant factors. This formal follow-up prospective study aims to predict HPV clearance based on vagin…
View article: A cost-effectiveness of Fecal DNA methylation test for colorectal cancer screening in Saudi Arabia
A cost-effectiveness of Fecal DNA methylation test for colorectal cancer screening in Saudi Arabia Open
Background In the Saudi Arabia, we estimated the cost-effectiveness between fecal DNA methylation test (FDMT) and fecal immunochemical testing (FIT) to detect colorectal cancer (CRC) and precancerous lesions in the national screening progr…
View article: Vaginal microbiota and personal risk factors associated with HPV status conversion—A new approach to reduce the risk of cervical cancer?
Vaginal microbiota and personal risk factors associated with HPV status conversion—A new approach to reduce the risk of cervical cancer? Open
Vaginal microbiota (VMB) is associated with changes in Human papilloma virus (HPV) status, which consequently influences the risk of cervical cancer. This association was often confounded by personal risk factors. This pilot research aimed…
View article: The Lifestyle Factors of Physical Activity and Diet Balance associated with HPV Infection
The Lifestyle Factors of Physical Activity and Diet Balance associated with HPV Infection Open
Background Human wellbeing has been linked with lifestyle factors such as physical activity, diet balance, sleep quality, depression, and anxiety. However, few studies illustrate the relationship between such lifestyle factors and HPV infe…
View article: Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging Open
A wide variety of nanomaterials have emerged in recent years with advantageous properties for a plethora of therapeutic and diagnostic applications. Such applications include drug delivery, imaging, anti-cancer therapy and radiotherapy. Th…
View article: MiR-210-3p attenuates lipid accumulation and inflammation in atherosclerosis by repressing IGF2
MiR-210-3p attenuates lipid accumulation and inflammation in atherosclerosis by repressing IGF2 Open
Previous studies have shown that miR-210-3p is involved in the development and progression of atherosclerosis, but its specific mechanisms are still unclear. This study aims to reveal the mechanism of miR-210-3p and its target genes in mac…
View article: Structure–Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors
Structure–Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors Open
In solving the P-gp and BCRP transporter-mediated efflux issue in a series of benzofuran-derived pan-genotypic palm site inhibitors of the hepatitis C virus NS5B replicase, it was found that close attention to physicochemical properties wa…
View article: Bioconcentration and Metabolism of Emodin in Zebrafish Eleutheroembryos
Bioconcentration and Metabolism of Emodin in Zebrafish Eleutheroembryos Open
Emodin is a major active anthraquinone of various herbal laxatives, which can exert many pharmacological effects. However, chronic use of anthranoid laxatives, even at low dosages, may cause melanosis coli (MC). It has been suggested that …
View article: Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor Open
Iterative structure-activity analyses in a class of highly functionalized furo[2,3-b]pyridines led to the identification of the second generation pan-genotypic hepatitis C virus NS5B polymerase primer grip inhibitor BMT-052 (14), a potenti…
View article: Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies Open
The hepatitis C virus (HCV) NS5B replicase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection. Inspired by the overlay of bound structures of three structurally distinct NS5B p…
View article: CCDC 1541557: Experimental Crystal Structure Determination
CCDC 1541557: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …