Explanipedia

Development and Validation of an Explainable Machine Learning Model for Warning of Hepatitis E Virus‐Related Acute Liver Failure Open

Rui Dong, Zhenghan Luo, Hong Xue, Jianguo Shao, Lin Chen , et al. · 2025

Background and Aims Early identification of patients with acute hepatitis E (AHE) who are at high risk of progressing to hepatitis E virus‐related acute liver failure (HEV‐ALF) is crucial for enabling timely monitoring and intervention. Th…

Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development Open

Guo‐Jen Huang, Xin Dong, Xiaoxiao Shao, Mengping Wu, Shan Gao , et al. · 2025

Background Migraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population. Methods The research analyzed specific …

Compensation preferences of home-based disabled beneficiaries in the long-term care insurance system in Guangzhou, China Open

Yi Qian, Yusupujiang Tuersun, Duqiao Li, Lan Luo, Yanqi Kou , et al. · 2025

This study explores the preferences and willingness-to-pay of home-based disabled elderly individuals for long-term care insurance (LTCI) compensation mechanisms in Guangzhou, China, using a discrete choice experiment. The research aims to…

Spirituality and Attitudes Toward Death Among Older Adults in Rural and Urban China: A Cross-Sectional Study Open

Xiucheng Jiang, Weinan Lu, Hui Luo, Jianhua Yang, Min Chen , et al. · 2023

Forkhead Box Protein A1 is a Prognostic Predictor and Promotes Tumor Growth of Gastric Cancer [Retraction] Open

Hong‐Yu Ren, Pei Zhang, Yong Tang, Mengping Wu, Weikang Zhang · 2022

[This retracts the article DOI: 10.2147/OTT.S91035.].

The utility of sputum supernatant as an alternative liquid biopsy specimen for next-generation sequencing-based somatic variation profiling Open

Ling Qin, Ting Guo, Huaping Yang, Pengbo Deng, Qihua Gu , et al. · 2022

Our study demonstrated that supernatant fraction from induced sputum is a better sampling source than its sediment and performs comparably to plasma samples. Induced sputum from NSCLC patients could serve as an alternative media for next-g…

Aberrant methylation of aging-related genes in asthma Open

Yu Yang, Lin Yuan, Ming Yang, Xizi Du, Ling Qin , et al. · 2022

Background: Asthma is a complex pulmonary inflammatory disease which is common among older adults.Aging-related alterations have also been found in structural cells and immune cells of asthma patients. Of note, DNA methylation have been pr…

ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells Open

Xizi Du, Yang Yu, Ming Yang, Yuan Lin, Leyuan Wang , et al. · 2021

Respiratory syncytial virus (RSV) infection is the main cause of bronchiolitis in children. Excessive mucus secretion is one of the primary symbols in RSV related lower respiratory tract infections (RSV-related LRTI), which is closely asso…

Involvement of epithelia-derived exosomes in chronic respiratory diseases Open

Yu Yang, Lin Yuan, Xizi Du, Kai Zhou, Ling Qin , et al. · 2021

Exosomes are tiny membrane lipid bilayer vesicles (φ40-100 nm) formed by the fusion of multivesicular bodies with plasma membrane, which are released extracellular by exocytosis. As natural nanocarriers, exosomes contain a variety of signa…

Innate lymphoid cells are double‐edged swords under the mucosal barrier Open

Zhen Duan, Mandie Liu, Yuan Lin, Xizi Du, Mengping Wu , et al. · 2021

As the direct contacting site for pathogens and allergens, the mucosal barrier plays a vital role in the lungs and intestines. Innate lymphoid cells (ILCs) are particularly resident in the mucosal barrier and participate in several pathoph…

Aberrant Methylation of Aging-Related Genes in Asthma Open

Yu Yang, Lin Yuan, Ming Yang, Xizi Du, Ling Qin , et al. · 2021

Background: Asthma is a complex pulmonary inflammatory disease which is common among older adults. Aging-related alterations have also been found in structural cells and immune cells of asthma patients. Nonetheless, the underlying mechanis…

Correction to: The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma Open

Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang , et al. · 2021

An amendment to this paper has been published and can be accessed via the original article.

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma Open

Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang , et al. · 2020

Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population Open

Ru Zhang, Zuqiang Fu, Haozhi Fan, Ting Tian, Mengping Wu , et al. · 2020

Genetic variation of related genes in Vitamin D (VD) metabolic pathway played an important role in antiviral immune response and chronic hepatitis C virus (HCV) infection. Retinoid X receptor (RXR) is one of the key genes in the metabolism…

The utility of sputum supernatant as an alternative liquid biopsy specimen for next-generation sequencing-based genomic profiling Open

Ling Qin, Ting Guo, Huaping Yang, Pengbo Deng, Qihua Gu , et al. · 2020

Background Comprehensive mutation profiling has become a standard clinical practice in the management of advanced lung cancer. In addition to tissue and plasma, other body fluids are also being actively explored as alternative sources of t…

Variable expressed methylation sites of aging-related genes in asthma Open

Yu Yang, Lin Yuan, Ming Yang, Xizi Du, Ling Qin , et al. · 2020

Background: Asthma is a complex pulmonary inflammatory disease which is common in the elderly. Aging-related alterations have also been found in the structural cells and immune cells of asthma patients although the pathological mechanism o…

Association of the cyclooxygenase-2 1759A allele with migraine in Chinese Han individuals Open

Xinying Guan, Changhong Dong, Pinhuan Zhu, Cheng Chen, Teng Wang , et al. · 2020

Cyclooxygenase-2 (COX-2) is known to be involved in the pathogenesis of migraine, and some polymorphisms are known to affect the expression of COX-2. This retrospective case-control study aimed to explore the associations between the -765 …

Respiratory syncytial virus infection‐induced mucus secretion by down‐regulation of miR‐34b/c‐5p expression in airway epithelial cells Open

Xizi Du, Yang Yu, Gelei Xiao, Ming Yang, Yuan Lin , et al. · 2020

Severe RSV infection is the main cause of hospitalization to children under the age of five. The regulation of miRNAs on the severity of RSV infection is unclear. The aim of the study was to identify the critical differential expression mi…

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production Open

Yuan Lin, Xun Zhang, Ming Yang, Xizi Du, Leyuan Wang , et al. · 2020

Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4 (ITGB4) is a structural adhesion molecule that is down-regulated in the airway epithelium of asthma patients. Although a few studies hint tow…

Relationship between plasma total homocysteine and the severity of renal function in Chinese patients with type 2 diabetes mellitus aged ≥75 years Open

Ning Ma, Ning Xu, Dong Yin, Wei Wei Liu, Mengping Wu , et al. · 2020

We aimed to investigate the relationship between total homocysteine (tHcy) levels in the plasma and renal function severity in patients with type 2 diabetes mellitus (T2DM) aged ≥75 years. We included 221 patients with T2DM aged ≥60 years …

Time is of the Essence? Investigating How Culturally-Based Perceptions of Time Affect Hindsight Bias for Task Completion Open

Therese A. Louie, Mengping Wu · 2020

Hindsight bias, known as the “Monday Morning Quarterback” syndrome, occurs when individuals feel they would have been able to predict the outcome to past events. This research examined if hindsight effects for personally-relevant task comp…

Airway epithelial ITGB4 deficiency in early life mediates pulmonary spontaneous inflammation and enhanced allergic immune response Open

Sha Tang, Xizi Du, Yuan Lin, Gelei Xiao, Mengping Wu , et al. · 2020

Lung immune responses to respiratory pathogens and allergens are initiated in early life which will further influence the later onset of asthma. The airway epithelia form the first mechanical physical barrier to allergic stimuli and enviro…

Respiratory Syncytial Virus Infection Induced Mucus Secretion by Down Regulation of miR-34b/c-5p Expression in Airway Epithelial Cells Open

Xizi Du, Yuan Lin, Gelei Xiao, Ming Yang, Ling Qin , et al. · 2020

Variable DNA methylation of aging-related genes is associated with male COPD Open

Xizi Du, Lin Yuan, Mengping Wu, Meichao Men, Ruoxi He , et al. · 2019

Background Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease which has a close relationship with aging. Genome-wide analysis reveals that DNA methylation markers vary obviously with age. DNA methylation va…

CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population Open

Haozhi Fan, Ru Zhang, Ting Tian, Yuling Zhong, Mengping Wu , et al. · 2019

These findings indicate that SNPs in CYP24A1 gene may contribute to the risk of HCV infection and chronic HCV infection among a high-risk Chinese population.

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production Open

Yuan Lin, Xun Zhang, Ming Yang, Yizhou Zou, Yang Xiang , et al. · 2019

Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4 (ITGB4) is a structural adhesion molecule that is downregulated in the airway epithelium of asthma patients. Specific ITGB4 deficiency in AEC…

Ink-jet patterning of graphene by cap assisted barrier-guided CVD Open

Ding‐Rui Chen, Sheng‐Kuei Chiu, Mengping Wu, Chia‐Chen Hsu, Chu‐Chi Ting , et al. · 2019

High-resolution graphene patterning through ink-jet deposition of a barrier and subsequent CVD is achieved by a confinement-assisted growth process.

Genetic variations in vitamin D receptor were associated with the outcomes of hepatitis C virus infection among Chinese population Open

Mengping Wu, Jinwei Zhang, Peng Huang, Yaping Han, Yun Zhang , et al. · 2015

Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer Open

Weikang Zhang, Hong‐Yu Ren, Pei Zhang, Yong Tang, Mengping Wu · 2015

Previous studies have demonstrated the cancer-type specific role of forkhead box protein A1 (FOXA1) in human malignancies. However, the clinical significance of FOXA1 and its biological function in gastric cancer remain unknown. In this st…

Human Leukocyte Antigen Class II Alleles Are Associated with Hepatitis C Virus Natural Susceptibility in the Chinese Population Open

Ming Yue, Ke Xu, Mengping Wu, Yaping Han, Peng Huang , et al. · 2015

Human leukocyte antigen (HLA) class II molecule influences host antigen presentation and anti-viral immune response. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) within HLA class II gene were asso…

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