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View article: Analysis of reasons and risk factors for non-completion of radiotherapy courses in patients with tumors
Analysis of reasons and risk factors for non-completion of radiotherapy courses in patients with tumors Open
Purpose Non-completion of radiotherapy courses (NCRC) may happen in patients undergoing intensity-modulated radiotherapy (IMRT). Analyzing the reasons and risk factors for NCRC can lead to possible targeted measures to reduce the incidence…
View article: P0321 Early improvement of mental health is associated with long-term disease remission in Ulcerative Colitis
P0321 Early improvement of mental health is associated with long-term disease remission in Ulcerative Colitis Open
Background Emerging evidence underscore the critical role of mental health in managing ulcerative colitis. However, the potential impact of early mental health improvement on long-term therapeutic outcomes remains poorly understood. This s…
View article: Unfavorable Prognostic Impact of HER2 2+/FISH-Negativity in Older Patients with HER2-Negative and High-Risk Breast Cancer
Unfavorable Prognostic Impact of HER2 2+/FISH-Negativity in Older Patients with HER2-Negative and High-Risk Breast Cancer Open
In older patients with HER2-negative/high-risk breast cancer undergoing standard adjuvant chemotherapy, our findings suggest that HER2 2+/FISH-negativity has an independent negative impact on prognosis.
View article: [Effects of type 2 inflammation on bronchodilator responsiveness of large and small airways in chronic obstructive pulmonary disease].
[Effects of type 2 inflammation on bronchodilator responsiveness of large and small airways in chronic obstructive pulmonary disease]. Open
Type 2 inflammation markers have different effects on BDR in the large and small airways of COPD patients, and their clinical significance needs further investigation.
View article: P452 Serum Amyloid A for Predicting Surgery and Disease Exacerbation in Patients with Newly Diagnosed Crohn’s Disease
P452 Serum Amyloid A for Predicting Surgery and Disease Exacerbation in Patients with Newly Diagnosed Crohn’s Disease Open
Background Crohn's disease (CD) is characterized by relapsing-remitting course with highly heterogenous prognosis, ranging from quiescent disease to complicated course with stricturing, penetrating or need of abdominal surgery. Identifying…
View article: P776 A Prospective, Multicenter, Single-arm, Observational Study to Evaluate the Safety and Effectiveness of Vedolizumab in Real-world Clinical Practice in China: Interim Analysis of Safety results
P776 A Prospective, Multicenter, Single-arm, Observational Study to Evaluate the Safety and Effectiveness of Vedolizumab in Real-world Clinical Practice in China: Interim Analysis of Safety results Open
Background Crohn's disease (CD) and ulcerative colitis (UC) are categorized as inflammatory bowel disease [IBD] usually treated by corticosteroids, immunomodulators and biologics, etc. Vedolizumab, a gut-selective α4β7 integrin antibody, h…
View article: P187 Validation of Disease Severity Index for Predicting Complicated Disease in Crohn’s Disease: A comparison study with Lémann Index
P187 Validation of Disease Severity Index for Predicting Complicated Disease in Crohn’s Disease: A comparison study with Lémann Index Open
Background The recently developed Disease Severity Index (DSI) provides a comprehensive assessment of structural bowel damage (BD) in addition to short-term signs and symptoms. We aimed to evaluate DSI in identifying patients with Crohn’s …
View article: A Real-World Clinical Study of First-Time User of OC-01 (Varenicline Nasal Spray- Tyrvaya) For Dry Eye Disease-The Compliance and Acceptability
A Real-World Clinical Study of First-Time User of OC-01 (Varenicline Nasal Spray- Tyrvaya) For Dry Eye Disease-The Compliance and Acceptability Open
Purpose: To investigate the compliance and acceptance of first time using nasal spray OC-01 (Tyrvaya) for dry eye in order to study the potential strategy to improve the usage. Method: Twenty patients with DED either having resistance to e…
View article: Noggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration
Noggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration Open
A proper source of stem cells is key to muscle injury repair. Dental pulp stem cells (DPSCs) are an ideal source for the treatment of muscle injuries due to their high proliferative and differentiation capacities. However, the current myog…
View article: P1227 Revealing lower capacity of microbial metabolism of flavonoids and associated metabolic changes in Crohn’s disease
P1227 Revealing lower capacity of microbial metabolism of flavonoids and associated metabolic changes in Crohn’s disease Open
Background Recent studies highlight the role of interplay between oxidative stress, gut microbiota, and immune response in the etiology of Crohn’s disease (CD). Polyphenols are natural antioxidants which are mainly metabolized by gut micro…
View article: OP05 Primary efficacy and safety of mirikizumab in moderate to severe Crohn’s Disease: results of the treat-through VIVID 1 study
OP05 Primary efficacy and safety of mirikizumab in moderate to severe Crohn’s Disease: results of the treat-through VIVID 1 study Open
Background Mirikizumab (miri) is a selective IL23p19 monoclonal antibody approved for the treatment of ulcerative colitis. The primary focus of the VIVID-1 trial (NCT03926130) was to demonstrate the efficacy and safety of mirikizumab (miri…
View article: Two-stage method of free gingival graft prior to periodontal regenerative surgery for the treatment of intrabony defects with insufficient keratinised tissue width: a study protocol for an open-label randomised controlled trial
Two-stage method of free gingival graft prior to periodontal regenerative surgery for the treatment of intrabony defects with insufficient keratinised tissue width: a study protocol for an open-label randomised controlled trial Open
Introduction Guided tissue regeneration (GTR) combined with bone grafting for periodontal regenerative surgery has ideal clinical results for intrabony defect. However, some sites of intrabony defects often suffer from insufficient keratin…
View article: OP17 Upadacitinib Improves Endoscopic Outcomes in Patients with Moderate to Severely Active Crohn’s Disease Irrespective of Previous Failure to Respond to Biologics or Conventional Therapies
OP17 Upadacitinib Improves Endoscopic Outcomes in Patients with Moderate to Severely Active Crohn’s Disease Irrespective of Previous Failure to Respond to Biologics or Conventional Therapies Open
Background Upadacitinib (UPA), an oral, reversible JAK inhibitor, demonstrated superior efficacy compared to placebo (PBO) in patients with moderate to severe Crohn’s disease (CD) in 2 multicentre, phase 3 induction (U-EXCEL and U-EXCEED),…
View article: P056 Exposures linked with urban and rural living indicate that living in rural area but spending above 50% of daily-life in urban environment is linked with reduction in alpha-diversity, reduced rural index, and reduced microbial health index mirroring CD profile
P056 Exposures linked with urban and rural living indicate that living in rural area but spending above 50% of daily-life in urban environment is linked with reduction in alpha-diversity, reduced rural index, and reduced microbial health index mirroring CD profile Open
Background Efforts to delineate factors linked with rural to urban transition, paralleling the staggering rise in CD incidence, have been hampered by the universal modernization in the west. China is ongoing transition from a predominantly…
View article: BJN volume 126 issue 9 Cover and Back matter
BJN volume 126 issue 9 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: P467 Perception Gap between Patients with Inflammatory Bowel Disease (IBD) and Physicians in China: A Cross-sectional Study
P467 Perception Gap between Patients with Inflammatory Bowel Disease (IBD) and Physicians in China: A Cross-sectional Study Open
Background The aim of the study was to assess the perception of inflammatory bowel disease (IBD) among Chinese patients and physicians. Methods Data in this cross-sectional study was collected from 6/2020 to 8/2020, which covered 24 provin…
View article: P482 Selective prophylactic anti-tuberculosis strategy is superior for Chinese patients with inflammatory bowel disease receiving infliximab treatment: a multi-centre retrospective study
P482 Selective prophylactic anti-tuberculosis strategy is superior for Chinese patients with inflammatory bowel disease receiving infliximab treatment: a multi-centre retrospective study Open
During anti-TNF therapy, inflammatory bowel disease (IBD) patients either with or without latent tuberculosis infection (LTBI) active TB can develop. It remains unclear whether IBD patients without LTBI receiving prophylactic anti-TB has a…
View article: P486 Response to vedolizumab therapy in patients with inflammatory bowel disease: Impact of drug levels, anti-drug antibodies and α4β7 target occupancy
P486 Response to vedolizumab therapy in patients with inflammatory bowel disease: Impact of drug levels, anti-drug antibodies and α4β7 target occupancy Open
Real-life pharmacokinetics/pharmacodynamics data of vedolizumab are still scarce. Vedolizumab/AVA levels were measured in 106 prospectively followed inflammatory bowel disease (IBD) patients receiving vedolizumab induction and maintenance …